Results 101 to 110 of about 1,158,324 (307)

Dual Probe with Fluorescent and Magnetic Properties for Imaging Solid Tumor Xenografts

Molecular Imaging, 2007
A dual probe with fluorescent and magnetic reporter groups was constructed by linkage of the near-infrared (NIR) fluorescent transferrin conjugate (Tf NIR ) on the surface of contrast agent-encapsulated cationic liposome (Lip-CA). This probe was used for
Liang Shan, Songping Wang, Rajagopalan Sridhar, Zaver M. Bhujwalla, Paul C. Wang   +4 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Fluorescent nucleic acid probe in droplets for bacterial sorting (FNAP-sort) as a high-throughput screening method for environmental bacteria with various growth rates.

PLoS ONE, 2019
We have developed a new method for selectively sorting droplets containing growing bacteria using a fluorescence resonance energy transfer (FRET)-based RNA probe. Bacteria and the FRET-based RNA probe are encapsulated into nanoliter-scale droplets, which
Yuri Ota, Kanako Saito, Taeko Takagi, Satoko Matsukura, Masamune Morita, Satoshi Tsuneda, Naohiro Noda   +6 more
doaj   +1 more source

Highly sensitive and selective colorimetric and off-on fluorescent probe for Cu2+ based on rhodamine derivative

, 2010
A new probe for Cu2+ based on the Cu2+-induced reversible ring-opening mechanism of the rhodamine spirolactam was described. It displayed a highly selective and sensitive "turn-on" fluorescent and colorimetric response toward Cu2+.A new probe for Cu2 ...
Yu, Chunwei, Chen, Lingxin, Zhang, Jun, Wang, Rui   +3 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Synthesis of a fluorescent probe based on a heck coupling reaction for detecting Cu2 +

Next Materials
Copper ions, as heavy metal salt ions, are widely distributed in nature. Fluorescent probes with low detection limits have been increasingly used by researchers for the specific detection of copper ions; however, achieving highly responsive and easy-to ...
Xiujuan Gao, Guanchen Wang, Yueling Xu, Huijun Zeng, Chengju Sheng, Yichuan Zhang, Mingming Guo   +6 more
doaj   +1 more source

Fluorescent-Based Thermal Sensing in Lipid Membranes

, 2020
Thermal mapping in biological membranes could unlock and help us understand many chemical and physical processes that do not only pertain to localized membrane phenomena but also extend to many other intra- and extracellular pathways. In this manuscript,
Sarriah Hassoun (8363763), Sarriah Hassoun, Pierre Karam, Pierre Karam (1753474)   +3 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A novel small molecule fluorescent sensor for Zn2+ based on pyridine–pyridone scaffold [PDF]

, 2011
The development of a water-soluble and small molecular weight fluorescent probe, 3-(4-methoxyphenyl)-4-(methylsulfanyl)-6-(pyridin-2-yl)pyridin-2(1H)-one (3), for detecting Zn2+ based on pyridine-pyridone skeleton is reported.
Yamaguchi, Yasuchika, Yoshinori Tominaga, Yasuchika Yamaguchi, Hideo Saji, Mizuyama, Naoko, Masayori Hagimori, Hagimori, Masayori, Saji, Hideo, Tominaga, Yoshinori, Naoko Mizuyama   +9 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source