Results 101 to 110 of about 340,246 (317)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Time-resolved fluorescence-based europium-derived probes for peroxidase bioassays, citrate cycle imaging and chirality sensing

, 2005
The dissertation describes the development of europium-derived fluorescence probes for biological substances in aqueous solution. A scheme is shown in Fig. 7.1.
Lin, Zhihong
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Synthesis and Characterization of Sulfonamide-Containing Naphthalimides as Fluorescent Probes

Molecules
A tumor-targeting fluorescent probe has attracted increasing interest in fluorescent imaging for the noninvasive detection of cancers in recent years. Sulfonamide-containing naphthalimide derivatives (SN-2NI, SD-NI) were synthesized by the incorporation ...
Zhi-Wei Liu, Fan Liu, Chun-Tao Shao, Guo-Ping Yan, Jiang-Yu Wu   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Highly sensitive and selective colorimetric and off-on fluorescent probe for Cu2+ based on rhodamine derivative

, 2010
A new probe for Cu2+ based on the Cu2+-induced reversible ring-opening mechanism of the rhodamine spirolactam was described. It displayed a highly selective and sensitive "turn-on" fluorescent and colorimetric response toward Cu2+.A new probe for Cu2 ...
Yu, Chunwei, Chen, Lingxin, Zhang, Jun, Wang, Rui   +3 more
core  

Fluorescent-Based Thermal Sensing in Lipid Membranes

, 2020
Thermal mapping in biological membranes could unlock and help us understand many chemical and physical processes that do not only pertain to localized membrane phenomena but also extend to many other intra- and extracellular pathways. In this manuscript,
Sarriah Hassoun (8363763), Sarriah Hassoun, Pierre Karam, Pierre Karam (1753474)   +3 more
core   +1 more source

A novel small molecule fluorescent sensor for Zn2+ based on pyridine–pyridone scaffold [PDF]

, 2011
The development of a water-soluble and small molecular weight fluorescent probe, 3-(4-methoxyphenyl)-4-(methylsulfanyl)-6-(pyridin-2-yl)pyridin-2(1H)-one (3), for detecting Zn2+ based on pyridine-pyridone skeleton is reported.
Yamaguchi, Yasuchika, Yoshinori Tominaga, Yasuchika Yamaguchi, Hideo Saji, Mizuyama, Naoko, Masayori Hagimori, Hagimori, Masayori, Saji, Hideo, Tominaga, Yoshinori, Naoko Mizuyama   +9 more
core   +1 more source

Fluorescent probe for mercury ion imaging analysis: Strategies and applications

, 2021
Environmental pollution problem, especially mercury ions (Hg2+) pollution, seriously threatens the organism health. Numerous researches have revealed that even extremely low concentration of Hg2+ can severely damage the organisms.
Han, Xiaoyue, Wang, Yue, Zhang, Li, Chen, Lingxin, Zhang, Liangwei, Wang, Xiaoyan   +5 more
core   +1 more source