Results 111 to 120 of about 340,246 (317)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Cyanine-based colorimetric and fluorescent probe for the selective detection of diethylstilbestrol in seawater, shrimp and fish samples

, 2016
The synthetic estrogen drug diethylstilbestrol (DES) plays important roles in the treatment of estrogen deficiency disorders for human beings. The excessive intakes of DES can lead to physiological dysfunction and raise the risk of ovarian cancer, breast
Yin, K, Xie, ZH, Yu, FB, Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. lxchen@yic.ac.cn, Liu, DY, Chen, LX   +5 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Synthesis of a fluorescent probe based on a heck coupling reaction for detecting Cu2 +

Next Materials
Copper ions, as heavy metal salt ions, are widely distributed in nature. Fluorescent probes with low detection limits have been increasingly used by researchers for the specific detection of copper ions; however, achieving highly responsive and easy-to ...
Xiujuan Gao, Guanchen Wang, Yueling Xu, Huijun Zeng, Chengju Sheng, Yichuan Zhang, Mingming Guo   +6 more
doaj   +1 more source

Dual Probe with Fluorescent and Magnetic Properties for Imaging Solid Tumor Xenografts

Molecular Imaging, 2007
A dual probe with fluorescent and magnetic reporter groups was constructed by linkage of the near-infrared (NIR) fluorescent transferrin conjugate (Tf NIR ) on the surface of contrast agent-encapsulated cationic liposome (Lip-CA). This probe was used for
Liang Shan, Songping Wang, Rajagopalan Sridhar, Zaver M. Bhujwalla, Paul C. Wang   +4 more
doaj   +1 more source

Endogenous exosome labelling with an amphiphilic NIR-fluorescent probe

, 2018
The recognition of the biological, diagnostic and medical importance of exosomes has given rise to an urgent need for efficient labelling of these extracellular vesicles in ways that do not alter their inherent characteristics.
Bergese, Paolo, Raymond L. Stalings, John Nolan, Cheung, Shane, Donal F. O’Shea, Brendan Ffrench, Nolan, John, Zendrini, Andrea, O’Shea, Donal, Dan Wu, Wu, Dan, Monopoli, Marco, Gonzalo Sampedro, Durán Sampedro, Gonzalo, Paolo Bergese, Donal F. O'Shea, Marco P. Monopoli, Serena Ducoli, Andrea Zendrini, Stalings, Raymond, Olga Piskareva, Shane Cheung, French, Brendan, DUCOLI, SERENA, Piskareva, Olga   +24 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Fluorescent nucleic acid probe in droplets for bacterial sorting (FNAP-sort) as a high-throughput screening method for environmental bacteria with various growth rates.

PLoS ONE, 2019
We have developed a new method for selectively sorting droplets containing growing bacteria using a fluorescence resonance energy transfer (FRET)-based RNA probe. Bacteria and the FRET-based RNA probe are encapsulated into nanoliter-scale droplets, which
Yuri Ota, Kanako Saito, Taeko Takagi, Satoko Matsukura, Masamune Morita, Satoshi Tsuneda, Naohiro Noda   +6 more
doaj   +1 more source

Self-assembly of multi-component fluorescent molecular logic gates in micelles [PDF]

, 2016
A recent strategy for developing supramolecular logic gates in water is based on combinations of molecules via self-assembly with surfactants, which eliminates the need for time-consuming synthesis. The self-assembly of surfactants and lumophores and
Magri, David C., Costa, Paola F. da, Paterson, Kyle A.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source