Results 131 to 140 of about 1,158,324 (307)

A selective, turn-on fluorescent probe for live-cell super-resolution imaging of c-Src kinase [PDF]

Subcellular localization is important in regulating kinase activation and function. Small molecule flu-orescent probes for kinases can provide compli-mentary advantages to immunofluorescence and genetically encoded tags.
Taylor, Johnson, Matthew, Soellner, Kristoffer, Brandvold, Eric, Lachacz   +3 more
core   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Application of Fluorescent Probes for the Detection of Zinc Ions in Cells and Oil Paintings

Inorganics
Zinc is an essential trace metal element in the human body, but it also constitutes a variety of proteins in the body of the important elements necessary; this element plays an important role in physiological metabolism. Disturbances in the metabolism of
Zhankun Wang, Zhixin Ren, Yanan Niu, Xi Cao, Yuguang Lv   +4 more
doaj   +1 more source

A water-soluble and fast-response mitochondria-targeted fluorescent probe for colorimetric and ratiometric sensing of endogenously generated SO2 derivatives in living cells

, 2016
A novel water-soluble mitochondria-targeted ratiometric fluorescent probe (Cl-2) is presented. Cl-2 can respond selectively to SO2 derivatives within 1 min.
Liu, Y, Wang, X, Xie, KX, Yu, KK, Li, K, Yu, XQ (reprint author), Sichuan Univ, Minist Educ, Coll Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China., Li, LL, Yu, XQ   +7 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Fluorescent probe for copper(II) ion based on a rhodamine spirolactame derivative, and its application to fluorescent imaging in living cells

, 2011
A fluorescent probe for Cu(II) ion is presented. It is based on the rhodamine fluorophore and exhibits high selectivity and sensitivity for Cu(II) ion in aqueous methanol (2:8, v/v) at pH 7.0.
Yu, Chunwei, Wei, Peihai, Chen, Lingxin, Li, Jinhua, Liu, Ping, Zhang, Jun   +5 more
core  

Fluorescent-Cavity Host: An Efficient Probe to Study Supramolecular Recognition Mechanisms

, 2018
Using fluorometry to study the interactions between guests and host cavities is often challenging, especially for hosts with small cavities because the fluorophore may not be close to the binding site. Therefore, it is critical to overcome this hurdle to
Linxian Xu (4856353), Herbert Meier (2032801), Derong Cao (1435111), Lingyun Wang (1317075), Guozhen Zhang (1708621), Hao Tang (44155), Wei Cui (92129)   +6 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A turn on fluorescent probe for Zn2+ based on Quinoline with flexible chelating group

Results in Chemistry
In this work, a Zn2+ fluorescent probe based on quinoline was designed and synthesized. The flexible diethanolamine was attached to 8-Hydroxyquinoline-2-carboxaldehyde, forming a well-dissolved and biocompatible fluorescent probe. As a recognition group,
Dacheng Zheng, Rui Huang, Haichuang Lan
doaj   +1 more source