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A radiosynthesis of fluorine-18 fluoromisonidazole.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1989A new preparation of [18F]fluoromisonidazole [1H-1-(3-[18F] fluoro-2-hydroxypropyl)-2-nitroimidazole] is presented as a two-step, two-pot reaction sequence. The method is useful for the production of 20-30 mCi quantities of this compound from [18F]fluoride, available in 40% radiochemical yield at end of bombardment (EOB) with a specific activity (nca ...
J R, Grierson +4 more
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Fluorine-18-Labelled Fluoropyridines: Advances in Radiopharmaceutical Design
Current Pharmaceutical Design, 2005Positron Emission Tomography is a high-resolution, sensitive, functional imaging technique, which can efficiently give access to the distribution, pharmacokinetics and -dynamics of a drug in vivo and which can therefore advantageously play a key-role in both drug discovery and development.
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Recent progress in fluorine-18 labelled peptide radiopharmaceuticals
European Journal of Nuclear Medicine, 2001The application of biologically active peptides labelled with positron-emitting nuclides has emerged as a useful and interesting field in nuclear medicine. Small synthetic receptor-binding peptides are currently the preferred agents over proteins and antibodies for diagnostic imaging of various tumours.
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The International Journal of Applied Radiation and Isotopes, 1975
R.W. Goulding, S.W. Gunasekera
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R.W. Goulding, S.W. Gunasekera
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Fluorine-18 labeled receptor based radiopharmaceuticals
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1986M R, Kilbourn, M J, Welch
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Bioorthogonal Reaction for Fluorine-18 Labeling
2018Specific molecular imaging probes including radiopharmaceuticals labeled with positron-emitters, such as fluorine-18 (18F, t1/2 = 109.8 min), need to expand their applications of positron emission tomography (PET) molecular imaging study. In recent years, bioorthogonal chemistry such as inverse electron-demand Diels-Alder cycloaddition reactions and ...
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Fluorine-18 chemistry in micro-reactors.
Journal of labelled compounds & radiopharmaceuticalsRecent applications of micro-reactor (microfluidics) technology to radiofluorination chemistry within our laboratory are presented, based on use of either a simple T-shaped glass micro-reactor or a more advanced microfluidics instrument.
Shuiyu, Lu +2 more
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Preparation of fluorine-18-labeled haloperidol
Journal of Medicinal Chemistry, 1975C. S. Kook, M. F. Reed, G. A. Digenis
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