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Recommendations for fluorine-18 production [PDF]
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1991 Abstract Data for the production of fluorine-18 (t 1/2 = 109.6 min; β + = 100%) are reviewed. The experience of some well-established European centres for positron emission tomography (PET), in the routine production of fluorine-18 for the purpose of labelling radiopharmaceuticals, is described.
Guillaume, Marcel +5 more
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Therapy Monitoring with Fluorine-18 FDG-PET and Fluorine-18 FDG-PET/CT
PET Clinics, 2008PET with the glucose analog [18F]-FDG is increasingly used to monitor tumor response in patients undergoing chemotherapy and chemoradiotherapy. The clinical value of FDG PET for differentiation of residual tumor and therapy-induced fibrosis has been documented for gastrointestinal cancer.
Hinrich A, Wieder, Ken, Herrmann
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Metabolism of Fluorine 18 in Domestic Animals
American Journal of Physiology-Legacy Content, 1955Amounts of F/sup 18/ sufficient to permit studies up to 10 hours duration in domestic animals with non-toxic levels of total fluorine have become available from cyclotron production. The initial rate of disappearance of intravenously injected F/sup 18/ from the blood was found to be 41 and 32% of the dose/min.
J D, PERKINSON +4 more
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Journal of Nuclear Science and Technology, 1964
Fluorine-18 was prepared by neutron irradiation of lithium carbonate in the reactor JRR-1. Five grams of lithium carbonate was irradiated for 2hr with a thermal neutron flux of 6×1011 n/cm2/sec. An alumina column was used to separate 18F from the irradiated material.
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Fluorine-18 was prepared by neutron irradiation of lithium carbonate in the reactor JRR-1. Five grams of lithium carbonate was irradiated for 2hr with a thermal neutron flux of 6×1011 n/cm2/sec. An alumina column was used to separate 18F from the irradiated material.
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Preparation of carrier-free fluorine-18
The International Journal of Applied Radiation and Isotopes, 1977Abstract A method for the preparation of carrier-free fluorine-18 using a column of hydrous stannic oxide is described. The adsorption and desorption characteristics of the fluoride ion on the column has been investigated using F-18 as a tracer. The present study has confirmed that the fluoride ion is practically completely adsorbed on the column in ...
T H, Hsieh +3 more
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A cyclotron method for the production of fluorine-18
The International Journal of Applied Radiation and Isotopes, 1966Abstract Fluorine-18 is produced, with yields of up to 40 mc/hr, by the bombardment of water contained in a suitable target held in the external α-particle beam of a 30 MeV cyclotron: a method is described which is in routine use to produce samples for medical research purposes.
J C, Clark, D J, Silvester
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Journal of Inorganic and Nuclear Chemistry, 1964
Radiochemically pure 18F has been prepared by three different methods and its decay has been followed with β proportional counters and γ-ray counters in an effort to measure the half-life accurately. Analysis by a computer program that used the method of least squares gave a weighted mean half-life of 18F and a weighted standard deviation of the mean ...
J.D. Mahony, S.S. Markowitz
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Radiochemically pure 18F has been prepared by three different methods and its decay has been followed with β proportional counters and γ-ray counters in an effort to measure the half-life accurately. Analysis by a computer program that used the method of least squares gave a weighted mean half-life of 18F and a weighted standard deviation of the mean ...
J.D. Mahony, S.S. Markowitz
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Fluorine-18 Labeling of Peptides and Proteins
2006The pool of promising peptides worthy of investigation and evaluation for clinical use is continuously filled from different sources. Driven by the promising results obtained with peptides addressing somatostatin-2 receptor positive (sst2+) neuroendocrine tumours, other peptides targeting further receptor systems are being studied and evaluated ...
H J, Wester, M, Schottelius
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European Journal of Nuclear Medicine, 2000
Fluorine-18 labelled alpha-methyltyrosine (FMT) was developed for positron emission tomography (PET) imaging, and its potential for clinical application in patients with brain tumours has been demonstrated. This is the first trial to compare FMT with 18F-fluoro-2-deoxy-D-glucose (FDG) for the evaluation of musculoskeletal tumours. Seventy-five patients
H, Watanabe +10 more
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Fluorine-18 labelled alpha-methyltyrosine (FMT) was developed for positron emission tomography (PET) imaging, and its potential for clinical application in patients with brain tumours has been demonstrated. This is the first trial to compare FMT with 18F-fluoro-2-deoxy-D-glucose (FDG) for the evaluation of musculoskeletal tumours. Seventy-five patients
H, Watanabe +10 more
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Fluorine-18 Fluorodeoxyglucose Uptake in the Retractile Testis
Clinical Nuclear Medicine, 1999A 51-year-old man with a palpable mass in his right inguinal region had fluorine-18 fluorodeoxyglucose (F-18 FDG) whole-body positron emission tomography (PET) in our cancer screening program. FDG accumulated in the mass, suggesting a metabolically active lesion that was likely malignant.
H, Fujii +5 more
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