Results 1 to 10 of about 118 (84)

Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes

Molecules, 2013
The polymer supported phosphazene bases PS-P2tBu and the novel PS-P2PEG allowed for efficient extraction of [18F]F− from proton irradiated [18O]H2O and subsequent radiofluorination of a broad range of substrates directly on the resin.
Fedor Zhuravlev
exaly   +3 more sources

Lewis Acid-Facilitated Radiofluorination of MN3PU: A LRRK2 Radiotracer

Molecules, 2020
Background: Temperature-sensitive radiopharmaceutical precursors require lower reaction temperatures (
Ralf Schirrmacher, Paul Schaffer, Schirrmacher Ralf   +2 more
exaly   +3 more sources

Radiosynthesis of 5-[¹⁸F]Fluoro-1,2,3-triazoles through Aqueous Iodine–[¹⁸F]Fluorine Exchange Reaction

Molecules, 2021
In this report, a simple and efficient process to achieve fluorine-18-labeled 1,2,3-triazole is reported. The heteroaromatic radiofluorination was successfully achieved through an iodine–fluorine-18 exchange in an aqueous medium requiring only trace ...
Xiang Zhang, Falguni Basuli, Sameh Abdelwahed, Tadhg Begley, Rolf Swenson   +4 more
doaj   +1 more source

[18F]Tosyl fluoride as a versatile [18F]fluoride source for the preparation of 18F-labeled radiopharmaceuticals

Scientific Reports, 2023
Positron emission tomography (PET) is an in vivo imaging technology that utilizes positron-emitting radioisotope-labeled compounds as PET radiotracers that are commonly used in clinic and in various research areas, including oncology, cardiology, and ...
Dong Zhou, Wenhua Chu, Jinbin Xu, Sally Schwarz, John A. Katzenellenbogen   +4 more
doaj   +1 more source

Mild, Organo-Catalysed Borono-Deamination as a Key to Late-Stage Pharmaceutical Precursors and 18F-Labelled Radiotracers

Frontiers in Chemistry, 2022
A tris(pentafluorophenyl)borane catalysed method for the synthesis of boronic acid esters from aromatic amines in yields of up to 93% was devised.
Raúl M. Pérez-García, Patrick J. Riss, Patrick J. Riss, Patrick J. Riss, Patrick J. Riss   +4 more
doaj   +1 more source

Effective Preparation of [¹⁸F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor

Molecules, 2022
(1) Background: [18F]Flumazenil 1 ([18F]FMZ) is an established positron emission tomography (PET) radiotracer for the imaging of the gamma-aminobutyric acid (GABA) receptor subtype, GABAA in the brain.
Mohammad B. Haskali, Peter D. Roselt, Terence J. O’Brien, Craig A. Hutton, Idrish Ali, Lucy Vivash, Bianca Jupp   +6 more
doaj   +1 more source

One-Pot Radiosynthesis of [¹⁸F]Anle138b—5-(3-Bromophenyl)-3-(6-[¹⁸F]fluorobenzo[d][1,3]dioxol-5-yl)-1H-pyrazole—A Potential PET Radiotracer Targeting α-Synuclein Aggregates

Molecules, 2023
Availability of PET imaging radiotracers targeting α-synuclein aggregates is important for early diagnosis of Parkinson’s disease and related α-synucleinopathies, as well as for the development of new therapeutics.
Viktoriya V. Orlovskaya, Olga S. Fedorova, Nikolai B. Viktorov, Daria D. Vaulina, Raisa N. Krasikova   +4 more
doaj   +1 more source

Efforts toward PET-Activatable Red-Shifted Silicon Rhodamines and Silicon Pyronine Dyes

Pharmaceuticals, 2023
Tracers for bimodal optical imaging and positron emission tomography unite multiple advantages in a single molecule. Their tumor-specific uptake can be visualized after their PET activation by radiofluorination via PET/CT or PET/MRI allowing for staging ...
Carsten Sven Kramer, Thines Kanagasundaram, Jessica Matthias, Klaus Kopka   +3 more
doaj   +1 more source

Automated Optimized Synthesis of [¹⁸F]FLT Using Non-Basic Phase-Transfer Catalyst with Reduced Precursor Amount

Molecules, 2022
3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) is a positron emission tomography (PET) tracer useful for tumor proliferation assessment for a number of cancers, particularly in the cases of brain, lung, and breast tumors.
Olga S. Fedorova, Viktoriya V. Orlovskaya, Raisa N. Krasikova   +2 more
doaj   +1 more source

MODIFICATION OF [18F]FDG BY THE FORMATION OF A HYDRAZONE BOND [PDF]

Journal of IMAB, 2023
Purpose: The [18F]-fluorodeoxyglucose ([18F]-FDG) is known to be one of the most used radio-pharmaceuticals for positron emission tomography. [18F]-FDG allows the assessment of glycolytic activity, which is more enhanced in tumor cells than in normal ...
Gergana Simeonova, Boyan Todorov
doaj   +1 more source