Results 21 to 30 of about 1,195 (160)

Efforts toward PET-Activatable Red-Shifted Silicon Rhodamines and Silicon Pyronine Dyes

Pharmaceuticals, 2023
Tracers for bimodal optical imaging and positron emission tomography unite multiple advantages in a single molecule. Their tumor-specific uptake can be visualized after their PET activation by radiofluorination via PET/CT or PET/MRI allowing for staging ...
Carsten Sven Kramer, Thines Kanagasundaram, Jessica Matthias, Klaus Kopka   +3 more
doaj   +1 more source

Automated Optimized Synthesis of [¹⁸F]FLT Using Non-Basic Phase-Transfer Catalyst with Reduced Precursor Amount

Molecules, 2022
3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) is a positron emission tomography (PET) tracer useful for tumor proliferation assessment for a number of cancers, particularly in the cases of brain, lung, and breast tumors.
Olga S. Fedorova, Viktoriya V. Orlovskaya, Raisa N. Krasikova   +2 more
doaj   +1 more source

Peptides Radiofluorination: Main Methods and Highlights

International Journal of Organic Chemistry, 2022
Marcelo Mamede
exaly   +2 more sources

Effective Preparation of [¹⁸F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor

Molecules, 2022
(1) Background: [18F]Flumazenil 1 ([18F]FMZ) is an established positron emission tomography (PET) radiotracer for the imaging of the gamma-aminobutyric acid (GABA) receptor subtype, GABAA in the brain.
Mohammad B. Haskali, Peter D. Roselt, Terence J. O’Brien, Craig A. Hutton, Idrish Ali, Lucy Vivash, Bianca Jupp   +6 more
doaj   +1 more source

One-Pot Radiosynthesis of [¹⁸F]Anle138b—5-(3-Bromophenyl)-3-(6-[¹⁸F]fluorobenzo[d][1,3]dioxol-5-yl)-1H-pyrazole—A Potential PET Radiotracer Targeting α-Synuclein Aggregates

Molecules, 2023
Availability of PET imaging radiotracers targeting α-synuclein aggregates is important for early diagnosis of Parkinson’s disease and related α-synucleinopathies, as well as for the development of new therapeutics.
Viktoriya V. Orlovskaya, Olga S. Fedorova, Nikolai B. Viktorov, Daria D. Vaulina, Raisa N. Krasikova   +4 more
doaj   +1 more source

MODIFICATION OF [18F]FDG BY THE FORMATION OF A HYDRAZONE BOND [PDF]

Journal of IMAB, 2023
Purpose: The [18F]-fluorodeoxyglucose ([18F]-FDG) is known to be one of the most used radio-pharmaceuticals for positron emission tomography. [18F]-FDG allows the assessment of glycolytic activity, which is more enhanced in tumor cells than in normal ...
Gergana Simeonova, Boyan Todorov
doaj   +1 more source

Strained Ammonium Precursors for Radiofluorinations

ChemistryOpen, 2022
AbstractThe increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of novel and versatile techniques to introduce fluorine‐18, especially for the radiolabelling of biologically or pharmacologically active molecules.
Reissig, F., Mamat, C.
openaire   +4 more sources

Reaction of [18F]Fluoride at Heteroatoms and Metals for Imaging of Peptides and Proteins by Positron Emission Tomography

Frontiers in Chemistry, 2021
The ability to radiolabel proteins with [18F]fluoride enables the use of positron emission tomography (PET) for the early detection, staging and diagnosis of disease.
Kymberley R. Scroggie, Michael V. Perkins, Justin M. Chalker   +2 more
doaj   +1 more source

Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging

Molecules, 2020
Recent progress realized in the development of optical imaging (OPI) probes and devices has made this technique more and more affordable for imaging studies and fluorescence-guided surgery procedures.
Maxime Munch, Benjamin H. Rotstein, Gilles Ulrich   +2 more
doaj   +1 more source

Novel Radioiodinated and Radiofluorinated Analogues of FT-2102 for SPECT or PET Imaging of mIDH1 Mutant Tumours

Molecules, 2022
Isocitrate dehydrogenases (IDHs) are metabolic enzymes commonly mutated in human cancers (glioma, acute myeloid leukaemia, chondrosarcoma, and intrahepatic cholangiocarcinoma).
Valérie Weber, Lucie Arnaud, Sladjana Dukic-Stefanovic, Barbara Wenzel, Valérie Roux, Jean-Michel Chezal, Thu-Hang Lai, Rodrigo Teodoro, Klaus Kopka, Elisabeth Miot-Noirault, Winnie Deuther-Conrad, Aurélie Maisonial-Besset   +11 more
doaj   +1 more source