Results 21 to 30 of about 2,508 (203)

Effective Preparation of [¹⁸F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor

Molecules, 2022
(1) Background: [18F]Flumazenil 1 ([18F]FMZ) is an established positron emission tomography (PET) radiotracer for the imaging of the gamma-aminobutyric acid (GABA) receptor subtype, GABAA in the brain.
Mohammad B. Haskali, Peter D. Roselt, Terence J. O’Brien, Craig A. Hutton, Idrish Ali, Lucy Vivash, Bianca Jupp   +6 more
doaj   +1 more source

One-Pot Radiosynthesis of [¹⁸F]Anle138b—5-(3-Bromophenyl)-3-(6-[¹⁸F]fluorobenzo[d][1,3]dioxol-5-yl)-1H-pyrazole—A Potential PET Radiotracer Targeting α-Synuclein Aggregates

Molecules, 2023
Availability of PET imaging radiotracers targeting α-synuclein aggregates is important for early diagnosis of Parkinson’s disease and related α-synucleinopathies, as well as for the development of new therapeutics.
Viktoriya V. Orlovskaya, Olga S. Fedorova, Nikolai B. Viktorov, Daria D. Vaulina, Raisa N. Krasikova   +4 more
doaj   +1 more source

¹⁸F-Radiopharmaceutical Diversification Enabled by Deaminative Cross-Electrophile Couplings. [PDF]

Angew Chem Int Ed Engl
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Ogilvy IF, Ford J, Ortalli S, Renders E, Hayes TR, Liu S, Mortiers I, Nikolopoulou A, Sorlin AM, Trabanco AA, Tredwell M, Buijnsters PJJA, Salter R, Gouverneur V.   +13 more
europepmc   +2 more sources

Radiofluorination using aluminum-fluoride (Al18F) [PDF]

EJNMMI Research, 2013
Targeted agents are increasingly used for treating cancer and other diseases, but patients may need to be carefully selected to maximize the potential for therapeutic benefit. One way to select patients is to bind an imaging radionuclide to a targeting agent of interest, so that its uptake in specific sites of disease can be visualized by positron ...
McBride, William J, Sharkey, Robert M, Goldenberg, David M   +2 more
openaire   +2 more sources

Efforts toward PET-Activatable Red-Shifted Silicon Rhodamines and Silicon Pyronine Dyes

Pharmaceuticals, 2023
Tracers for bimodal optical imaging and positron emission tomography unite multiple advantages in a single molecule. Their tumor-specific uptake can be visualized after their PET activation by radiofluorination via PET/CT or PET/MRI allowing for staging ...
Carsten Sven Kramer, Thines Kanagasundaram, Jessica Matthias, Klaus Kopka   +3 more
doaj   +1 more source

Automated Optimized Synthesis of [¹⁸F]FLT Using Non-Basic Phase-Transfer Catalyst with Reduced Precursor Amount

Molecules, 2022
3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) is a positron emission tomography (PET) tracer useful for tumor proliferation assessment for a number of cancers, particularly in the cases of brain, lung, and breast tumors.
Olga S. Fedorova, Viktoriya V. Orlovskaya, Raisa N. Krasikova   +2 more
doaj   +1 more source

MODIFICATION OF [18F]FDG BY THE FORMATION OF A HYDRAZONE BOND [PDF]

Journal of IMAB, 2023
Purpose: The [18F]-fluorodeoxyglucose ([18F]-FDG) is known to be one of the most used radio-pharmaceuticals for positron emission tomography. [18F]-FDG allows the assessment of glycolytic activity, which is more enhanced in tumor cells than in normal ...
Gergana Simeonova, Boyan Todorov
doaj   +1 more source

Sultones for Radiofluorination and Bioconjugation: Fluorine-18 Labeling of Native Proteins and Glycoproteins [PDF]

ACS Omega
Anne-Elodie Lafargue, Clémence Maingueneau, Benoit Bernay, Abdelaziz Ejjoummany, Cécile Perrio   +4 more
doaj   +2 more sources

Arene Radiofluorination Enabled by Photoredox-Mediated Halide Interconversion [PDF]

Nature Chemistry, 2020
Abstract Positron emission tomography (PET) is a powerful imaging technology that could visualize and measure metabolic processes in vivo and/or obtain unique information about drug candidates at early stages. Identification of new and improved molecular probes plays a critical role in PET, but its progress is limited in many situations due to ...
Wei Chen, Hui Wang, Nicholas E. S. Tay, Vincent A. Pistritto, Kang-Po Li, Tao Zhang, Zhanhong Wu, David A. Nicewicz, Zibo Li   +8 more
openaire   +3 more sources

Reaction of [18F]Fluoride at Heteroatoms and Metals for Imaging of Peptides and Proteins by Positron Emission Tomography

Frontiers in Chemistry, 2021
The ability to radiolabel proteins with [18F]fluoride enables the use of positron emission tomography (PET) for the early detection, staging and diagnosis of disease.
Kymberley R. Scroggie, Michael V. Perkins, Justin M. Chalker   +2 more
doaj   +1 more source