Results 31 to 40 of about 1,169 (122)

Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging

Molecules, 2020
Recent progress realized in the development of optical imaging (OPI) probes and devices has made this technique more and more affordable for imaging studies and fluorescence-guided surgery procedures.
Maxime Munch, Benjamin H. Rotstein, Gilles Ulrich   +2 more
doaj   +1 more source

Novel Radioiodinated and Radiofluorinated Analogues of FT-2102 for SPECT or PET Imaging of mIDH1 Mutant Tumours

Molecules, 2022
Isocitrate dehydrogenases (IDHs) are metabolic enzymes commonly mutated in human cancers (glioma, acute myeloid leukaemia, chondrosarcoma, and intrahepatic cholangiocarcinoma).
Valérie Weber, Lucie Arnaud, Sladjana Dukic-Stefanovic, Barbara Wenzel, Valérie Roux, Jean-Michel Chezal, Thu-Hang Lai, Rodrigo Teodoro, Klaus Kopka, Elisabeth Miot-Noirault, Winnie Deuther-Conrad, Aurélie Maisonial-Besset   +11 more
doaj   +1 more source

Recent Advances in Synthetic Methodologies to Form C-18F Bonds

Frontiers in Chemistry, 2022
Positron emission tomography (PET) is an important technique for the early diagnosis of disease. Due to the specific physical and chemical properties of Fluorine-18, this important isotope is widely used in PET for labelling and molecular imaging, and ...
Zhiyi Liu, Zhiyi Liu, Yijun Sun, Yijun Sun, Tianfei Liu, Tianfei Liu, Tianfei Liu   +6 more
doaj   +1 more source

Triflyl [¹⁸F]Fluoride as a Solution for Base-Sensitive Late-Stage Nucleophilic Aromatic ¹⁸F-Fluorination Reactions. [PDF]

Chemistry
Here, we present the late‐stage nucleophilic 18F‐fluorination of (hetero)aryls under low‐base conditions using triflyl [18F]fluoride. This method avoids the application of base and cryptand and enabled the efficient radiolabeling of a broad scope of (hetero)arenes and the successful production of clinical doses of [18F]mFBG, [18F]SynVesT‐1 and [18F ...
Haveman LYF, de Kruijff AMT, van Eeden SPP, Windhorst AD, Vugts DJ.   +4 more
europepmc   +2 more sources

Recent Advances in ¹⁸F-Labeled Amino Acids Synthesis and Application

Pharmaceutics, 2022
Radiolabeled amino acids are an important class of agents for positron emission tomography imaging that target amino acid transporters in many tumor types.
Chao Wang, Rong Lin, Shaobo Yao
doaj   +1 more source

A Convenient Route to New (Radio)Fluorinated and (Radio)Iodinated Cyclic Tyrosine Analogs

Pharmaceuticals, 2022
The use of radiolabeled non-natural amino acids can provide high contrast SPECT/PET metabolic imaging of solid tumors. Among them, radiohalogenated tyrosine analogs (i.e., [123I]IMT, [18F]FET, [18F]FDOPA, [123I]8-iodo-L-TIC(OH), etc.) are of particular ...
Maria Noelia Chao, Jean-Michel Chezal, Eric Debiton, Damien Canitrot, Tiffany Witkowski, Sophie Levesque, Françoise Degoul, Sébastien Tarrit, Barbara Wenzel, Elisabeth Miot-Noirault, Audrey Serre, Aurélie Maisonial-Besset   +11 more
doaj   +1 more source

Production of 6-l-[¹⁸F]Fluoro-m-tyrosine in an Automated Synthesis Module for ¹¹C-Labeling

Molecules, 2021
6-l-[18F]Fluoro-m-tyrosine (6-l-[18F]FMT) represents a valuable alternative to 6-l-[18F]FDOPA which is conventionally used for the diagnosis and staging of Parkinson’s disease.
Viktoriya V. Orlovskaya, Austin S. Craig, Olga S. Fedorova, Olga F. Kuznetsova, Bernd Neumaier, Raisa N. Krasikova, Boris D. Zlatopolskiy   +6 more
doaj   +1 more source

Development of Customized [18F]Fluoride Elution Techniques for the Enhancement of Copper-Mediated Late-Stage Radiofluorination

Scientific Reports, 2017
In a relatively short period of time, transition metal-mediated radiofluorination reactions have changed the PET radiochemistry landscape. These reactions have enabled the radiofluorination of a wide range of substrates, facilitating access to ...
Andrew V. Mossine, Allen F. Brooks, Naoko Ichiishi, Katarina J. Makaravage, Melanie S. Sanford, Peter J. H. Scott   +5 more
doaj   +1 more source

A Practical Method for the Preparation of 18F-Labeled Aromatic Amino Acids from Nucleophilic [18F]Fluoride and Stannyl Precursors for Electrophilic Radiohalogenation

Molecules, 2017
In a recent contribution of Scott et al., the substrate scope of Cu-mediated nucleophilic radiofluorination with [18F]KF for the preparation of 18F-labeled arenes was extended to aryl- and vinylstannanes.
Fadi Zarrad, Boris D. Zlatopolskiy, Philipp Krapf, Johannes Zischler, Bernd Neumaier   +4 more
doaj   +1 more source

Sultones for Radiofluorination and Bioconjugation: Fluorine-18 Labeling of Native Proteins and Glycoproteins [PDF]

ACS Omega
Anne-Elodie Lafargue, Clémence Maingueneau, Benoit Bernay, Abdelaziz Ejjoummany, Cécile Perrio   +4 more
doaj   +2 more sources