Results 31 to 40 of about 1,195 (160)

Recent Advances in Synthetic Methodologies to Form C-18F Bonds

Frontiers in Chemistry, 2022
Positron emission tomography (PET) is an important technique for the early diagnosis of disease. Due to the specific physical and chemical properties of Fluorine-18, this important isotope is widely used in PET for labelling and molecular imaging, and ...
Zhiyi Liu, Zhiyi Liu, Yijun Sun, Yijun Sun, Tianfei Liu, Tianfei Liu, Tianfei Liu   +6 more
doaj   +1 more source

Sultones for Radiofluorination and Bioconjugation: Fluorine-18 Labeling of Native Proteins and Glycoproteins [PDF]

ACS Omega
Anne-Elodie Lafargue, Clémence Maingueneau, Benoit Bernay, Abdelaziz Ejjoummany, Cécile Perrio   +4 more
doaj   +2 more sources

Recent Advances in ¹⁸F-Labeled Amino Acids Synthesis and Application

Pharmaceutics, 2022
Radiolabeled amino acids are an important class of agents for positron emission tomography imaging that target amino acid transporters in many tumor types.
Chao Wang, Rong Lin, Shaobo Yao
doaj   +1 more source

A Convenient Route to New (Radio)Fluorinated and (Radio)Iodinated Cyclic Tyrosine Analogs

Pharmaceuticals, 2022
The use of radiolabeled non-natural amino acids can provide high contrast SPECT/PET metabolic imaging of solid tumors. Among them, radiohalogenated tyrosine analogs (i.e., [123I]IMT, [18F]FET, [18F]FDOPA, [123I]8-iodo-L-TIC(OH), etc.) are of particular ...
Maria Noelia Chao, Jean-Michel Chezal, Eric Debiton, Damien Canitrot, Tiffany Witkowski, Sophie Levesque, Françoise Degoul, Sébastien Tarrit, Barbara Wenzel, Elisabeth Miot-Noirault, Audrey Serre, Aurélie Maisonial-Besset   +11 more
doaj   +1 more source

Production of 6-l-[¹⁸F]Fluoro-m-tyrosine in an Automated Synthesis Module for ¹¹C-Labeling

Molecules, 2021
6-l-[18F]Fluoro-m-tyrosine (6-l-[18F]FMT) represents a valuable alternative to 6-l-[18F]FDOPA which is conventionally used for the diagnosis and staging of Parkinson’s disease.
Viktoriya V. Orlovskaya, Austin S. Craig, Olga S. Fedorova, Olga F. Kuznetsova, Bernd Neumaier, Raisa N. Krasikova, Boris D. Zlatopolskiy   +6 more
doaj   +1 more source

Development of Customized [18F]Fluoride Elution Techniques for the Enhancement of Copper-Mediated Late-Stage Radiofluorination

Scientific Reports, 2017
In a relatively short period of time, transition metal-mediated radiofluorination reactions have changed the PET radiochemistry landscape. These reactions have enabled the radiofluorination of a wide range of substrates, facilitating access to ...
Andrew V. Mossine, Allen F. Brooks, Naoko Ichiishi, Katarina J. Makaravage, Melanie S. Sanford, Peter J. H. Scott   +5 more
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A Practical Method for the Preparation of 18F-Labeled Aromatic Amino Acids from Nucleophilic [18F]Fluoride and Stannyl Precursors for Electrophilic Radiohalogenation

Molecules, 2017
In a recent contribution of Scott et al., the substrate scope of Cu-mediated nucleophilic radiofluorination with [18F]KF for the preparation of 18F-labeled arenes was extended to aryl- and vinylstannanes.
Fadi Zarrad, Boris D. Zlatopolskiy, Philipp Krapf, Johannes Zischler, Bernd Neumaier   +4 more
doaj   +1 more source

Al¹⁸F: A New Standard for Radiofluorination [PDF]

Journal of Nuclear Medicine, 2013
TO THE EDITOR: 18F is the most common radionuclide used in PET imaging, but its application via a rapid, simple, easily accessible labeling procedure has been challenging. We congratulate Wan et al.
Goldenberg, D.M., Sharkey, R.M., McBride, W.J., Boerman, O.C.   +3 more
openaire   +3 more sources

Synthesis of a Potent Aminopyridine-Based nNOS-Inhibitor by Two Recent No-Carrier-Added 18F-Labelling Methods

Molecules, 2016
Nitric oxide (NO), an important multifunctional signaling molecule, is produced by three isoforms of NO-synthase (NOS) and has been associated with neurodegenerative disorders.
Christian Drerup, Johannes Ermert, Heinz H. Coenen   +2 more
doaj   +1 more source

Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) ¹⁸F-Radiopharmaceuticals

Pharmaceuticals, 2021
The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of 18F-radiopharmaceuticals for medical imaging.
Lexi Gower-Fry, Travis Kronemann, Andreas Dorian, Yinglan Pu, Carolin Jaworski, Carmen Wängler, Peter Bartenstein, Leonie Beyer, Simon Lindner, Klaus Jurkschat, Björn Wängler, Justin J. Bailey, Ralf Schirrmacher   +12 more
doaj   +1 more source