Results 51 to 60 of about 2,508 (203)
Molecules, 2017 In a recent contribution of Scott et al., the substrate scope of Cu-mediated nucleophilic radiofluorination with [18F]KF for the preparation of 18F-labeled arenes was extended to aryl- and vinylstannanes.
Fadi Zarrad +4 more
doaj +1 more source
Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent
EJNMMI Research, 2022 Purpose Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer.
Claudia Rose Fraser +11 more
doaj +1 more source
Isotopic Radiolabeling of the Antiretroviral Drug [18F]Dolutegravir for Pharmacokinetic PET Imaging
Pharmaceuticals, 2022 Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegravir (DTG) is one
Marion Tisseraud +9 more
doaj +1 more source
Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation [PDF]
, 2013 New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated.
Carlin, Stephen M. +7 more
core +6 more sources
Nanomaterials, 2023 This study describes the synthesis, radiofluorination and purification of an anionic amphiphilic teroligomer developed as a stabilizer for siRNA-loaded calcium phosphate nanoparticles (CaP-NPs).
Barbara Wenzel +10 more
doaj +1 more source
New Lyophilized Kit for Rapid Radiofluorination of Peptides [PDF]
Bioconjugate Chemistry, 2012 Radiolabeling compounds with positron-emitting radionuclides often involves a time-consuming, customized process. Herein, we report a simple lyophilized kit formulation for labeling peptides with (18)F, based on the aluminum-fluoride procedure. The prototype kit contains IMP485, a NODA (1,4,7-triazacyclononane-1,4-diacetate)-MPAA (methyl phenylacetic ...
William J, McBride +4 more
openaire +2 more sources
Synthesis of 2′‐[F‐18]fluoro‐2′‐DEOXY‐β‐D‐arabinofuranosyl nucleosides [PDF]
, 2001 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91186/1/25804401320_ftp ...
Anderson, L. +3 more
core +1 more source
Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase [PDF]
, 2016 We thank EPSRC and the Scottish Imaging Network (SINAPSE) for grants. DO’H thanks the Royal Society for a Wolfson Research Merit Award and ST is grateful to the John and Kathleen Watson Scholarship for financial support.
Fleming, Ian N. +2 more
core +1 more source
Radiofluorination Methods: Historical Overview and Current State
MEDICAL RADIOLOGY AND RADIATION SAFETY, 2022 1. Introduction 2. Radiofluorination methods for obtaining fluorine-18 radiopharmaceuticals 3. Electrophilic radiofluorination 4. Nucleophilic radiofluorination 5. Alternative radiofluorination methods 6.
A.V. Ozerskaya +8 more
openaire +1 more source
Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting [PDF]
, 2013 The formation of β-amyloid deposits is considered a histopathological feature of Alzheimer′s disease (AD). In vivo molecular imaging by means of amyloid-avid radiotracers will allow for an early and conclusive diagnostic of AD.
Abrunhosa, A. +6 more
core +1 more source