Results 51 to 60 of about 1,195 (160)

Electrochemically Generated Carbocations in Organic Synthesis

Angewandte Chemie, Volume 136, Issue 44, October 24, 2024.
This Minireview examines a selection of case studies that showcase distinctive and enabling electrochemical approaches that have allowed for the generation and reaction of carbocation intermediates under mild conditions. Particular emphasis is placed on the progress that has been made in this area of organic synthesis and polymer chemistry over the ...
Bill C. Hawkins, Justin M. Chalker, Michelle L. Coote, Alex C. Bissember   +3 more
wiley   +2 more sources

Preparation and Structure of Meta‐Hydroxy‐Substituted Aryliodonium Salts: New Structural Type of Phenol‐Derived Hypervalent Iodine Compounds

European Journal of Organic Chemistry, Volume 29, Issue 5, 7 February 2026.
The previously unknown meta‐hydroxy‐substituted aryliodonium salts were prepared by a two‐step one‐pot synthesis from 3‐acetoxy‐1‐[(diacetoxy)iodo]arenes and arylboronic acids. This procedure works well with halogen‐, methyl‐, methoxycarbonyl‐, or methoxy‐substituted arylboronic acids as well as naphthalenylboronic acids, phenanthren‐9‐ylboronic acid ...
Akira Yoshimura, Scott M. Larson, Mekhman S. Yusubov, Alexander V. Lyulyaev, Gregory T. Rohde, Tatuya Suzuki, Akiharu Ueki, Akio Saito, Viktor V. Zhdankin   +8 more
wiley   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco, Matthew Tredwell, Peter J. J. A. Buijnsters, Rhys Salter, Véronique Gouverneur   +13 more
wiley   +1 more source

Nucleophilic Radiofluorination Using Tri-tert-Butanol Ammonium as a Bifunctional Organocatalyst: Mechanism and Energetics

Molecules, 2022
We present a quantum chemical analysis of the 18F-fluorination of 1,3-ditosylpropane, promoted by a quaternary ammonium salt (tri-(tert-butanol)-methylammonium iodide (TBMA-I) with moderate to good radiochemical yields (RCYs), experimentally observed by ...
Young-Ho Oh, Sandip S. Shinde, Sungyul Lee   +2 more
doaj   +1 more source

Liquid Chromatography‐Tandem Mass Spectrometry Methods for Rapid Measurement of the Molar Activity (Am) of Cyclotron‐Produced [18F]Fluoride and Derived Radiotracers

Chemistry–Methods, Volume 6, Issue 1, January 2026.
Accurate and simple liquid chromatography‐tandem mass spectrometry methods for measuring Am for [18F]fluoride on two rapidly derived surrogates, [18F]FAY and [18F]PCBSF, can serve as forensic tools for investigating the sources of carrier, Am determinations during routine tracer productions and be applied to radiotracers lacking a strong ultraviolet ...
Nicholas R. Ellin, Sean W. Costner, Cheryl L. Morse, Fatemak Ahmadi, Sanjay Telu, Fabrice G. Siméon, Shuiyu Lu, H. Umesha Shetty, Victor W. Pike   +8 more
wiley   +1 more source

Closing the gap between 19F and 18F chemistry

EJNMMI Radiopharmacy and Chemistry, 2021
Positron emission tomography (PET) has become an invaluable tool for drug discovery and diagnosis. The positron-emitting radionuclide fluorine-18 is frequently used in PET radiopharmaceuticals due to its advantageous characteristics; hence, methods ...
Javier Ajenjo, Gianluca Destro, Bart Cornelissen, Véronique Gouverneur   +3 more
doaj   +1 more source

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Double‐Click Strategy Combining CuAAC and (Thia‐) Diels‐Alder Reactions; Application Toward Peptide Labeling

Chemistry – A European Journal, Volume 31, Issue 41, July 22, 2025.
A double click‐strategy combining copper‐catalyzed azide‐alkyne cycloaddition with (thia‐)Diels‐Alder reactions involving a reactive s‐cis‐constrained diene is reported. Three different one‐pot protocols (i.e., sequential or three‐component reactions) are proposed and offer valuable guidance for future applications.
Timothé Maujean, Camille Van Wesemael, Laurine Tual, Valentine Le Berruyer, Blanca Rodriguez‐Noguer, Nicolas Girard, Dominique Bonnet, Mihaela Gulea   +7 more
wiley   +1 more source

Nucleophilic Synthesis of 6-l-[¹⁸F]FDOPA. Is Copper-Mediated Radiofluorination the Answer?

Molecules, 2020
Positron emission tomography employing 6-l-[18F]fluoro-3,4-dihydroxyphenylalanine (6-l-[18F]FDOPA) is currently a highly relevant clinical tool for detection of gliomas, neuroendocrine tumors and evaluation of Parkinson’s disease progression.
Raisa N. Krasikova
doaj   +1 more source