Results 51 to 60 of about 1,138 (121)

Pioneering Metal‐Free Late‐Stage C−H Functionalization Using Acridinium Salt Photocatalysis

Chemistry – A European Journal, Volume 30, Issue 67, December 2, 2024.
Organic dyes are powerful photocatalysts in organic transformations due to their availability, adaptable absorption, and diverse structures. Acridinium‐based organo‐photocatalysts, notable for visible light responsiveness, efficiently functionalize inert C−H bonds under mild conditions without transition metals.
Shyamal Kanti Bera, Andrea Porcheddu
wiley   +1 more source

Design and Synthesis of an 18F-Labeled Version of Phenylethyl Orvinol ([18F]FE-PEO) for PET-Imaging of Opioid Receptors

Molecules, 2012
The semisynthetic oripavine derivative phenethyl orvinol (PEO), a full agonist at opioid receptors (OR), is an attractive structural motif for developing 18F-labeled PET tracers with a high degree of sensitivity for competition between endogenous and ...
Gjermund Henriksen, János Marton
doaj   +1 more source

Suppressing Protodeboronation in Cu‐Mediated 19F/18F‐Fluorination of Arylboronic Acids: A Mechanistically Guided Approach Towards Optimized PET Probe Development

Chemistry – A European Journal, Volume 30, Issue 55, October 1, 2024.
A method was rationally optimized to minimize deleterious protodeboronation side‐product in Cu‐mediated 19F‐ and 18F‐fluorination of arylboronic acids. Fluoride anion is activated through a hydrogen bond donor (HBD) effect under ligandless conditions featuring a new copper salt, Cu(ONf)2.
Jingkai Sun, Carolin Jaworski, Ralf Schirrmacher, Dennis G. Hall   +3 more
wiley   +1 more source

Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin

Molecules, 2019
There is an unmet need for late-stage 18F-fluorination strategies to label molecules with a wide range of relevant functionalities to medicinal chemistry, in particular (hetero)arenes, aiming to obtain unique in vivo information on the pharmacokinetics ...
Gonçalo S. Clemente, Tryfon Zarganes-Tzitzikas, Alexander Dömling, Philip H. Elsinga   +3 more
doaj   +1 more source

Rapid Electrophilic 211At‐Astatination of Trimethylgermyl Arenes

ChemPlusChem, Volume 89, Issue 9, September 2024.
211At‐Astatodegermylation: Different ortho‐, meta‐, and para‐substituted trimethylgermyl arenes were astatinated at low precursor amounts (0.15 μmol) in trifluoroacetic acid with an average radiochemical conversion (RCC) of ca. 50 % for electron‐rich and approx. 70 % in case of electron‐deficient arenes.
Marius Müller, Umberto Maria Battisti, Merlin Zabrocki, Ellinor Hansson, Holger Jensen, Emma Aneheim, Sture Lindegren, Matthias Manfred Herth   +7 more
wiley   +1 more source

Preparation and Preclinical Evaluation of ¹⁸F-Labeled Olutasidenib Derivatives for Non-Invasive Detection of Mutated Isocitrate Dehydrogenase 1 (mIDH1)

Molecules
Mutations of isocitrate dehydrogenase 1 (IDH1) are key biomarkers for glioma classification, but current methods for detection of mutated IDH1 (mIDH1) require invasive tissue sampling and cannot be used for longitudinal studies.
Roberta Cologni, Marcus Holschbach, Daniela Schneider, Dirk Bier, Annette Schulze, Carina Stegmayr, Heike Endepols, Johannes Ermert, Felix Neumaier, Bernd Neumaier   +9 more
doaj   +1 more source

Potential of miRNA as Imaging Targets for PET

Helvetica Chimica Acta, Volume 107, Issue 8, August 2024.
Abstract Positron Emission Tomography (PET) is an important part of the medical imaging field which is continually exploring novel biological targets as exemplified by PET imaging of neuroinflammation. Due to limitations stemming from either sub‐optimal biological targets or a lack of available selective radiotracers, alternative biomarkers and PET ...
Simon H. Zientek, Stephen Thompson, Franklin I. Aigbirhio, Selena Milicevic Sephton   +3 more
wiley   +1 more source

Development of a novel radioligand for imaging 18-kD translocator protein (TSPO) in a rat model of Parkinson’s disease

BMC Medical Imaging, 2019
Purpose The inflammation reaction in the brain may stimulate damage repair or possibly lead to secondary brain injury. It is often associated with activated microglia, which would overexpress 18-kDa translocator protein (TSPO).
Chun-Yi Wu, Yang-Yi Chen, Jia-Jia Lin, Jui-Ping Li, Jen-Kun Chen, Te-Chun Hsieh, Chia-Hung Kao   +6 more
doaj   +1 more source

Synthesis of 18F‐labeled Aryl Trifluoromethyl Sulfones, ‐Sulfoxides, and ‐Sulfides for Positron Emission Tomography

Angewandte Chemie, Volume 136, Issue 27, July 1, 2024.
The mild and high‐yielding synthesis of 18F‐labeled aryl trifluoromethyl sulfones, ‐sulfoxides, and ‐sulfides using [18F]Ruppert‐Prakash reagent is described. The application to the radiolabeling of different bioactive compounds using >1 GBq of 18F‐labeling reagent is demonstrated.
Lukas Veth, Albert D. Windhorst, Danielle J. Vugts   +2 more
wiley   +1 more source

Revisiting the Radiosynthesis of [¹⁸F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease

Molecules, 2020
[18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS).
Cassis Varlow, Emily Murrell, Jason P. Holland, Alina Kassenbrock, Whitney Shannon, Steven H. Liang, Neil Vasdev, Nickeisha A. Stephenson   +7 more
doaj   +1 more source