Results 61 to 70 of about 1,169 (122)
Pioneering Metal‐Free Late‐Stage C−H Functionalization Using Acridinium Salt Photocatalysis
Chemistry – A European Journal, Volume 30, Issue 67, December 2, 2024.Organic dyes are powerful photocatalysts in organic transformations due to their availability, adaptable absorption, and diverse structures. Acridinium‐based organo‐photocatalysts, notable for visible light responsiveness, efficiently functionalize inert C−H bonds under mild conditions without transition metals.
Shyamal Kanti Bera, Andrea Porcheddu
wiley +1 more source
Molecules, 2012 The semisynthetic oripavine derivative phenethyl orvinol (PEO), a full agonist at opioid receptors (OR), is an attractive structural motif for developing 18F-labeled PET tracers with a high degree of sensitivity for competition between endogenous and ...
Gjermund Henriksen, János Marton
doaj +1 more source
Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin
Molecules, 2019 There is an unmet need for late-stage 18F-fluorination strategies to label molecules with a wide range of relevant functionalities to medicinal chemistry, in particular (hetero)arenes, aiming to obtain unique in vivo information on the pharmacokinetics ...
Gonçalo S. Clemente +3 more
doaj +1 more source
Chemistry – A European Journal, Volume 30, Issue 55, October 1, 2024.A method was rationally optimized to minimize deleterious protodeboronation side‐product in Cu‐mediated 19F‐ and 18F‐fluorination of arylboronic acids. Fluoride anion is activated through a hydrogen bond donor (HBD) effect under ligandless conditions featuring a new copper salt, Cu(ONf)2.
Jingkai Sun +3 more
wiley +1 more source
MoleculesMutations of isocitrate dehydrogenase 1 (IDH1) are key biomarkers for glioma classification, but current methods for detection of mutated IDH1 (mIDH1) require invasive tissue sampling and cannot be used for longitudinal studies.
Roberta Cologni +9 more
doaj +1 more source
Rapid Electrophilic 211At‐Astatination of Trimethylgermyl Arenes
ChemPlusChem, Volume 89, Issue 9, September 2024.211At‐Astatodegermylation: Different ortho‐, meta‐, and para‐substituted trimethylgermyl arenes were astatinated at low precursor amounts (0.15 μmol) in trifluoroacetic acid with an average radiochemical conversion (RCC) of ca. 50 % for electron‐rich and approx. 70 % in case of electron‐deficient arenes.
Marius Müller +7 more
wiley +1 more source
BMC Medical Imaging, 2019 Purpose The inflammation reaction in the brain may stimulate damage repair or possibly lead to secondary brain injury. It is often associated with activated microglia, which would overexpress 18-kDa translocator protein (TSPO).
Chun-Yi Wu +6 more
doaj +1 more source
Potential of miRNA as Imaging Targets for PET
Helvetica Chimica Acta, Volume 107, Issue 8, August 2024.Abstract Positron Emission Tomography (PET) is an important part of the medical imaging field which is continually exploring novel biological targets as exemplified by PET imaging of neuroinflammation. Due to limitations stemming from either sub‐optimal biological targets or a lack of available selective radiotracers, alternative biomarkers and PET ...
Simon H. Zientek +3 more
wiley +1 more source
Molecules, 2013 With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3 ...
Simon M. Ametamey +6 more
doaj +1 more source
Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents
BMC Cancer, 2019 Background The recent implementation of PET with prostate specific membrane antigen (PSMA)-specific radiotracers into the clinical practice has resulted in the significant improvement of accuracy in the detection of prostate carcinoma (PCa).
Heike Endepols +8 more
doaj +1 more source