Results 61 to 70 of about 2,508 (203)

A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [¹⁸F]fluoride: Will [¹⁸F]AlF Replace ⁶⁸Ga for Metal Chelate Labeling?

Molecules, 2019
Due to its ideal physical properties, fluorine-18 turns out to be a key radionuclide for positron emission tomography (PET) imaging, for both preclinical and clinical applications.
Cyril Fersing, Ahlem Bouhlel, Christophe Cantelli, Philippe Garrigue, Vincent Lisowski, Benjamin Guillet   +5 more
doaj   +1 more source

Synthesis of [ 18 F]fluoroethoxy‐benzovesamicol, a radiotracer for cholinergic neurons [PDF]

, 1993
Full experimental details are given for the preparation of [ 18 F]fluoroethoxy‐benzovesamicol, (−)‐( 2R, 3R )‐ trans ‐2‐hydroxy‐3‐(4‐phenylpiperidino)‐5‐(2‐[ 18 F]fluoroethoxy)‐1,2,3,4‐tetralin, a new fluorine‐18 labeled cholinergic neuron mapping agent ...
Altar, Block, Block, Chi, Dale, Efange, French, Hicks, Jerabek, Jung, Keisewetter, Kiesewetter, Kilbourn, Lemaire, Marien, Marshall, Moerlein, Mulholland, Mulholland, Mulholland, Mulholland, Mulholland, Mulholland, Plenevaux, Rogers, Rogers, Rogers, Rogers, Satymurthy, Shuie, Suehiro, Widen   +31 more
core   +1 more source

Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production. [PDF]

, 2018
The development of new positron-emission tomography (PET) tracers is enabling researchers and clinicians to image an increasingly wide array of biological targets and processes.
Collins, Jeffrey, Drake, Christopher, Schopf, Eric, Slavik, Roger, van Dam, R Michael, Waldmann, Christopher M   +5 more
core  

Untersuchungen zur trägerarmen Radiofluorierung nicht-aktivierter Aromaten mit n.c.a. [18F]Fluorid [PDF]

, 2011
In vivo imaging with positron emission tomography generally demands radiotracers with a high specific activity. In case of fluorine-18 the required no-carrier-added (n.c.a.) starting material is only available in form of fluoride. This and the short half-
Cardinale, Jens
core  

Electrochemically Generated Carbocations in Organic Synthesis

Angewandte Chemie, Volume 136, Issue 44, October 24, 2024.
This Minireview examines a selection of case studies that showcase distinctive and enabling electrochemical approaches that have allowed for the generation and reaction of carbocation intermediates under mild conditions. Particular emphasis is placed on the progress that has been made in this area of organic synthesis and polymer chemistry over the ...
Bill C. Hawkins, Justin M. Chalker, Michelle L. Coote, Alex C. Bissember   +3 more
wiley   +2 more sources

Solid-phase supported direct 18F-radiofluorination of peptides [PDF]

Bioorganic & Medicinal Chemistry Letters
The absence of universal and expedient labeling procedures hampers the widespread application of peptides as molecular tracers for positron emission tomography (PET). In this work, we have developed a proof-of-concept direct radiofluorination procedure for peptides using conventional solid-phase peptide synthesis.
Eduardo F.A. Fernandes, Line B.S. Knudsen, Andreas Kjaer, Kristian Strømgaard, Matthias M. Herth   +4 more
openaire   +2 more sources

Preparation and Structure of Meta‐Hydroxy‐Substituted Aryliodonium Salts: New Structural Type of Phenol‐Derived Hypervalent Iodine Compounds

European Journal of Organic Chemistry, Volume 29, Issue 5, 7 February 2026.
The previously unknown meta‐hydroxy‐substituted aryliodonium salts were prepared by a two‐step one‐pot synthesis from 3‐acetoxy‐1‐[(diacetoxy)iodo]arenes and arylboronic acids. This procedure works well with halogen‐, methyl‐, methoxycarbonyl‐, or methoxy‐substituted arylboronic acids as well as naphthalenylboronic acids, phenanthren‐9‐ylboronic acid ...
Akira Yoshimura, Scott M. Larson, Mekhman S. Yusubov, Alexander V. Lyulyaev, Gregory T. Rohde, Tatuya Suzuki, Akiharu Ueki, Akio Saito, Viktor V. Zhdankin   +8 more
wiley   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Imaging Microglial/Macrophage Activation in Spinal Cords of Experimental Autoimmune Encephalomyelitis Rats by Positron Emission Tomography Using the Mitochondrial 18kDa Translocator Protein Radioligand [18F]DPA-714 [PDF]

, 2012
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding animal models, experimental autoimmune encephalomyelitis (EAE).
Abourbeh, Galith, Boisgard, Raphael, Brulon, Vincent, Dollé, Frédéric, Dubois, Albertine, Fontyn, Yoann, Maroy, Renaud, Tavitian, Bertrand, Thézé, Benoit   +8 more
core   +2 more sources

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco, Matthew Tredwell, Peter J. J. A. Buijnsters, Rhys Salter, Véronique Gouverneur   +13 more
wiley   +1 more source