Results 71 to 80 of about 2,508 (203)

[¹⁸F]-Radiolabelled Nanoplatforms: A Critical Review of Their Intrinsic Characteristics, Radiolabelling Methods, and Purification Techniques

Molecules
A wide range of nano-objects is found in many applications of our everyday life. Recognition of their peculiar properties and ease of functionalization has prompted their engineering into multifunctional platforms that are supposed to afford efficient ...
Maëlle Deleuziere, Éric Benoist, Isabelle Quelven, Emmanuel Gras, Catherine Amiens   +4 more
doaj   +1 more source

Использование соединений поливалентного иода в получении [18F]фторсодержащих трейсеров для позитронной эмиссионной томографии [PDF]

, 2011
Впервые проведен анализ научной литературы по использованию соединений поливалентного иода в синтезе прекурсоров - иодониевых солей для введения атома [18F]фтора в структуру органических ...
Дрыгунова, Лариса Александровна, Ларькина, Мария Сергеевна, Юсубов, Мехман Сулейман-оглы (Сулейманович)   +2 more
core   +2 more sources

Catalyst-Free Aromatic Radiofluorination via Oxidized Iodoarene Precursors

Organic Letters, 2018
Oxidized iodoarenes (OIAs), prepared via mCPBA-mediated oxidation, have been demonstrated as versatile precursors for the synthesis of [18F]fluoroarenes in the absence of catalysts. OIAs have been identified as intermediates in single-pot syntheses of iodonium salts and ylides but have never been recognized as radiofluorination precursors.
Young-Do Kwon, Jeongmin Son, Joong-Hyun Chun   +2 more
openaire   +3 more sources

Nucleophilic Radiofluorination Using Tri-tert-Butanol Ammonium as a Bifunctional Organocatalyst: Mechanism and Energetics

Molecules, 2022
We present a quantum chemical analysis of the 18F-fluorination of 1,3-ditosylpropane, promoted by a quaternary ammonium salt (tri-(tert-butanol)-methylammonium iodide (TBMA-I) with moderate to good radiochemical yields (RCYs), experimentally observed by ...
Young-Ho Oh, Sandip S. Shinde, Sungyul Lee   +2 more
doaj   +1 more source

Liquid Chromatography‐Tandem Mass Spectrometry Methods for Rapid Measurement of the Molar Activity (Am) of Cyclotron‐Produced [18F]Fluoride and Derived Radiotracers

Chemistry–Methods, Volume 6, Issue 1, January 2026.
Accurate and simple liquid chromatography‐tandem mass spectrometry methods for measuring Am for [18F]fluoride on two rapidly derived surrogates, [18F]FAY and [18F]PCBSF, can serve as forensic tools for investigating the sources of carrier, Am determinations during routine tracer productions and be applied to radiotracers lacking a strong ultraviolet ...
Nicholas R. Ellin, Sean W. Costner, Cheryl L. Morse, Fatemak Ahmadi, Sanjay Telu, Fabrice G. Siméon, Shuiyu Lu, H. Umesha Shetty, Victor W. Pike   +8 more
wiley   +1 more source

Synthesis of 18F‐labeled Aryl Trifluoromethyl Sulfones, ‐Sulfoxides, and ‐Sulfides for Positron Emission Tomography

Angewandte Chemie, Volume 136, Issue 27, July 1, 2024.
The mild and high‐yielding synthesis of 18F‐labeled aryl trifluoromethyl sulfones, ‐sulfoxides, and ‐sulfides using [18F]Ruppert‐Prakash reagent is described. The application to the radiolabeling of different bioactive compounds using >1 GBq of 18F‐labeling reagent is demonstrated.
Lukas Veth, Albert D. Windhorst, Danielle J. Vugts   +2 more
wiley   +2 more sources

τBu₂SiF-Derivatized D₂-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging [PDF]

, 2011
The synthesis, radiolabeling and in vitro evaluation of new silicon-fluoride acceptor (SiFA) derivatized D-2-receptor ligands is reported. The SiFA-technology simplifies the introduction of fluorine-18 into target specific biomolecules for Positron ...
Bartenstein, Peter, Höfner, Georg, Iovkova-Berends, Ljuba, Jurkschat, Klaus, Kostikov, Alexey, Rensch, Christian, Schirrmacher, Ralf, Wanner, Klaus Theodor, Wängler, Björn, Wängler, Carmen, Zöller, Thomas   +10 more
core   +2 more sources

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Intestinal absorption of glucose in mice as determined by positron emission tomography. [PDF]

, 2018
KEY POINTS:The goal was to determine the importance of the sodium-glucose cotransporter SGLT1 and the glucose uniporter GLUT2 in intestinal glucose absorption during oral glucose tolerance tests (OGTTs) in mice.
Bindslev, Casteleyn, Chow, Debnam, Gallo, Ghezzi, Ghezzi, Gorboulev, Grundy, Guillam, Hediger, Holst, Hummel, James, Kayano, Kellett, Kellett, Kreissl, Kuhre, Loening, Madunic, Mudie, Powell, Rizza, Roder, Sala-Rabanal, Santer, Schmitt, Stumpel, Suckow, Thorens, Thorens, Wong, Wright, Wright, Yamashita, Yu, Yu   +37 more
core   +1 more source

Double‐Click Strategy Combining CuAAC and (Thia‐) Diels‐Alder Reactions; Application Toward Peptide Labeling

Chemistry – A European Journal, Volume 31, Issue 41, July 22, 2025.
A double click‐strategy combining copper‐catalyzed azide‐alkyne cycloaddition with (thia‐)Diels‐Alder reactions involving a reactive s‐cis‐constrained diene is reported. Three different one‐pot protocols (i.e., sequential or three‐component reactions) are proposed and offer valuable guidance for future applications.
Timothé Maujean, Camille Van Wesemael, Laurine Tual, Valentine Le Berruyer, Blanca Rodriguez‐Noguer, Nicolas Girard, Dominique Bonnet, Mihaela Gulea   +7 more
wiley   +1 more source