Results 71 to 80 of about 1,195 (160)

Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents

BMC Cancer, 2019
Background The recent implementation of PET with prostate specific membrane antigen (PSMA)-specific radiotracers into the clinical practice has resulted in the significant improvement of accuracy in the detection of prostate carcinoma (PCa).
Heike Endepols, Agnieszka Morgenroth, Boris D. Zlatopolskiy, Philipp Krapf, Johannes Zischler, Raphael Richarz, Sergio Muñoz Vásquez, Bernd Neumaier, Felix M. Mottaghy   +8 more
doaj   +1 more source

Copper-Mediated Radiofluorination of Arylstannanes with [¹⁸F]KF

Organic Letters, 2016
A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [18F]KF is described. This method is fast, uses commercially available reagents, and is compatible with both electron-rich and electron-deficient arene substrates. This method has been applied to the manual synthesis of a variety of clinically relevant radiotracers ...
Makaravage, Katarina J., Brooks, Allen F., Mossine, Andrew V., Sanford, Melanie S., Scott, Peter J. H.   +4 more
openaire   +2 more sources

Synthesis of a [¹⁸F]F Estradiol Derivative via Click Chemistry Using an Automated Synthesis Module: In Vitro Evaluation as Potential Radiopharmaceutical for Breast Cancer Imaging

Pharmaceuticals
“Click reactions” are a very useful tool for the selective conjugation of different molecular subunits to produce complex structures in a simple way. In this paper, we present the application of Cu(I)-catalyzed biorthogonal reactions between alkynes and ...
María Emilia Tejería, María Pía Pereira, Juan Pablo Gambini, Pablo Duarte, Javier Gabriel Giglio, Ana María Rey   +5 more
doaj   +1 more source

Late-stage (radio)fluorination of alkyl phosphonates via electrophilic activation

Nature Communications
Constructing organic fluorophosphines, vital drug skeletons, through the direct fluorination of readily available alkyl phosphonates has been impeded due to the intrinsic low electrophilicity of PV and the high bond energy of P═O bond.
Kaiqiang Zhang, Wanru Feng, Zhaobiao Mou, Lei Zhang, Mengting Ma, Zixiao Zhao, Xia Liu, Xiaoyuan Chen, Zijing Li   +8 more
doaj   +1 more source

Radiofluorination of squalenoylated drug analogues

, 2018
The conjugation of drugs with squalene derivatives has found wide spread application due to the ability of the conjugates to form nanoparticles in aqueous solutions. The conjugated drugs exhibit increased bioavailability and effectiveness against the targeted disease.
openaire   +2 more sources

Automated radiosynthesis of [18F]fluoromannitol for clinical research on a commercially available trasis allinone radiosynthesizer

EJNMMI Radiopharmacy and Chemistry
Background Infections pose a significant risk to immunocompromised individuals, and accurate, efficient diagnosis remain challenging. Current imaging methods like MRI and FDG PET lack pathogen specificity which complicate diagnosis and lead to overuse of
Amy L. Vāvere, Allison J. Clay, Arijit Ghosh, Joana Marie Almazan, Melissa J. Brown, Spenser Simpson, Kiel D. Neumann   +6 more
doaj   +1 more source

Solid-phase supported direct 18F-radiofluorination of peptides

Bioorganic & Medicinal Chemistry Letters
The absence of universal and expedient labeling procedures hampers the widespread application of peptides as molecular tracers for positron emission tomography (PET). In this work, we have developed a proof-of-concept direct radiofluorination procedure for peptides using conventional solid-phase peptide synthesis.
Eduardo F.A. Fernandes, Line B.S. Knudsen, Andreas Kjaer, Kristian Strømgaard, Matthias M. Herth   +4 more
openaire   +3 more sources

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

EJNMMI Radiopharmacy and Chemistry
Background (S)-[18F]FETrp is a promising PET radiotracer for imaging IDO1 activity, one of the main enzymes involved in the tryptophan metabolism that plays a key role in several diseases including cancers.
Aurélie Maisonial-Besset, David Kryza, Klaus Kopka, Sophie Levesque, Emmanuel Moreau, Barbara Wenzel, Jean-Michel Chezal   +6 more
doaj   +1 more source

Triarylselenonium triflates provide efficient access to no-carrier-added <i>ortho</i>-, <i>meta</i>-, and <i>para</i>-[¹⁸F]Fluoroarenes. [PDF]

Chem Sci
Sypniewski J, Lee YS, Tran P, Costner S, Siméon FG, Pike VW.   +5 more
europepmc   +1 more source

¹⁸F-labelling of (hetero)aryl halides <i>via</i> sequential Miyaura borylation/copper-mediated radiofluorination. [PDF]

Chem Sci
Noel AN, Greco SG, Horikawa M, Spiller TE, Nichols DL, Witek JA, Brooks AF, Scott PJH, Sanford MS.   +8 more
europepmc   +1 more source