Results 71 to 80 of about 1,169 (122)

Synthesis of a [¹⁸F]F Estradiol Derivative via Click Chemistry Using an Automated Synthesis Module: In Vitro Evaluation as Potential Radiopharmaceutical for Breast Cancer Imaging

Pharmaceuticals
“Click reactions” are a very useful tool for the selective conjugation of different molecular subunits to produce complex structures in a simple way. In this paper, we present the application of Cu(I)-catalyzed biorthogonal reactions between alkynes and ...
María Emilia Tejería, María Pía Pereira, Juan Pablo Gambini, Pablo Duarte, Javier Gabriel Giglio, Ana María Rey   +5 more
doaj   +1 more source

Late-stage (radio)fluorination of alkyl phosphonates via electrophilic activation

Nature Communications
Constructing organic fluorophosphines, vital drug skeletons, through the direct fluorination of readily available alkyl phosphonates has been impeded due to the intrinsic low electrophilicity of PV and the high bond energy of P═O bond.
Kaiqiang Zhang, Wanru Feng, Zhaobiao Mou, Lei Zhang, Mengting Ma, Zixiao Zhao, Xia Liu, Xiaoyuan Chen, Zijing Li   +8 more
doaj   +1 more source

Automated radiosynthesis of [18F]fluoromannitol for clinical research on a commercially available trasis allinone radiosynthesizer

EJNMMI Radiopharmacy and Chemistry
Background Infections pose a significant risk to immunocompromised individuals, and accurate, efficient diagnosis remain challenging. Current imaging methods like MRI and FDG PET lack pathogen specificity which complicate diagnosis and lead to overuse of
Amy L. Vāvere, Allison J. Clay, Arijit Ghosh, Joana Marie Almazan, Melissa J. Brown, Spenser Simpson, Kiel D. Neumann   +6 more
doaj   +1 more source

Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer

EJNMMI Radiopharmacy and Chemistry
Background Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the prosthetic group (PG) [18F]SFB
Herlinde Dierick, Laurent Navarro, Hannelore Ceuppens, Thomas Ertveldt, Ana Rita Pombo Antunes, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot, Matthias D’Huyvetter, Tony Lahoutte, Vicky Caveliers, Jessica Bridoux   +11 more
doaj   +1 more source

Preclinical validation of AMPDA-HB derivatives integrating Hsp70-specific TPP motif and anti-CD2 single domain antibody radiolabeled by Al

European Journal of Medicinal Chemistry Reports
Background: Al(III) complexes are gaining increasing interest for their potential use in Positron Emission Tomography (PET) imaging by formation of ternary complexes with the radioisotope fluorine-18 ( 18 F).
Lisa Russelli, Jonathan Martinelli, Adriano Bolognani, Rachele Stefania, Dario Gosmann, Stephan Stangl, Angela M. Krackhardt, Gabriele Multhoff, Lorenzo Tei, Calogero D'Alessandria   +9 more
doaj   +1 more source

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

EJNMMI Radiopharmacy and Chemistry
Background (S)-[18F]FETrp is a promising PET radiotracer for imaging IDO1 activity, one of the main enzymes involved in the tryptophan metabolism that plays a key role in several diseases including cancers.
Aurélie Maisonial-Besset, David Kryza, Klaus Kopka, Sophie Levesque, Emmanuel Moreau, Barbara Wenzel, Jean-Michel Chezal   +6 more
doaj   +1 more source

Triarylselenonium triflates provide efficient access to no-carrier-added <i>ortho</i>-, <i>meta</i>-, and <i>para</i>-[¹⁸F]Fluoroarenes. [PDF]

Chem Sci
Sypniewski J, Lee YS, Tran P, Costner S, Siméon FG, Pike VW.   +5 more
europepmc   +1 more source

¹⁸F-labelling of (hetero)aryl halides <i>via</i> sequential Miyaura borylation/copper-mediated radiofluorination. [PDF]

Chem Sci
Noel AN, Greco SG, Horikawa M, Spiller TE, Nichols DL, Witek JA, Brooks AF, Scott PJH, Sanford MS.   +8 more
europepmc   +1 more source

Deoxyradiofluorination of Phenols via a Difluoromethoxy Nucleofuge Enabled by Organic Photoredox Catalysis. [PDF]

ACS Cent Sci
Mungalpara MN, Wu X, Ma X, Zhu Z, Jiang M, Pike VW, Lu S, Zhang H, Wu Z, Kinon PO, Huang Y, Nicewicz DA, Li Z.   +12 more
europepmc   +1 more source

Optimization of [¹⁸F]FBPA production for clinical translation through precursor development and manufacturing route evaluation. [PDF]

EJNMMI Radiopharm Chem
Chang TY, Yu YH, You ZF, Cho PC, Wang YF, Wu CY.   +5 more
europepmc   +1 more source