Results 91 to 100 of about 2,508 (203)

Rapid Electrophilic 211At‐Astatination of Trimethylgermyl Arenes

ChemPlusChem, Volume 89, Issue 9, September 2024.
211At‐Astatodegermylation: Different ortho‐, meta‐, and para‐substituted trimethylgermyl arenes were astatinated at low precursor amounts (0.15 μmol) in trifluoroacetic acid with an average radiochemical conversion (RCC) of ca. 50 % for electron‐rich and approx. 70 % in case of electron‐deficient arenes.
Marius Müller, Umberto Maria Battisti, Merlin Zabrocki, Ellinor Hansson, Holger Jensen, Emma Aneheim, Sture Lindegren, Matthias Manfred Herth   +7 more
wiley   +1 more source

Zur Synthese von 6[18F]Fluor-L-DOPA durch nukleophile 18F-Fluorierung Carbonyl-aktivierter aromatischer Aminosäurederivate [PDF]

, 2001
6-[$^{18}$F]Fluoro-L-3,4-dihydroxyphenylalanine (6-[$^{18}$F]fluoro-L-DOPA), an analogue of L-DOPA, is an established radiotracer for diagnostic PET-studies of the integrity and function of the nigrostriatal dopaminergic system. The use of this important
Tierling, Thomas
core  

Automated radiosynthesis of Al[18F]PSMA-11 for large scale routine use. [PDF]

, 2018
Objectives: We report a reproducible automated radiosynthesis for large scale batch production of clinical grade Al[F-18]PSMA-11. Methods: A SynthraFCHOL module was optimized to synthesize Al[F-18]PSMA-11 by Al[F-18]-chelation.
Brans, Boudewijn, Courtyn, Jan, De Man, Kathia, De Vos, Filip, Kersemans, Ken, Moerman, Lieselotte, Piron, Sarah, Van Royen, Tessa   +7 more
core   +1 more source

Potential of miRNA as Imaging Targets for PET

Helvetica Chimica Acta, Volume 107, Issue 8, August 2024.
Abstract Positron Emission Tomography (PET) is an important part of the medical imaging field which is continually exploring novel biological targets as exemplified by PET imaging of neuroinflammation. Due to limitations stemming from either sub‐optimal biological targets or a lack of available selective radiotracers, alternative biomarkers and PET ...
Simon H. Zientek, Stephen Thompson, Franklin I. Aigbirhio, Selena Milicevic Sephton   +3 more
wiley   +1 more source

Preparation and Preclinical Evaluation of ¹⁸F-Labeled Olutasidenib Derivatives for Non-Invasive Detection of Mutated Isocitrate Dehydrogenase 1 (mIDH1)

Molecules
Mutations of isocitrate dehydrogenase 1 (IDH1) are key biomarkers for glioma classification, but current methods for detection of mutated IDH1 (mIDH1) require invasive tissue sampling and cannot be used for longitudinal studies.
Roberta Cologni, Marcus Holschbach, Daniela Schneider, Dirk Bier, Annette Schulze, Carina Stegmayr, Heike Endepols, Johannes Ermert, Felix Neumaier, Bernd Neumaier   +9 more
doaj   +1 more source

Development of a novel radioligand for imaging 18-kD translocator protein (TSPO) in a rat model of Parkinson’s disease

BMC Medical Imaging, 2019
Purpose The inflammation reaction in the brain may stimulate damage repair or possibly lead to secondary brain injury. It is often associated with activated microglia, which would overexpress 18-kDa translocator protein (TSPO).
Chun-Yi Wu, Yang-Yi Chen, Jia-Jia Lin, Jui-Ping Li, Jen-Kun Chen, Te-Chun Hsieh, Chia-Hung Kao   +6 more
doaj   +1 more source

Development new radiopharmaceutical based on 5-thio-d- glucose labeled technetium-99m [PDF]

, 2016
The article considers the obtaining and possibility of using 5-thio-D-glucose labeled technetium-99m for the diagnosis of malignant tumors by single photon emission computed tomography.
Ilina, Elena Sergeevna, Larionova, Lyudmila Aleksandrovna, Nesterov, Evgeny Alexandrovich, Rogov, Alexander Sergeyevich, Sadkin, Vladimir Leonidovich, Skuridin, Viktor Sergeyevich, Stasyuk (Stasiuk), Elena Sergeyevna, Varlamova, Natalya Valeryevna, Zelchan, R.   +8 more
core   +1 more source

Revisiting the Radiosynthesis of [¹⁸F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease

Molecules, 2020
[18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS).
Cassis Varlow, Emily Murrell, Jason P. Holland, Alina Kassenbrock, Whitney Shannon, Steven H. Liang, Neil Vasdev, Nickeisha A. Stephenson   +7 more
doaj   +1 more source

Synthese und trägerarme Radiofluorierung von A2A-Adenosin-Rezeptorliganden für die Positronen-Emissions-Tomographie [PDF]

, 2017
The A$_{2A}$ adenosine receptor (A$_{2A}$AR) localized in the brain has important roles in the regulationof glutamate and dopamine release. In several brain disorders like Parkinson`s disease theexpression profile of A$_{2A}$AR is altered which can be ...
Skraban, Marcel Alexander René
core  

Lack of neuroinflammation in the HIV-1 transgenic rat: An [18 F]-DPA714 PET imaging study [PDF]

, 2015
BACKGROUND: HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND).
Hammoud, Dima A, Ibrahim, Wael G, Jagoda, Elaine M, Kassiou, Michael, Lee, Dianne E, Lentz, Margaret R, Maric, Dragan, Peterson, Kristin L, Reid, William C, Yue, Xuyi   +9 more
core   +2 more sources