Results 111 to 120 of about 2,508 (203)

Late-stage (radio)fluorination of alkyl phosphonates via electrophilic activation

Nature Communications
Constructing organic fluorophosphines, vital drug skeletons, through the direct fluorination of readily available alkyl phosphonates has been impeded due to the intrinsic low electrophilicity of PV and the high bond energy of P═O bond.
Kaiqiang Zhang, Wanru Feng, Zhaobiao Mou, Lei Zhang, Mengting Ma, Zixiao Zhao, Xia Liu, Xiaoyuan Chen, Zijing Li   +8 more
doaj   +1 more source

Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). [PDF]

, 2019
BackgroundConventional scale production of small batches of PET tracers (e.g. for preclinical imaging) is an inefficient use of resources. Using O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), we demonstrate that simple microvolume radiosynthesis ...
Chen, Bao Ying, Clark, Peter M, Fong, Kelly Mun-Ming, Lisova, Ksenia, van Dam, R Michael, Wang, Jia   +5 more
core   +1 more source

Automated radiosynthesis of [18F]fluoromannitol for clinical research on a commercially available trasis allinone radiosynthesizer

EJNMMI Radiopharmacy and Chemistry
Background Infections pose a significant risk to immunocompromised individuals, and accurate, efficient diagnosis remain challenging. Current imaging methods like MRI and FDG PET lack pathogen specificity which complicate diagnosis and lead to overuse of
Amy L. Vāvere, Allison J. Clay, Arijit Ghosh, Joana Marie Almazan, Melissa J. Brown, Spenser Simpson, Kiel D. Neumann   +6 more
doaj   +1 more source

Nukleophile Kupfer-Vermittelte Radiofluorierung von L-Tryptophan-Derivaten [PDF]

, 2017
$^{18}$F-Labeled aromatic amino acids became more and more important for molecular imgaging withPositron Emission Tomography (PET). Several examples have emerged showing higherspecificity in imaging disorders in neurological processes or tumors.
Schäfer, Dominique Christian
core  

Peptides Radiofluorination: Main Methods and Highlights

International Journal of Organic Chemistry, 2022
Ana Carolina A. Bispo, Fernanda A. F. Almeida, Juliana B. Silva, Marcelo Mamede   +3 more
openaire   +1 more source

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

EJNMMI Radiopharmacy and Chemistry
Background (S)-[18F]FETrp is a promising PET radiotracer for imaging IDO1 activity, one of the main enzymes involved in the tryptophan metabolism that plays a key role in several diseases including cancers.
Aurélie Maisonial-Besset, David Kryza, Klaus Kopka, Sophie Levesque, Emmanuel Moreau, Barbara Wenzel, Jean-Michel Chezal   +6 more
doaj   +1 more source

Automated synthesis and PET evaluation of both enantiomers of [18F]FMISO [PDF]

, 2015
Hansen, Anders Elias, Jensen, Andreas Tue Ingemann, Jørgensen, Jesper T., Kjær, Andreas, Revunov, Evgeny V., Severin, Gregory, Zhuravlev, Fedor   +6 more
core   +1 more source

Synthesis and radiofluorination of putative NMDA receptor ligands

, 2010
In the course of this work on the synthesis of radioligands for the NMDA receptor the authentic standards and labeling precursors of four compounds with an amidine structure was performed. Synthesis of the precursors followed reaction conditions given in the literature and was successful.
openaire   +3 more sources

On the Risk of ¹⁸F-Regioisomer Formation in the Copper-Free Radiofluorination of Aryliodonium Precursors. [PDF]

Org Lett, 2023
Zhao Q, Etersque JM, Lu S, Telu S, Pike VW.   +4 more
europepmc   +1 more source

Streamlined Radiosynthesis of [¹⁸F]Fluproxadine (AF78): An Unprotected Guanidine Precursor Enables Efficient One-Step, Automation-Ready Labeling for Clinical Use. [PDF]

Pharmaceutics
Chen X, Ohta K, Kimura H, Yagi Y, Sasaki T, Nose N, Akehi M, Yamane T, Werner RA, Higuchi T.   +9 more
europepmc   +1 more source