Nucleophilic radiofluorination at room temperature via aziridinium intermediates
RSC Adv., 2014 2-Fluoroamines were synthesized at RT from alcohols with different sources of nucleophilic [18F]- or [19F]-fluoride.
Médoc, M, Sobrio, F
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Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor [PDF]
, 2017 P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer’s disease. This study reports the first design, synthesis, radiolabeling and biological evaluation
Gao, Mingzhang +7 more
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Molecules, 2013 With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3 ...
Simon M. Ametamey +6 more
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Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18. [PDF]
Positron emission tomography (PET) is unique in that it allows quantification of biochemical processes in vivo, but difficulties with preparing suitably labelled radiotracers limit its scientific and diagnostic applications.
Cybulska, K +6 more
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Radiofluorination of squalenoylated drug analogues
, 2018 The conjugation of drugs with squalene derivatives has found wide spread application due to the ability of the conjugates to form nanoparticles in aqueous solutions. The conjugated drugs exhibit increased bioavailability and effectiveness against the targeted disease.
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Development of radiosynthesis methods for 18F-labelled radiopharmaceuticals : General considerations and production of a dopamine transporter radioligand [PDF]
, 2011 Positron emission tomography (PET) is a molecular imaging technique that utilises radiopharmaceuticals (radiotracers) labelled with a positron-emitting radionuclide, such as fluorine-18 (18F).
Koivula, Teija
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Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents
BMC Cancer, 2019 Background The recent implementation of PET with prostate specific membrane antigen (PSMA)-specific radiotracers into the clinical practice has resulted in the significant improvement of accuracy in the detection of prostate carcinoma (PCa).
Heike Endepols +8 more
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Electrochemical radiofluorination using a split-bipolar electrode
Journal of Fluorine Chemistryidentifier:oai:t2r2.star.titech.ac.jp ...
Tomoyuki Kurioka +8 more
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Synthesis and evaluation of 18F-labeled inhibitors for targeting mutant isocitrate dehydrogenase 1 (mIDH1) [PDF]
, 2023 PET is a fundamental imaging method used for in vivo visualization of physiological and pathophysiological processes on the molecular level. This technique relies on radiotracers, which consist of a pharmacophore addressing the biological target of ...
Cologni, Roberta
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