Results 81 to 90 of about 2,508 (203)
Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF
Organic Letters, 2016 A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [18F]KF is described. This method is fast, uses commercially available reagents, and is compatible with both electron-rich and electron-deficient arene substrates. This method has been applied to the manual synthesis of a variety of clinically relevant radiotracers ...
Makaravage, Katarina J. +4 more
openaire +2 more sources
Aryl trimethylammonium trifluoromethanesulfonates as precursors to aryl [18F]fluorides [PDF]
, 1989 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90143/1/2580260109_ftp ...
Angelini +6 more
core +1 more source
Nucleophilic Synthesis of 6-l-[18F]FDOPA. Is Copper-Mediated Radiofluorination the Answer?
Molecules, 2020 Positron emission tomography employing 6-l-[18F]fluoro-3,4-dihydroxyphenylalanine (6-l-[18F]FDOPA) is currently a highly relevant clinical tool for detection of gliomas, neuroendocrine tumors and evaluation of Parkinson’s disease progression.
Raisa N. Krasikova
doaj +1 more source
Introduction of Fluorine and Fluorine-Containing Functional Groups [PDF]
, 2013 Over the past decade, the most significant, conceptual advances in the field of fluorination were enabled most prominently by organo- and transition-metal catalysis.
Liang, Theresa +2 more
core +1 more source
Pioneering Metal‐Free Late‐Stage C−H Functionalization Using Acridinium Salt Photocatalysis
Chemistry – A European Journal, Volume 30, Issue 67, December 2, 2024.Organic dyes are powerful photocatalysts in organic transformations due to their availability, adaptable absorption, and diverse structures. Acridinium‐based organo‐photocatalysts, notable for visible light responsiveness, efficiently functionalize inert C−H bonds under mild conditions without transition metals.
Shyamal Kanti Bera, Andrea Porcheddu
wiley +1 more source
Fully automated synthesis of [18F]T807, a PET tau tracer for Alzheimer’s disease [PDF]
, 2015 The authentic standard T807 and its nitro-precursor T807P as well as t-Boc-protected T807P precursor for radiolabeling were synthesized from (4-bromophenyl)boronic acid, 3-bromo-4-nitropyridine and 3-bromo-6-nitropyridine with overall chemical yield 27 ...
Gao, Mingzhang +2 more
core +1 more source
Molecules, 2012 The semisynthetic oripavine derivative phenethyl orvinol (PEO), a full agonist at opioid receptors (OR), is an attractive structural motif for developing 18F-labeled PET tracers with a high degree of sensitivity for competition between endogenous and ...
Gjermund Henriksen, János Marton
doaj +1 more source
Chemistry – A European Journal, Volume 30, Issue 55, October 1, 2024.A method was rationally optimized to minimize deleterious protodeboronation side‐product in Cu‐mediated 19F‐ and 18F‐fluorination of arylboronic acids. Fluoride anion is activated through a hydrogen bond donor (HBD) effect under ligandless conditions featuring a new copper salt, Cu(ONf)2.
Jingkai Sun +3 more
wiley +1 more source
Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin
Molecules, 2019 There is an unmet need for late-stage 18F-fluorination strategies to label molecules with a wide range of relevant functionalities to medicinal chemistry, in particular (hetero)arenes, aiming to obtain unique in vivo information on the pharmacokinetics ...
Gonçalo S. Clemente +3 more
doaj +1 more source
[18F]DPA-714 as a biomarker for positron emission tomography imaging of rheumatoid arthritis in an animal model. [PDF]
, 2014 International audienceINTRODUCTION: Rheumatoid arthritis (RA) is a chronic disease, affecting 0.5-1% of adults in industrialized countries, in which systemic inflammation and synovitis drive joint destruction.
Bernards, Nicholas +3 more
core +4 more sources