Results 41 to 50 of about 1,169 (122)

Synthesis of a Potent Aminopyridine-Based nNOS-Inhibitor by Two Recent No-Carrier-Added 18F-Labelling Methods

Molecules, 2016
Nitric oxide (NO), an important multifunctional signaling molecule, is produced by three isoforms of NO-synthase (NOS) and has been associated with neurodegenerative disorders.
Christian Drerup, Johannes Ermert, Heinz H. Coenen   +2 more
doaj   +1 more source

Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) ¹⁸F-Radiopharmaceuticals

Pharmaceuticals, 2021
The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of 18F-radiopharmaceuticals for medical imaging.
Lexi Gower-Fry, Travis Kronemann, Andreas Dorian, Yinglan Pu, Carolin Jaworski, Carmen Wängler, Peter Bartenstein, Leonie Beyer, Simon Lindner, Klaus Jurkschat, Björn Wängler, Justin J. Bailey, Ralf Schirrmacher   +12 more
doaj   +1 more source

Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent

EJNMMI Research, 2022
Purpose Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer.
Claudia Rose Fraser, Javier Ajenjo, Mathew Veal, Gemma Marie Dias, Chung Chan, Edward O’Neill, Gianluca Destro, Doreen Lau, Anna Pacelli, Veronique Gouverneur, Rebekka Hueting, Bart Cornelissen   +11 more
doaj   +1 more source

Isotopic Radiolabeling of the Antiretroviral Drug [¹⁸F]Dolutegravir for Pharmacokinetic PET Imaging

Pharmaceuticals, 2022
Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegravir (DTG) is one
Marion Tisseraud, Sébastien Goutal, Thomas Bonasera, Maud Goislard, Delphine Desjardins, Roger Le Grand, Chris M. Parry, Nicolas Tournier, Bertrand Kuhnast, Fabien Caillé   +9 more
doaj   +1 more source

Radiofluorination of an Anionic, Azide-Functionalized Teroligomer by Copper-Catalyzed Azide-Alkyne Cycloaddition

Nanomaterials, 2023
This study describes the synthesis, radiofluorination and purification of an anionic amphiphilic teroligomer developed as a stabilizer for siRNA-loaded calcium phosphate nanoparticles (CaP-NPs).
Barbara Wenzel, Maximilian Schmid, Rodrigo Teodoro, Rareş-Petru Moldovan, Thu Hang Lai, Franziska Mitrach, Klaus Kopka, Björn Fischer, Michaela Schulz-Siegmund, Peter Brust, Michael C. Hacker   +10 more
doaj   +1 more source

Synthesis and Radiosynthesis of Prospective 2-Nitroimidazole Hypoxia­ PET Tracers via Thiazolidine Ligation with 5-Fluorodeoxyribose (FDR)

SynOpen, 2017
The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation.
M. Musolino, S. Dall’Angelo, M. Zanda
doaj   +1 more source

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco, Matthew Tredwell, Peter J. J. A. Buijnsters, Rhys Salter, Véronique Gouverneur   +13 more
wiley   +2 more sources

A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [¹⁸F]fluoride: Will [¹⁸F]AlF Replace ⁶⁸Ga for Metal Chelate Labeling?

Molecules, 2019
Due to its ideal physical properties, fluorine-18 turns out to be a key radionuclide for positron emission tomography (PET) imaging, for both preclinical and clinical applications.
Cyril Fersing, Ahlem Bouhlel, Christophe Cantelli, Philippe Garrigue, Vincent Lisowski, Benjamin Guillet   +5 more
doaj   +1 more source

Synthesis and Structural Study of Iodonium Ylides Derived From 2‐Iodosylbenzenesulfonic Acid: Reagents for Preparation of Annulated Thiazoles

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
New ylides of two different types were prepared by reaction of 2‐iodosylbenzenesulfonic acid with the corresponding 1,3‐cyclohexanediones under acidic or basic conditions. These compounds have a typical for iodonium ylides structure with the CIC angles 94.18° –97.25° and the IC bond distances between 2.08 and 2.13 Å.
Dmitry M. Noskov, Matvey K. Shurikov, Irina A. Mironova, Natalia S. Soldatova, Akira Yoshimura, Akio Saito, Mekhman S. Yusubov, Viкtor V. Zhdankin   +7 more
wiley   +1 more source

[¹⁸F]-Radiolabelled Nanoplatforms: A Critical Review of Their Intrinsic Characteristics, Radiolabelling Methods, and Purification Techniques

Molecules
A wide range of nano-objects is found in many applications of our everyday life. Recognition of their peculiar properties and ease of functionalization has prompted their engineering into multifunctional platforms that are supposed to afford efficient ...
Maëlle Deleuziere, Éric Benoist, Isabelle Quelven, Emmanuel Gras, Catherine Amiens   +4 more
doaj   +1 more source