Results 11 to 20 of about 1,169 (122)

Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes

Molecules, 2013
The polymer supported phosphazene bases PS-P2tBu and the novel PS-P2PEG allowed for efficient extraction of [18F]F− from proton irradiated [18O]H2O and subsequent radiofluorination of a broad range of substrates directly on the resin.
Fedor Zhuravlev
exaly   +3 more sources

Fully Automated Production of (((S)-1-Carboxy-5-(6-([¹⁸F]fluoro)-2-methoxynicotinamido)pentyl)carbamoyl)-l-glutamic Acid ([¹⁸F]JK-PSMA-7) [PDF]

Pharmaceuticals
Background: The radiotracer [18F]JK-PSMA-7, a prostate cancer imaging agent for positron emission tomography (PET), was previously synthesized by indirect radiofluorination using an 18F-labeled active ester as a prosthetic group, which had to be isolated
Philipp Krapf, Thomas Wicher, Boris D. Zlatopolskiy, Johannes Ermert, Bernd Neumaier   +4 more
doaj   +2 more sources

A simplified, robust protocol for [18F]fluoride elution under mild conditions to enhance late-stage aromatic radiofluorinations [PDF]

Scientific Reports
Direct radiofluorination of base-sensitive PET precursors is challenging due to the harsh reaction conditions of traditional fluorine-18 radiochemistry. In particular, the presence of inorganic bases with a relatively high conjugate pK a (e.g. K2CO3) and
Stefan Milton, Alexandros Pappas, Niki Constantinou, Staffan Holmin, Jeroen A. C. M. Goos   +4 more
doaj   +2 more sources

Lewis Acid-Facilitated Radiofluorination of MN3PU: A LRRK2 Radiotracer

Molecules, 2020
Background: Temperature-sensitive radiopharmaceutical precursors require lower reaction temperatures (
Paul Schaffer, Ralf Schirrmacher, Noeen Malik   +2 more
exaly   +3 more sources

Simple and Efficient Synthesis of N-Succinimidyl-4-[¹⁸F]fluorobenzoate ([¹⁸F]SFB)—An Important Intermediate for the Introduction of Fluorine-18 into Complex Bioactive Compounds [PDF]

Pharmaceuticals
Background: N-succinimidyl-[18F]fluorobenzoate ([18F]SFB) is commonly prepared through a three-step procedure starting from [18F]fluoride ion. A number of methods for the single-step radiosynthesis of [18F]SFB have been introduced recently, including the
Viktoriya V. Orlovskaya, Olga S. Fedorova, Nikolai B. Viktorov, Raisa N. Krasikova   +3 more
doaj   +2 more sources

Fluorinated Derivatives of AG-881 for Positron Emission Tomography Detection of Mutated Isocitrate Dehydrogenase 1 [PDF]

Pharmaceuticals
Background/Objectives: Since 2016, the mutation of isocitrate dehydrogenase 1 (mIDH1) enzymes has become a major molecular marker for glioma classification and diagnosis. Moreover, the recent success of the INDIGO clinical trial on AG-881 (vorasidenib®),
Thu Hang Lai, Sladjana Dukić-Stefanović, Winnie Deuther-Conrad, Aurélie Maisonial-Besset, Rodrigo Teodoro, Magali Toussaint, Barbara Wenzel   +6 more
doaj   +2 more sources

Automation of Copper-Mediated ¹⁸F-Fluorination of Aryl Pinacol Boronates Using 4-Dimethylaminopyridinium Triflate [PDF]

Molecules
Currently, the copper-mediated radiofluorination of aryl pinacol boronates (arylBPin) using the commercially available, air-stable Cu(OTf)2Py4 catalyst is one of the most efficient synthesis approaches, greatly facilitating access to a range of ...
Mikhail A. Nadporojskii, Viktoriya V. Orlovskaya, Olga S. Fedorova, Dmitry S. Sysoev, Raisa N. Krasikova   +4 more
doaj   +2 more sources

The hydrogenation side-reaction in copper-mediated radiofluorination [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Copper-mediated radiofluorination (CMRF) is a breakthrough in 18F-radiochemistry, enabling 18F incorporation into molecules even at electron-rich aromatic positions. In recent years, several improved protocols have been reported to advance the
Sarandeep Kaur, Barbara Wenzel, Ramona Oehme, Claudia Wiesner, Klaus Kopka, Rareş-Petru Moldovan   +5 more
doaj   +2 more sources

Expanding tracer space for positron emission tomography with high molar activity 18F-labeled α,α-difluoromethylalkanes [PDF]

Nature Communications
Positron emission tomography (PET) is an advanced biomedical imaging modality that relies on well-designed radiotracers to report on specific protein targets and processes occurring in living animals and humans. Cyclotron-produced short-lived fluorine-18
Qunchao Zhao, Sanjay Telu, Shuiyu Lu, Victor W. Pike   +3 more
doaj   +2 more sources

Aryl and Alkyl Radiotrifluoromethylation via Metallaphotoredox-Mediated Radical Cross-Coupling. [PDF]

Angew Chem Int Ed Engl
The metallaphotoredox‐mediated radiotrifluoromethylation of arenes and alkanes is described. The operationally simple protocols make use of substrates bearing thianthrenium salts (TT) or N‐hydroxyphthalimide (NHPI) esters and CF218FI. The reaction proceeds through a Ru‐mediated radical formation followed by a Cu‐mediated radical cross‐coupling step and
Veth L, Windhorst AD, Vugts DJ.
europepmc   +3 more sources