Results 11 to 20 of about 2,508 (203)

Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes [PDF]

Molecules, 2013
The polymer supported phosphazene bases PS-P2tBu and the novel PS-P2PEG allowed for efficient extraction of [18F]F− from proton irradiated [18O]H2O and subsequent radiofluorination of a broad range of substrates directly on the resin.
Bente Mathiessen, Fedor Zhuravlev
doaj   +4 more sources

Aryl and Alkyl Radiotrifluoromethylation via Metallaphotoredox-Mediated Radical Cross-Coupling. [PDF]

Angew Chem Int Ed Engl
The metallaphotoredox‐mediated radiotrifluoromethylation of arenes and alkanes is described. The operationally simple protocols make use of substrates bearing thianthrenium salts (TT) or N‐hydroxyphthalimide (NHPI) esters and CF218FI. The reaction proceeds through a Ru‐mediated radical formation followed by a Cu‐mediated radical cross‐coupling step and
Veth L, Windhorst AD, Vugts DJ.
europepmc   +2 more sources

Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the prosthetic group (PG) [18F]SFB
Herlinde Dierick, Laurent Navarro, Hannelore Ceuppens, Thomas Ertveldt, Ana Rita Pombo Antunes, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot, Matthias D’Huyvetter, Tony Lahoutte, Vicky Caveliers, Jessica Bridoux   +11 more
doaj   +2 more sources

Automated radiofluorination of HER2 single domain antibody: the road towards the clinical translation of [18F]FB-HER2 sdAb [PDF]

EJNMMI Radiopharmacy and Chemistry
Background With the next generation of Human Epidermal Growth Factor Receptor 2 (HER2) -targeting therapies, such as antibody–drug conjugates, showing benefit in “HER2 low” and even “HER2 ultralow” patients, the need for novel methods to quantify HER2 ...
Herlinde Dierick, Laurent Navarro, Sonja Van den Block, Jelena Saliën, Tony Lahoutte, Vicky Caveliers, Jessica Bridoux   +6 more
doaj   +2 more sources

25 Years of "Loop" Radiochemistry for PET Imaging. [PDF]

J Labelled Comp Radiopharm
While conventional methods to 11C‐ and 18F‐labelled radiopharmaceuticals utilize a vial‐based approach, in the past quarter‐century, a modern, efficient, and cleaner “loop method” has been developed. The radiochemical diversity of reactions synthesized by the loop method are shown.
Murrell E, Khan S, Vasdev N.
europepmc   +2 more sources

Radiosynthesis of 5-[¹⁸F]Fluoro-1,2,3-triazoles through Aqueous Iodine–[¹⁸F]Fluorine Exchange Reaction

Molecules, 2021
In this report, a simple and efficient process to achieve fluorine-18-labeled 1,2,3-triazole is reported. The heteroaromatic radiofluorination was successfully achieved through an iodine–fluorine-18 exchange in an aqueous medium requiring only trace ...
Xiang Zhang, Falguni Basuli, Sameh Abdelwahed, Tadhg Begley, Rolf Swenson   +4 more
doaj   +1 more source

[18F]Tosyl fluoride as a versatile [18F]fluoride source for the preparation of 18F-labeled radiopharmaceuticals

Scientific Reports, 2023
Positron emission tomography (PET) is an in vivo imaging technology that utilizes positron-emitting radioisotope-labeled compounds as PET radiotracers that are commonly used in clinic and in various research areas, including oncology, cardiology, and ...
Dong Zhou, Wenhua Chu, Jinbin Xu, Sally Schwarz, John A. Katzenellenbogen   +4 more
doaj   +1 more source

Mild, Organo-Catalysed Borono-Deamination as a Key to Late-Stage Pharmaceutical Precursors and 18F-Labelled Radiotracers

Frontiers in Chemistry, 2022
A tris(pentafluorophenyl)borane catalysed method for the synthesis of boronic acid esters from aromatic amines in yields of up to 93% was devised.
Raúl M. Pérez-García, Patrick J. Riss, Patrick J. Riss, Patrick J. Riss, Patrick J. Riss   +4 more
doaj   +1 more source

Triflyl [¹⁸F]Fluoride as a Solution for Base-Sensitive Late-Stage Nucleophilic Aromatic ¹⁸F-Fluorination Reactions. [PDF]

Chemistry
Here, we present the late‐stage nucleophilic 18F‐fluorination of (hetero)aryls under low‐base conditions using triflyl [18F]fluoride. This method avoids the application of base and cryptand and enabled the efficient radiolabeling of a broad scope of (hetero)arenes and the successful production of clinical doses of [18F]mFBG, [18F]SynVesT‐1 and [18F ...
Haveman LYF, de Kruijff AMT, van Eeden SPP, Windhorst AD, Vugts DJ.   +4 more
europepmc   +2 more sources

Strained Ammonium Precursors for Radiofluorinations

ChemistryOpen, 2022
AbstractThe increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of novel and versatile techniques to introduce fluorine‐18, especially for the radiolabelling of biologically or pharmacologically active molecules.
Reissig, F., Mamat, C.
openaire   +4 more sources