Results 41 to 50 of about 3,257,828 (382)

Fluorination of silyl prosthetic groups by fluorine mediated silyl ether linker cleavage: a concept study with conditions applicable in radiofluorination

open access: yesEJNMMI Radiopharmacy and Chemistry, 2022
Background Positron emission tomography (PET) is a powerful tool in medical imaging, especially in combination with the PET radionuclide fluorine-18 that possesses optimal characteristics.
Carsten Sven Kramer   +3 more
doaj   +1 more source

Towards the development of new subtype-specific muscarinic receptor radiopharmaceuticals-radiosynthesis and ex vivo biodistribution of [18F] 3-(4-(2-(2-(2-fluoroethoxy) ethoxy) ethylthio)-1, 2, 5-thiadiazol-3-yl)-1-methyl-1, 2, 5, 6-tetrahydropyridine [PDF]

open access: yes, 2010
Muscarinic receptors have been implicated in neurological disorders including Alzheimer’s disease, Parkinson’s disease, and schizophrenia. Nineteen derivatives of thiadiazolyltetrahydropyridine (TZTP), a core that has previously shown high affinities ...
Houle, Sylvain   +6 more
core   +1 more source

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis [PDF]

open access: yes, 2012
There is growing evidence of activated microglia and inflammatory processes in the cerebral cortex in amyotrophic lateral sclerosis (ALS). Activated microglia is characterized by increased expression of the 18 kDa translocator protein (TSPO) in the brain
Arlicot, Nicolas   +14 more
core   +2 more sources

Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist.

open access: yesBritish Journal of Radiology, 2016
Squamous cell carcinoma is the most common malignant tumour of the head and neck. The initial TNM staging, the evaluation of the tumour response during treatment, and the long-term surveillance are crucial moments in the approach to head and neck ...
J. Cacicedo   +12 more
semanticscholar   +1 more source

Development of novel fluorine-18 labeled PET radioligands for monoamine oxidase B (MAO-B) [PDF]

open access: yes, 2013
Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selectiv e and irreversible MAO-B inhibitors such as L -deprenyl and rasagiline are clinically used for the t reatment of ...
Nag, Sangram
core   +2 more sources

2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET—Synthesis, Triage, and Radiolabeling

open access: yesMolecules, 2018
Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation.
Michelle Y. Cortes-Salva   +8 more
doaj   +1 more source

18FDG production in a PET imaging using a proton flux produced by D-D fusion reaction

open access: yesBasic & Clinical Cancer Research, 2022
Fluorine 18-deoxyglucose (18FDG) is often used in Positron Emission Tomography (PET). PET imaging is one of the useful tool which is used to cancer detection and management. PET growth is limited due to problems that depend on the production of Fluorine-
Nasrin Niknam   +2 more
doaj  

Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging

open access: yesMolecules, 2020
Recent progress realized in the development of optical imaging (OPI) probes and devices has made this technique more and more affordable for imaging studies and fluorescence-guided surgery procedures.
Maxime Munch   +2 more
doaj   +1 more source

Optimization of Automated Solid Phase Extraction-based Synthesis of [18F]Fluorocholine

open access: yesKorean Journal of Clinical Laboratory Science, 2023
[18F]Fluorocholine is a radiopharmaceutical used non-invasively in positron emission tomography to diagnose parathyroid adenoma, prostate cancer, and hepatocellular carcinoma by evaluating the choline metabolism. In this study, a radiolabeling method for
Jun Young PARK   +2 more
doaj   +1 more source

Comparative Wear and Friction Analysis of Sliding Surface Materials for Hydrostatic Bearing under Oil Supply Failure Conditions

open access: yesAdvanced Engineering Materials, EarlyView.
Hydrostatic bearings excel in high‐precision applications, but their performance hinges on a continuous external supply. This study evaluates various material combinations for sliding surfaces to mitigate damage during supply failures or misalignment and to discover the most effective materials identified for enhancing the reliability and efficiency of
Michal Michalec   +6 more
wiley   +1 more source

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