Results 1 to 10 of about 152,257 (144)
Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models [PDF]
EJNMMI Research, 2017 Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient.
Outi Keinänen +9 more
doaj +5 more sources
Exploring the radiochemistry of PARP inhibitors: a new era in therapy and imaging [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as a promising class of therapeutics, particularly in the treatment of cancers with defective DNA repair mechanisms, such as those with breast cancer genes (BRCA) mutations.
Gianluca Destro +4 more
doaj +3 more sources
SN Applied Sciences, 2020 A plethora of cyclotron options have been developed to fulfil the demands of nuclear medicine industries in PET and SPECT radioisotopes. As a remote site, the difficulties of transporting fluorine 18 radiopharmaceuticals for PET examinations were ...
Andreas Fesas +2 more
doaj +3 more sources
ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes [PDF]
EJNMMI Research, 2016 BackgroundAutomated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioactivity and an efficient workflow ...
A. Dooraghi +4 more
semanticscholar +4 more sources
Physics in Medicine & Biology, 2018 In this work we compare spatially variant radioisotope-specific point spread functions (PSFs) derived from published positron range data with measured data using a high resolution research tomograph (HRRT). Spatially variant PSFs were measured on a HRRT for fluorine-18, carbon-11 and gallium-68 using an array of printed point sources.
Jose M Anton-Rodriguez +7 more
openaire +4 more sources
Fluorine-18 incorporation and radiometal coordination in macropa ligands for PET imaging and targeted alpha therapy. [PDF]
Chem Commun (Camb)The development of theranostic agents for radiopharmaceuticals based on therapeutic alpha emitters marks an important clinical need. We describe a strategy for the development of theranostic agents of this type via the functionalization of the ligand ...
Kanagasundaram T +5 more
europepmc +2 more sources
Folate-Based Radiotracers for PET Imaging—Update and Perspectives
Molecules, 2013 The folate receptor (FR) is expressed in many tumor types, among those ovarian and lung cancer. Due to the high FR affinity of folic acid, it has been used for targeting of FR-positive tumors, allowing specific delivery of attached probes to the ...
Cristina Müller
doaj +2 more sources
Sortase-Mediated Site-Specific Conjugation to Prepare Fluorine-18-Labeled Nanobodies. [PDF]
Bioconjug ChemSingle-domain antibodies, or nanobodies (Nbs), are promising biomolecules for use in molecular imaging due to their excellent affinity, specificity, and fast clearance from the blood.
Basuli F +9 more
europepmc +2 more sources
Diagnostics, 2014 Quantitative and qualitative characterization of fluorinated molecules represents an important task. Fluorine-based medicinal chemistry is a fast-growing research area due to the positive impact of fluorine in drug discovery, and clinical and molecular ...
Farid Menaa +2 more
doaj +2 more sources