Radiolabeling Strategies for Tumor-Targeting Proteinaceous Drugs
Molecules, 2014 Owing to their large size proteinaceous drugs offer higher operative information content compared to the small molecules that correspond to the traditional understanding of druglikeness.
Grant Sugiura +4 more
doaj +1 more source
Development of PDT/PET theranostics: synthesis and biological evaluation of an ¹⁸F-radiolabeled water soluble porphyrin [PDF]
, 2015 Synthesis of the first water-soluble porphyrin radiolabeled with fluorine-18 is described: a new molecular theranostic agent which integrates the therapeutic selectivity of photodynamic therapy (PDT) with the imaging efficacy of positron emission ...
Allott, Louis +7 more
core +1 more source
World Journal of Nuclear Medicine, 2015 Dose calibrator linearity testing is indispensable for evaluating the capacity of this equipment in measuring radioisotope activities at different magnitudes, a fundamental aspect of the daily routine of a nuclear medicine department, and with an impact ...
José Willegaignon +7 more
doaj +1 more source
Folate-Based Radiotracers for PET Imaging—Update and Perspectives
Molecules, 2013 The folate receptor (FR) is expressed in many tumor types, among those ovarian and lung cancer. Due to the high FR affinity of folic acid, it has been used for targeting of FR-positive tumors, allowing specific delivery of attached probes to the ...
Cristina Müller
doaj +1 more source
Comparison of the efficacy of biodegradable and non-biodegradable scintillation liquids on the counting of tritium- and [14C]-labeled compounds [PDF]
, 2003 The widespread use of ³H and 14C in research has generated a large volume of waste mixed with scintillation liquid, requiring an effective control and appropriate storage of liquid radioactive waste.
Godinho, Rosely Oliveira +2 more
core +3 more sources
Stable BF2 Boracycles as Versatile Reagents for Selective Ortho C–H Functionalization
Angewandte Chemie, Volume 138, Issue 8, 16 February 2026.We report a robust, metal‐free and scalable synthesis of stable BF2 boracycles via directed ortho CH borylation, delivering isolable, shelf‐stable reagents without chromatographic purification. These BF2 boracycles exhibit unique and tunable reactivity, enabling highly selective ipso‐functionalization across a broad range of transformations.
Ganesh H. Shinde +11 more
wiley +2 more sources
Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management. [PDF]
ChembiochemRadiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Shaikh MS +7 more
europepmc +2 more sources
Trace Analysis of Marine Organisms: A Comparison of Activation Analysis and Conventional Methods [PDF]
, 1959 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109766/1/lno1959440398 ...
Fukai, Rinnosuke, Meinke, W. W.
core +1 more source
Frontiers in PharmacologyObjectiveTo optimize the automated radiosynthesis of the purinergic ion channel receptor 7 (P2X7R) imaging agent 18F-JNJ64413739 and evaluate its potential for brain imaging in osteoporotic model rats.MethodsA more electron-deficient nitropyridine was ...
Yingtong Lu +9 more
doaj +1 more source
Why are we failing to implement imaging studies with radiolabelled new molecular entities in early oncology drug development? [PDF]
, 2014 In early drug development advanced imaging techniques can help with progressing new molecular entities (NME) to subsequent phases of drug development and thus reduce attrition.
Lahn, M +3 more
core +3 more sources