Results 101 to 110 of about 15,492 (288)

Analysis of Single Particles of Amyloid Beta and α‐Synuclein With Seeded Amplification for the Diagnosis of Alzheimer's and Parkinson's Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala, Marlene Pils, Oliver Bannach, Gültekin Tamgüney, Detlev Riesner   +4 more
wiley   +1 more source

Fluorochrome-labeled Tyramides: Use in Immunocytochemistry and Fluorescence In Situ Hybridization [PDF]

, 1997
R.P.M. van Gijlswijk, Henry Zijlmans, J. Wiegant, Mark N. Bobrow, Thomas J. Erickson, Karl Adler, Hans J. Tanke, Anton K. Raap   +7 more
openalex   +1 more source

Monocyte maturation pattern by flow cytometry expression of CD64, CD300e, and CD14 correlates to presence of myeloid neoplasm and helps identify blast equivalents in the setting of monocytic neoplasm

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract CD300e is a marker of mature monocytes in flow cytometry; however, there is limited detailed information on staining patterns in conjunction with other monocyte markers. We evaluated the flow cytometric staining patterns of CD64, CD14, and CD300e in 12 negative and 33 positive peripheral blood specimens and 16 negative and 56 positive bone ...
Jenny Zhang, Jacob Kaplan, Elizabeth Courville   +2 more
wiley   +1 more source

Aging Reshapes γ/δ T-Cell Immunity Through a Type I Interferon-Foxo1 Axis. [PDF]

Aging Cell
Aging reshapes the peripheral γ/δ T‐cell compartment by promoting the expansion and enhanced IL‐17–driven activity of innate‐like γ/δ T cells in secondary lymphoid organs. This remodeling is controlled by type I interferon–dependent downregulation of Foxo1, linking aging to heightened pro‐inflammatory γ/δ T‐cell responses.
Durand A, Porte S, Xing E, Wu C, Le Bon A, Auffray C, Lucas B, Martin B.   +7 more
europepmc   +2 more sources

In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors [PDF]

, 2002
Jerzy Grabarek, Zbigniew Darżynkiewicz
openalex   +1 more source

Antigen-specific staining of EV markers with fluorochrome-conjugated antibodies v1 [PDF]

, 2020
Aizea Morales‐Kastresana, Joshua A Welsh, Jennifer Jones   +2 more
openalex   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Analysis of Hepatitis C Virus Superinfection Exclusion by Using Novel Fluorochrome Gene-Tagged Viral Genomes [PDF]

, 2007
Torsten Schaller, Nicole Appel, George Koutsoudakis, Stephanie Kallis, Volker Lohmann, Thomas Pietschmann, Ralf Bartenschlager   +6 more
openalex   +1 more source

A de novo strategy to develop NIR precipitating fluorochrome for long-term in situ cell membrane bioimaging

, 2021
Ke Li, Yifan Lyu, Yan Huang, Shuai Xu, Hong‐Wen Liu, Lanlan Chen, Tian‐Bing Ren, Mengyi Xiong, Shuangyan Huan, Lin Yuan, Xiaobing Zhang, Weihong Tan   +11 more
openalex   +2 more sources

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source