Results 91 to 100 of about 174,614 (242)

Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects

Clinical Pharmacology &Therapeutics, EarlyView.
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen, Eugène T.P. Verwiel, Maaike van der Lee, Jesse J. Swen, Marcel Santoso, Leiah J. Brigitha, Rick Admiraal, Bastiaan B.J. Tops, Alwin D.R. Huitema, Patrick Kemmeren, Jayne Y. Hehir‐Kwa, Lidwien M. Hanff, Meta H.M. Diekstra   +12 more
wiley   +1 more source

Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver. [PDF]

, 2007
We administered an adenoviral vector, Onyx-015, into the hepatic artery of patients with metastatic colorectal cancer involving the liver. Thirty-five patients enrolled in this multi-institutional phase I/II trial received up to eight arterial infusions ...
Au, T, Kirn, D, Korn, WM, Reid, TR, Sze, D, Thorne, S   +5 more
core  

Magnetic Layered Double Hydroxide Nanocomposites: Synthesis, Catalytic Performances, Environmental and Biological Applications

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This review involves a comprehensive study on the diverse applications of the magnetic layered double hydroxides (LDHs) including their catalytic performances, as well as, environmental and biological functions. Moreover, different strategies utilized for the synthesis of LDH‐based composites are described.
Mohammad Mavvaji, Ahmed M. Senan, Senem Akkoc   +2 more
wiley   +1 more source

Black Garlic: Production Process, Bioactive Compounds, and Health Effects

Food Chemistry International, EarlyView.
Black garlic, produced under controlled temperature and humidity, undergoes biochemical transformations that enhance its antioxidant capacity, bioactive compounds, and unique flavor profile. This review highlights its production process, health benefits, and functional food potential based on scientific evidence.
Hatice Kubra Sasmaz, Turkan Uzlasir, Serkan Selli, Hasim Kelebek   +3 more
wiley   +1 more source

Adjuvant Intensity Modulated Radiation Therapy With a Pedicled Flap Reconstruction in Oral Cavity Squamous Cell Carcinomas: Implications on Target Delineation

Head &Neck, EarlyView.
ABSTRACT Objectives To address controversies regarding target volume delineation for adjuvant intensity‐modulated radiation therapy for oral cavity squamous cell carcinoma with pedicled flap reconstruction and elective nodal irradiation (ENI). Materials and Methods During target volume delineation, the primary tumor bed was the pre‐surgical gross tumor
Sarbani Ghosh Laskar, Shwetabh Sinha, Pritha Roy, Rabi Das, Shivakumar Thigarajan, Anuj Kumar, Samarpita Mohanty, Ashwini Budrukkar, Monali Swain, Devendra Chaukar, Gouri Pantvaidya, Anuja Deshmukh, Prathamesh Pai, Deepa Nair, Sudhir Nair, Poonam Joshi, Rathan Shetty, Arjun Singh, Vidisha Tuljapurkar, Richa Vaish, Pankaj Chaturvedi   +20 more
wiley   +1 more source

Treatment Outcomes of Squamous Cell Carcinoma of the Soft Palate and the Prognostic Significance of HPV/p16 Status

Head &Neck, EarlyView.
ABSTRACT Background Squamous cell carcinoma of the soft palate (SCCSP) represents a rare subtype of oropharyngeal cancer. This study aims to evaluate the treatment outcomes of SCCSP and to assess the prognostic significance of HPV status. Methods Patients diagnosed with SCCSP between January 1981 and December 2021 were collected. Survival outcomes were
Meng‐hua Li, Xing Zhang, Feng‐jiao Li, Xian‐lu Gao, Shi‐da Yan, Qiao‐hong Lin, Xi‐yuan Li, Jian Meng, Ying Zhang, Shi‐ting Zhang, Shu‐wei Chen, Ming Song   +11 more
wiley   +1 more source

Sinonasal Intestinal‐Type Adenocarcinoma in the Netherlands: A Nationwide Study (2008–2022)

Head &Neck, EarlyView.
ABSTRACT Background Intestinal‐type adenocarcinoma (ITAC) is a rare sinonasal malignancy with poor survival. By creating a clinical and epidemiological overview of the Dutch ITAC population between 2008 and 2022, this study aims to identify areas for improvement in ITAC management. Methods A systematic query within the Netherlands Cancer Registry (NCR)
Lise J. van de Velde, Gerben E. Breimer, W. F. Julius Scheurleer, Mischa de Ridder, Lot A. Devriese, Weibel W. Braunius, Remco de Bree, Boukje A. C. van Dijk, Johannes A. Rijken   +8 more
wiley   +1 more source

Efficacy of Eribulin Monotherapy in Patients With Unresectable and/or Metastatic Adenoid Cystic Carcinoma Receiving Platinum‐Based Therapy

Head &Neck, EarlyView.
ABSTRACT Background Adenoid cystic carcinoma (ACC) is the second most common and treatment‐resistant salivary gland carcinoma (SGC). Although platinum‐based therapies are effective, the efficacy of eribulin, a microtubule inhibitor with an 18% response rate in a Phase II trial involving recurrent/metastatic SGC, in patients with advanced ACC after ...
Tomomi Sanomachi, Tatsunori Shimoi, Yuki Kojima, Hideaki Takahashi, Motoko Arakaki, Asuka Kawachi, Hitomi Sumiyoshi Okuma, Mai Hoshino, Munehiro Ito, Ayumi Saito, Shosuke Kita, Aiko Maejima, Tadaaki Nishikawa, Kazuki Sudo, Taisuke Mori, Yasuhiro Fujiwara, Kan Yonemori   +16 more
wiley   +1 more source

Recurrence of rectal cancer : a study on patients with rectal cancer referred to Sir Paul Boffa Hospital during 2001-2003 [PDF]

, 2009
Surgery is the mainstay of treatment of rectal cancer. One third of all treatment failures are secondary to local recurrence usually leading to a painful and distressing death.
Brincat, Stephen, Said, Janabel, von Brockdorff, Luisa   +2 more
core  

Body mass index as a predictive factor for efficacy of adjuvant taxane‐based chemotherapy in early‐stage breast cancer patients: A pooled analysis from adjuvant GEICAM Spanish Breast Cancer Group and TRIO Translational Research in Oncology Group studies

International Journal of Cancer, EarlyView.
What's New? Body mass index (BMI) potentially influences outcomes among women with early‐stage breast cancer (EBC). Little is known, however, about relationships between BMI and disease prognosis for different adjuvant taxane‐based chemotherapies. Here, the prognostic effect of BMI on disease recurrence was evaluated among EBC patients treated with ...
José A. García‐Saenz, Gonzalo Spera, Marina Pollán, Begoña Bermejo, Manuel Ruiz‐Borrego, Arlene Chan, Miguel Martín, Ángel Guerrero‐Zotano, Lourdes Calvo, Álvaro Rodríguez‐Lescure, María Marín, Linnea Chap, John Crown, Tadeusz Pienkowski, Valerie Bee, Maribel Casas, Óscar Polonio, Susana Bezares, Dennis Slamon   +18 more
wiley   +1 more source