Results 221 to 230 of about 174,614 (242)

Resistance to 5-Fluorouracil

General Pharmacology: The Vascular System, 1998
1. Primary and secondary resistance to the widely used antimetabolite 5-fluorouracil (5-FU) are common phenomena in cancer chemotherapy. Because 5-FU still remains the agent of choice in the treatment of, for example, colorectal cancer, circumvention of resistance is of vital importance. 2.
Günther G. Steger, Robert M. Mader, Markus Müller   +2 more
openaire   +2 more sources

Thymidylate Synthase and Fluorouracil

1988
A knowledge of the catalytic mechanism of thymidylate synthase (TS), and its inhibition by 5-fluorodeoxyuridylate (FdUMP) was instrumental in developing the FUra-CF combination for cancer chemotherapy. The generation of the ideas which led to the current combination cleary demonstrates the importance of a fundamental knowledge of the interactions of ...
Daniel V. Santi, Kathryn M. Ivanetich
openaire   +3 more sources

Leucovorin and fluorouracil vs levamisole and fluorouracil as adjuvant chemotherapy in rectal cancer

Oncology Reports, 2004
The aim of this study was to evaluate the effectiveness of 6-month therapy with leucovorin (LV) + 5-fluorouracil (5-FU) vs 12 months of therapy with levamisole (LVZ) + 5-FU, as adjuvant chemotherapy in patients with completely resected Dukes' stage B2 or C rectal cancer.
George C. Zografos, K. Gennatas, Panayiotis Gouveris, G Karatzas, K Fotiadis, Gregory Kouraklis, M Safioleas, D Voros, M Paraskevaidis, M Balafouta, J. Vasiliou, Christos Kosmas, Skopelitis H, Efstathios Papalambros, G. Papastratis, M Zacharakis, E Felekouras, A. Dimitrakopoulos, N. Tsavaris   +18 more
openaire   +3 more sources

Women at a Disadvantage in Fluorouracil Treatment

JAMA Oncology, 2016
International ...
Ciccolini, Joseph, Milano, Gérard
openaire   +4 more sources

Topical Fluorouracil in Vitiligo

Archives of Dermatology, 1985
To the Editor.— I was interested to read of the effect of 5-fluorouracil cream in the treatment of vitiligo as reported from Japan by Tsuji and Hamada. 1 They found that while fluorouracil alone had no effect, its use following epidermal abrasion resulted in repigmentation in the majority of patients.
openaire   +3 more sources

5-Fluorouracil for glaucoma surgery

Cochrane Database of Systematic Reviews, 2014
Trabeculectomy is performed as a treatment for many types of glaucoma in an attempt to lower the intraocular pressure. The surgery involves creating a channel through the sclera, through which intraocular fluid can leave the eye. If scar tissue blocks the exit of the surgically created channel, intraocular pressure rises and the operation fails ...
Catey Bunce, Mark R Wilkins, Elspeth Green, Richard Wormald   +3 more
openaire   +3 more sources

Levofolinate and fluorouracil combination therapy.

Folia Pharmacologica Japonica, 2001
Levofolinate and fluorouracil regimen (l-leucovorin and 5 fluorouracil regimen) is a biochemical modulation of 5 fluorouracil (5FU) by leucovorin (LV). In the USA and Europe d,l-LV and 5FU regimen is frequently administered for colorectal cancer treatment and recognized as the standard regimen.
Shigemi Takeuchi, Minoru Murakami
openaire   +2 more sources

Treatment of Keratoacanthomas With Intralesional Fluorouracil

Archives of Dermatology, 1978
Fourteen patients with 26 keratoacanthomas (KA) were treated weekly with intralesional injections of fluorouracil. Twenty-five lesions cleared in an average of three weeks (range, two to eight weeks) after an average of 2.8 injections. One KA failed to respond after five weekly injections and was excised.
Richard B. Odom, Detlef K. Goette
openaire   +3 more sources

5-Fluorouracil and Derivatives in Cancer Chemotherapy: Determination of 5-Fluorouracil in Blood

Journal of Pharmaceutical Sciences, 1972
The current work describes a dialysis technique which separates 5-fluorouracil from interfering blood components and allows for subsequent GC determinations. The parameters affecting the dialysis and GC are presented. The results indicate that 5-fluorouracil is present in the free and bound states in blood, and the method is capable of distinguishing ...
J.L. Sutter, John J. Windheuser, E. Auen
openaire   +3 more sources

5-Fluorouracil and dihydropyrimidine dehydrogenase

International Journal of Clinical Oncology, 2003
Dihydropyrimidine dehydrogenase (DPD) is a rate-limiting enzyme of (fluorinated) pyrimidine degradation that plays a significant role in the pharmacokinetics of 5-fluorouracil (5-FU). In addition, a catabolite of 5-FU induces a certain toxicity, and the sensitivity of 5-FU is determined by DPD activity in tumors. DPD is thus important clinically. Drugs
openaire   +4 more sources