Results 41 to 50 of about 105,140 (274)

Dopamine receptor agonist rotigotine-loaded microspheres ameliorates sexual function deteriorated by fluoxetine in depression rats

ASN Neuro, 2021
Low dopamine levels may cause depressive symptoms. Dopamine is also involved in sexual behavior. Rotigotine is a nonergolinic dopamine agonist. Fluoxetine, an antidepressant that acts as a selective serotonin (5-HT) reuptake inhibitor, may cause moderate
Wenqian Wang, Ce Zhang, Yiqian Fan, Shumin Yue, Yunqi Yang, Rongxia Liu, Leiming Zhang, Tian Wang, Fenghua Fu   +8 more
doaj   +1 more source

Antidepressants in Surface Waters: Fluoxetine Influences Mosquitofish Anxiety-Related Behavior at Environmentally Relevant Levels.

Environmental Science and Technology, 2019
Pharmaceutical contamination is an increasing problem globally. In this regard, the selective serotonin reuptake inhibitors (SSRIs)-a group of antidepressants-are particularly concerning. By disrupting the serotonergic system, SSRIs have the potential to
Jake M. Martin, M. Bertram, Minna Saaristo, Jack B Fursdon, Stephanie L. Hannington, Bryan W. Brooks, Bryan W. Brooks, S. R. Burket, Rachel A. Molé, N. D. S. Deal, Bob B M Wong   +10 more
semanticscholar   +1 more source

Anxiolytic profile of fluoxetine as monitored following repeated administration in animal rat model of chronic mild stress

Saudi Pharmaceutical Journal, 2016
Background: Fluoxetine, a selective serotonin re-uptake inhibitor (SSRI), has been proposed to be more effective as an antidepressive drug as compared to other SSRIs.
Muhammad Farhan, Darakshan Jabeen Haleem
doaj   +1 more source

Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice

Frontiers in Pharmacology, 2020
Growing evidence suggests an important role of fluoxetine with serotonin 5-HT1A and 5-HT2C receptors in the modulation of emotion and nociception in brain areas such as the amygdala and periaqueductal gray (PAG).
Daniela Baptista-de-Souza, Daniela Baptista-de-Souza, Daniela Baptista-de-Souza, Lígia Renata Rodrigues Tavares, Lígia Renata Rodrigues Tavares, Elke Mayumi Furuya-da-Cunha, Elke Mayumi Furuya-da-Cunha, Paulo Eduardo Carneiro de Oliveira, Paulo Eduardo Carneiro de Oliveira, Lucas Canto-de-Souza, Lucas Canto-de-Souza, Ricardo Luiz Nunes-de-Souza, Ricardo Luiz Nunes-de-Souza, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza, Azair Canto-de-Souza, Azair Canto-de-Souza, Azair Canto-de-Souza   +17 more
doaj   +1 more source

Differential Rearing Alters Forced Swim Test Behavior, Fluoxetine Efficacy, and Post-Test Weight Gain in Male Rats. [PDF]

PLoS ONE, 2015
Environmental factors play a key role in the etiology of depression. The rodent forced swim test (FST) is commonly used as a preclinical model of depression, with increases in escape-directed behavior reflecting antidepressant effects, and increases in ...
David L Arndt, Christy J Peterson, Mary E Cain   +2 more
doaj   +1 more source

Terminal differentiation of adult hippocampal progenitor cells is a step functionally dissociable from proliferation and is controlled by Tis21, Id3 and NeuroD2 [PDF]

, 2017
Cell proliferation and differentiation are interdependent processes. Here, we have asked to what extent the two processes of neural progenitor cell amplification and differentiation are functionally separated.
Daniele Saraulli, Daniele Saraulli, Felice Tirone, Giorgio D’Andrea, Laura Micheli, Manuela Ceccarelli, Marco Costanzi, Roberta Gioia, Stefano Farioli-Vecchioli, Vincenzo Cestari   +9 more
core   +2 more sources

Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner

ACS Infectious Diseases, 2019
Enteroviruses (family Picornaviridae) comprise a large group of human pathogens against which no licensed antiviral therapy exists. Drug-repurposing screens uncovered the FDA-approved drug fluoxetine as a replication inhibitor of enterovirus B and D ...
Lisa Bauer, Roberto Manganaro, Birgit Zonsics, J. Strating, Priscila El Kazzi, Moira Lorenzo Lopez, Rachel Ulferts, Clara van Hoey, M. Maté, T. Langer, B. Coutard, A. Brancale, F. V. van Kuppeveld   +12 more
semanticscholar   +1 more source

Artificial Intelligence as the Next Visionary in Liquid Crystal Research

Advanced Functional Materials, EarlyView.
The functions of AI in the research laboratory are becoming increasingly sophisticated, allowing the entire process of hypothesis formulation, material design, synthesis, experimental design, and reiterative testing to be automated. In our work, we conceive how the incorporation of AI in the laboratory environment will transform the role and ...
Mert O. Astam, Ouassim L'Karkouri, Danqing Liu   +2 more
wiley   +1 more source

Detecting fluoxetine and norfluoxetine in wild bird tissues and feathers

Environment International, 2019
The contamination of the environment with human pharmaceuticals is widespread and demand for such products is mounting globally. Wild vertebrates may be at particular risk from any effects from pharmaceuticals, because of the evolutionary conservation of
Sophia E. Whitlock, M. Glória Pereira, Julie Lane, Darren Sleep, Richard F. Shore, Kathryn E. Arnold   +5 more
doaj   +1 more source

Fluoxetine increases astrocytic glucose uptake and glycolysis in corticosterone-induced depression through restricting GR-TXNIP-GLUT1 Pathway

Frontiers in Pharmacology, 2022
Antidepressant fluoxetine can affect cerebral glucose metabolism in clinic, but the underlying molecular mechanism remains poorly understood. Here, we examined the effect of fluoxetine on brain regional glucose metabolism in a rat model of depression ...
Shu-Man Pan, Yi-Fan Zhou, Na Zuo, Rui-Qing Jiao, Ling-Dong Kong, Ling-Dong Kong, Ying Pan, Ying Pan   +7 more
doaj   +1 more source