Results 51 to 60 of about 52,111 (191)

Fluoxetine increases astrocytic glucose uptake and glycolysis in corticosterone-induced depression through restricting GR-TXNIP-GLUT1 Pathway

Frontiers in Pharmacology, 2022
Antidepressant fluoxetine can affect cerebral glucose metabolism in clinic, but the underlying molecular mechanism remains poorly understood. Here, we examined the effect of fluoxetine on brain regional glucose metabolism in a rat model of depression ...
Shu-Man Pan, Yi-Fan Zhou, Na Zuo, Rui-Qing Jiao, Ling-Dong Kong, Ling-Dong Kong, Ying Pan, Ying Pan   +7 more
doaj   +1 more source

The selective serotonin reuptake inhibitor fluoxetine improves glucose homeostasis in vivo by promoting insulin secretion and maintaining functional β-cell mass

, 2018
Aim: We previously showed that therapeutically relevant concentrations of fluoxetine stimulated insulin secretion and increased beta cell proliferation in vitro.
Jones, P.M., Zariwala, M., Liu, B., Ismail, K., Moulton, C.D., Ruz‐Maldonaldo, I., Persaud, S.J.   +6 more
core   +1 more source

A Preliminary Randomized Controlled Trial of Different Treatment Regimens for Melancholic Depression

Neuropsychiatric Disease and Treatment, 2021
Yun Wang,1 Xiaohua Liu,2,3 Daihui Peng,2 Yan Wu,2 Yun’ai Su,4 Jia Xu,5 Xiancang Ma,6 Yi Li,7 Jianfei Shi,8 Xiaojing Cheng,9 Han Rong,10 Yiru Fang1,3,11 1Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of ...
Wang Y, Liu X, Peng D, Wu Y, Su Y, Xu J, Ma X, Li Y, Shi J, Cheng X, Rong H, Fang Y   +11 more
doaj  

Antidepressant Activity of Fluoxetine Analogues

, 2023
Fluoxetine, fluroxamine, sertraline, indalpine, paroxetine, alproclate, femorxetine and choroxamine belong to SSRI group of drugs. Present research work involves synthesis of fluoxetine derivatives by reacting Substituted acetophenone undergoes mannich ...
Navneet Kumar Verma
core   +1 more source

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue

Scientific Reports, 2021
To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir.
Melissa Zimniak, Luisa Kirschner, Helen Hilpert, Nina Geiger, Olga Danov, Heike Oberwinkler, Maria Steinke, Katherina Sewald, Jürgen Seibel, Jochen Bodem   +9 more
doaj   +1 more source

A terapia combinada de exercício físico e creatina induz efeito tipo-antidepressivo e aumento de BDNF no hipocampo de camundongos [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2014.Os tratamentos farmacológicos disponíveis para a depressão demandam semanas para surtir efeito e ...
Oliveira, Ágatha
core  

Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear

, 2013
The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This
Nachon, Ophelie, Cleren, Carine, Moreau, Jean-Luc, Deschaux, Olivier, Zheng, Xigeng, Deschaux, O (reprint author), Univ Nice Sophia Antipolis, Fac Sci, Dept Sci Vie, F-06108 Nice, France., Lavigne, Jennifer, Garcia, Rene   +7 more
core   +1 more source

Yeast supplementation potentiates fluoxetine's anti-depressant effect in mice via modulation of oxido-inflammatory, CREB, and MAPK signaling pathways

Current Research in Physiology
Introduction: The therapeutic potential of yeast in the management of depression is unknown. Thus, we evaluated the modulatory effect of nutritional yeast supplementation on antidepressant activity of fluoxetine in mice models of depressive-like ...
Augustina Potokiri, Noah A. Omeiza, Abayomi M. Ajayi, Paul A. Adeleke, Abdullateef I. Alagbonsi, Ezekiel O. Iwalewa   +5 more
doaj   +1 more source

Study on the effect of fluoxetine against Candida albicans, alone or combined with fluconazole [PDF]

Kouqiang yixue
Objective To evaluate the inhibitory activity of fluoxetine alone and in combination with fluconazole on Candida albicans. Methods This study used standard strains of Candida albicans, clinical isolates of Candida albicans, and drug-resistant strains of ...
SHI Banruo, WU Qiaochu, MIAO Haochen, WEI Xin
doaj   +1 more source

Biphasic Regulation of Caveolin-1 Gene Expression by Fluoxetine in Astrocytes: Opposite Effects of PI3K/AKT and MAPK/ERK Signaling Pathways on c-fos

Frontiers in Cellular Neuroscience, 2017
Previously, we reported that fluoxetine acts on 5-HT2B receptor and induces epidermal growth factor receptor (EGFR) transactivation in astrocytes. Recently, we have found that chronic treatment with fluoxetine regulates Caveolin-1 (Cav-1)/PTEN/PI3K/AKT ...
Baoman Li, Shu Jia, Tingting Yue, Li Yang, Chen Huang, Alexej Verkhratsky, Alexej Verkhratsky, Liang Peng   +7 more
doaj   +1 more source