[Simultaneous identification and detection of four novel isoxazoline drugs in bovine-origin foods using ultra-high performance liquid chromatography coupled to quadrupole/linear ion trap mass spectrometry]. [PDF]
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Treatment of crusted sarcoptic mange with fluralaner in a dog
Veterinary Record Case Reports, 2021Abstract A 4‐year‐old neutered male Lakeland terrier was presented for evaluation of allergies and onset of new crusting skin lesions. The face, dorsum, limbs and paws were diffusely covered in crusts and adherent scaling. The dog was mildly to moderately pruritic.
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State-dependent inhibition of GABA receptor channels by the ectoparasiticide fluralaner
Pesticide Biochemistry and Physiology, 2022γ-Aminobutyric acid (GABA) receptors (GABARs) are ligand-gated Cl- channels, which cause an influx of Cl- that inhibits excitation in postsynaptic cells upon activation. GABARs are important targets for drugs and pest control chemicals. We previously reported that the isoxazoline ectoparasiticide fluralaner inhibits GABA-induced currents in housefly ...
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Enantioselective Detection, Bioactivity, and Metabolism of the Novel Chiral Insecticide Fluralaner
Journal of Agricultural and Food Chemistry, 2020Fluralaner, a veterinary drug, is a potential chiral isoxazoline insecticide possessing high insecticidal and acaricidal activity. However, there is little information regarding the enantioselective effect of fluralaner. In this work, a promising chiral detection method was established with liquid chromatography-mass spectrometry in agricultural ...
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Theoretical and Experimental Study of Molecular Interactions of Fluralaner with Lipid Membranes
Journal of Agricultural and Food Chemistry, 2023Fluralaner is a relatively new insecticide belonging to the isoxazoline group, whose action mechanism involves the blocking of GABAA-receptors in the insect nervous system. Because of its high hydrophobicity, fluralaner could bioaccumulate and reach toxic local concentrations.
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