Results 141 to 150 of about 1,462 (173)

State-Dependent Inhibition of GABA Receptor Channels by the Ectoparasiticide Fluralaner

Pesticide Biochemistry and Physiology, 2022
γ-Aminobutyric acid (GABA) receptors (GABARs) are ligand-gated Cl- channels, which cause an influx of Cl- that inhibits excitation in postsynaptic cells upon activation. GABARs are important targets for drugs and pest control chemicals. We previously reported that the isoxazoline ectoparasiticide fluralaner inhibits GABA-induced currents in housefly ...
Yoshihisa Ozoe, Fumiyo Ozoe
exaly   +3 more sources

Treatment of crusted sarcoptic mange with fluralaner in a dog

Veterinary Record Case Reports, 2021
Abstract A 4‐year‐old neutered male Lakeland terrier was presented for evaluation of allergies and onset of new crusting skin lesions. The face, dorsum, limbs and paws were diffusely covered in crusts and adherent scaling. The dog was mildly to moderately pruritic.
Laura L. Quilling, Andrea T. H. Lam, Catherine A. Outerbridge, Stephen D. White   +3 more
openaire   +1 more source

Efficacy of fluralaner in 17 dogs with sarcoptic mange

Veterinary Dermatology, 2016
Background There are few licensed options for the treatment of canine sarcoptic mange. Objective To evaluate the efficacy of fluralaner in dogs with sarcoptic mange infestation.
Camilo, Romero, Rafael, Heredia, Jocelyn, Pineda, Jonathan A, Serrano, Germán D, Mendoza, Porfirio, Trápala, Alberto M, Cordero   +6 more
openaire   +2 more sources

Selection for, and characterization of, fluralaner resistance in the house fly, Musca domestica

Pesticide Biochemistry and Physiology, 2023
House flies, Musca domestica (L), are the mechanical vector of >100 human and animal pathogens, including those that are antibiotic-resistant. Given that house flies are associated closely with human and livestock activity, they present medical and veterinary health concerns.
Rachel H, Norris, Oshneil S, Baker, Edwin R, Burgess, Aaron, Tarone, Alec, Gerry, Rebecca T, Trout Fryxell, Nancy C, Hinkle, Cassandra, Olds, David, Boxler, Kenneth L, Wise, Erika T, Machtinger, Jeffrey G, Scott   +11 more
openaire   +2 more sources

Insecticidal spectrum of fluralaner to agricultural and sanitary pests

Journal of Asia-Pacific Entomology, 2017
Abstract Fluralaner, as an isoxazoline insecticide, has been developed as antiparasitic (namely Bravecto®) with selective toxicity for insect versus mammals. Even though the toxic effect of fluralaner to several insects have been already examined, but also more agricultural and sanitary insects should be tested before it could be used widely.
Cheng-Wang Sheng, Zhong-Qiang Jia, Di Liu, Hui-Zi Wu, Xu-Mei Luo, Ping-Ping Song, Lu Xu, Ying-Chuan Peng, Zhao-Jun Han, Chun-Qing Zhao   +9 more
openaire   +1 more source

Mechanisms of fluralaner antagonism of GABA receptors: A review

Pesticide Biochemistry and Physiology
Ionotropic γ-aminobutyric acid receptors (GABARs) of arthropod pests are the targets of two major groups of insecticides: blockers (IRAC Group 2) and allosteric modulators (IRAC Group 30) of GABA-gated chloride channels. Fluralaner, an isoxazoline ectoparasiticide, acts as an allosteric modulator.
Yoshihisa, Ozoe, Miho, Asahi
openaire   +2 more sources

Toxicity and Sublethal Effects of Fluralaner on Spodoptera litura Fabricius (Lepidoptera: Noctuidae)

Pesticide Biochemistry and Physiology, 2018
The increasing occurrence of resistance to chemical insecticides in insect pest populations is a serious threat to the integrity of current pest management strategies, and exploring new alternative chemistries is one important way to overcome this obstacle. Fluralaner, as a novel isoxazoline insecticide, has broad spectrum activity against a variety of
Yingchuan Peng, Tao Tang, Zhaojun Han
exaly   +3 more sources

Absolute configuration assignment of (+)‐fluralaner using vibrational circular dichroism

Chirality, 2017
AbstractThe absolute configurations of the separated enantiomers of fluralaner, a racemic animal health product used to prevent fleas and ticks, have been assigned using vibrational circular dichroism (VCD). The crystallographic structure of the active enantiomer (+)‐fluralaner has previously been shown to have the (S) configuration using small ...
John Kong, Leo A. Joyce, Jinchu Liu, Tiffany M. Jarrell, J. Chris Culberson, Edward C. Sherer   +5 more
openaire   +2 more sources

Putative pemphigus‐like reaction to oral fluralaner in a dog

Veterinary Dermatology
AbstractA 9‐month‐old mixed‐breed dog developed generalised pustular dermatitis, accompanied by lethargy and hyperthermia, 7 days after oral fluralaner administration. Dermatopathological and microbiological evaluations were consistent with a pustular acantholytic dermatitis.
Annabel Dalmau, Laura Ordeix
openaire   +2 more sources

Evaluation of the effectiveness of fluralaner against adult stages of Rhodnius prolixus in dogs

Parasitology International, 2022
Triatomines are vectors of American Trypanosomiasis also known as Chagas´ disease where several reservoirs including dogs are involved in the transmission cycle of the causal agent (Trypanosoma cruzi). Considering that the prevalence of American trypanosomiasis in dogs is higher than in humans and that dogs in addition are susceptible of this disease ...
Antonio, Ortega-Pacheco, Anabel, Poot-Ramos, Jose I, Chan-Pérez, Eduardo, Gutiérrez-Blanco, Carlos M, Acevedo-Arcique, Carlos M, Baak-Baak, Matilde, Jiménez-Coello   +6 more
openaire   +2 more sources