Results 41 to 50 of about 1,159 (176)

Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use

Parasites & Vectors, 2021
Background Sarcoptic mange causes significant animal welfare and occasional conservation concerns for bare-nosed wombats (Vombatus ursinus) throughout their range.
Vicky Wilkinson, Kotaro Tokano, David Nichols, Alynn Martin, Roz Holme, David Phalen, Kate Mounsey, Michael Charleston, Alexandre Kreiss, Ruth Pye, Elizabeth Browne, Christina Næsborg-Nielsen, Shane A. Richards, Scott Carver   +13 more
doaj   +1 more source

Functional Characterization of the Cat and Dog Wild-Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany. [PDF]

J Vet Pharmacol Ther
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Siegl L, Bethäuser M, Nürnberger D, Oswald S, Moritz A, Hamann M, Geyer J.   +6 more
europepmc   +2 more sources

The Potential of Fluralaner as a Bait Toxicant to Control Pest Yellowjackets in California

Insects, 2023
The western yellowjacket, Vespula pensylvanica (Saussure), is an important seasonal pest of recreational and outdoor venues in the western United States. Its propensity to scavenge food increases the likelihood of stinging incidences. Control measures are limited to intensive trapping and treating subterranean nests.
Michael K. Rust, Chow-Yang Lee, Ho Eun Park, Kathleen Campbell, Dong-Hwan Choe, Mary Sorensen, Andrew Sutherland, Casey Hubble, Beatriz Nobua-Behrmann, John Kabashima, Shu-Ping Tseng, Linda Post   +11 more
openaire   +5 more sources

Fluralaner 5.46% (w/w) flavored chewable tablet (Bravecto® 1-Month) is effective for treatment of canine generalized demodicosis

Parasites & Vectors, 2022
Background Orally administered fluralaner (13.64% w/w) is effective for treating canine generalized demodicosis. A study was initiated to assess the efficacy of a novel 5.46% w/w fluralaner chewable tablet formulation for monthly administration in the ...
Nadja Rohdich, Leon Meyer, Frank Guerino
doaj   +1 more source

Efficacy of fluralaner against hard tick (Rhipicephalus sanguineus) in dogs

, 2021
Fluralaner is a new molecular entity from the isoxazoline class that exhibits acaricidal and insecticidal activity and it is recommended as an anti-ticks drugs. The aim of this study is to analyze the effect of fluralaner against dog infested by tick.
Hadi, Upik Kesumawati, Bin Kamiring, Azery, Soviana, Susi, Hidayat, Syarif   +3 more
core   +1 more source

Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment

Parasites & Vectors, 2014
Background Fluralaner, a novel isoxazoline, has both acaricidal and insecticidal activity through potent blockage of GABA- and L-glutamate-gated chloride channels.
Heike Williams, David R Young, Tariq Qureshi, Hartmut Zoller, Anja R Heckeroth   +4 more
doaj   +1 more source

Effect of fluralaner on the biology, survival, and reproductive fitness of the neotropical malaria vector Anopheles aquasalis

Malaria Journal, 2023
Background Reducing mosquito abundance or interfering with its ability to support the parasite cycle can help to interrupt malaria in areas of significant risk of malaria transmission.
João Arthur Alcântara, Francys Sayara Andrade de Araújo, Andréia da Costa Paz, Rodrigo Maciel Alencar, Berta Yoná de Albuquerque Caldas, Raquel Soares Maia Godoy, Marcus Vinicius Guimarães Lacerda, Gisely Cardoso de Melo, Wuelton Marcelo Monteiro, Vanderson de Souza Sampaio, Nágila Francinete Costa Secundino, Ana Paula Marques Duarte, Rosa Amélia Gonçalves Santana, Paulo Filemon Paolucci Pimenta   +13 more
doaj   +1 more source

Field effectiveness and safety of fluralaner plus moxidectin (Bravecto® Plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats

Parasites & Vectors, 2018
Background A spot-on formulation containing fluralaner (280 mg/ml) plus moxidectin (14 mg/ml) (Bravecto® Plus) has been developed to provide broad spectrum parasite protection for cats. The effectiveness and safety of this product against ticks and fleas
Nadja Rohdich, Eva Zschiesche, Oliver Wolf, Wolfgang Loehlein, Thierry Pobel, Maria José Gil, Rainer K. A. Roepke   +6 more
doaj   +1 more source

Treatment of dogs with fluralaner reduced pyrethroid-resistant Triatoma infestans abundance, Trypanosoma cruzi infection and human-triatomine contact in the Argentine Chaco

Parasites & Vectors, 2022
Background Triatomine elimination efforts and the interruption of domestic transmission of Trypanosoma cruzi are hampered by pyrethroid resistance. Fluralaner, a long-lasting ectoparasiticide administered to dogs, substantially reduced site infestation ...
Ricardo Esteban Gürtler, Mariano Alberto Laiño, Alejandra Alvedro, Gustavo Fabián Enriquez, Natalia Paula Macchiaverna, María Sol Gaspe, Marta Victoria Cardinal   +6 more
doaj   +1 more source

Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-/-) Collies after oral administration

Parasites & Vectors, 2014
Background Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. This study investigated the safety of oral administration of fluralaner at 3 times the highest expected clinical ...
Feli M Walther, Allan J Paul, Mark J Allan, Rainer KA Roepke, Martin C Nuernberger   +4 more
doaj   +1 more source