Results 71 to 80 of about 55,050 (295)
Advanced Science, EarlyView.Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang +16 more
wiley +1 more source
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
Erroneous Activated Coagulation Time During Atrial Flutter Ablation [PDF]
, 2020 Sheldon Goldstein +2 more
openalex +1 more source
Advanced Science, EarlyView.A thin topological insulator (Bi2Te3) inserted between two single magnetic septuple layers of MnBi2Te4 is shown to convert the intrinsic antiferromagnetic interlayer coupling into robust ferromagnetism. As the Bi2Te3 spacer thickness increases from 1 to 4 quintuple layers, the weakening coercivity, Curie temperature, and interlayer coupling reveal ...
Enayet Hossain +10 more
wiley +1 more source
Active Force Dynamics in Red Blood Cells Under Non‐Invasive Optical Tweezers
Advanced Science, EarlyView.A non‐invasive method combines low‐power optical tweezers with high‐speed microscopy to simultaneously monitor local membrane forces and displacements in single human red blood cells. This dual‐channel approach reveals a mechano‐dynamic signature that correlates the cell's metabolic state with its mechanical activity. This energetic framework serves as
Arnau Dorn +5 more
wiley +1 more source
Successful catheter ablation of persistent atrial fibrillation and common atrial flutter in a patient with dextrocardia, situs inversus, and interrupted inferior vena cava with azygos continuation [PDF]
, 2021 Akiko Masumoto +4 more
openalex +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Flutter Speed Limits of Cantilever Rectangular and Tapered Plates
Al-Khawarizmi Engineering Journal, 2007 The aerodynamic and elastic forces may cause an oscillation of the structure such as the high frequency of the airfoil surfaces and the dynamic instability occurring in an aircraft in flight and failure may occur at a speed called flutter speed.
Kusay H. Jabir
doaj +2 more sources
Research progress on analysis and test methods of aircraft panel flutter
Hangkong gongcheng jinzhanAircraft panel flutter is a typical aeroelastic stability problem that occurs during supersonic flight，and is characterized by aerodynamic unilateral effects and significant structural and aerodynamic nonlinearity.
HE Chuanyang +4 more
doaj +1 more source