Results 71 to 80 of about 54,227 (294)

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Flutter Speed Limits of Cantilever Rectangular and Tapered Plates

Al-Khawarizmi Engineering Journal, 2007
The aerodynamic and elastic forces may cause an oscillation of the structure such as the high frequency of the airfoil surfaces and the dynamic instability occurring in an aircraft in flight and failure may occur at a speed called flutter speed.
Kusay H. Jabir
doaj   +2 more sources

Clinical outcomes of high-density mapping for atypical atrial flutter ablation [PDF]

, 2022
B G S Abeln, Jippe C. Balt, M N Klaver, Moniek Maarse, Vincent F. van Dijk, M. C. E. F. Wijffels, Lucas V.A. Boersma   +6 more
openalex   +1 more source

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

Advanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang, Huayan Xie, Qiang Lin, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang, Xiaoyong Dai, Guocai Wang, Yubo Zhang   +15 more
wiley   +1 more source

Incidence and Implications of Atrial Fibrillation/Flutter in Hypertension [PDF]

, 2020
Vibhu Parcha, Nirav Patel, Rajat Kalra, Joon-Seok Kim, Orlando M. Gutiérrez, Garima Arora, Pankaj Arora   +6 more
openalex   +1 more source

Puerarin Targets MIC19 to Suppress Mitochondrial Metabolism of Tumor‐Infiltrating Tregs and Enhance Anti‐tumor Immunity

Advanced Science, EarlyView.
Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li, Ziyan Song, Jianjun Ding, Yiheng Zhou, Tianning Huang, Qufei Qian, Miao Yu, Wenzhao Chen, Jiazheng Liu, Ling Lu, Qiuyang Chen   +10 more
wiley   +1 more source

Atrial flutter with 1:1 rapid wide QRS atrioventricular conduction in a patient following traditional surgical repair on atrial septal defect: a case study

, 2021
Jingxiu Li, Yanlin Wang, Fujun Zhang, Min Gao, Xueqi Li, Jing Wang, Xinxin Di, Muqiu Wang, Xin Qiu, Beibei Ding   +9 more
openalex   +1 more source

Syntaxin 3B Mediates Light‐Dependent Interactions with STXBP1 and Arrestin 4: Distinct Roles in Rods and Cones

Advanced Science, EarlyView.
The present study investigates a cone‐specific STX3 knockout model, displaying a complete loss of cone function, a later onset reduction in rod function, and photoreceptor cell death. A cone‐specific depletion of STXBP1 and ARR4 could be observed in this model.
Lars Tebbe, Larissa Ikelle, Mustafa S. Makia, Mashal Kakakhel, Muayyad R. Al‐Ubaidi, Muna I. Naash   +5 more
wiley   +1 more source

Spatial Distribution of Repetitive Electrograms Identifies a Spectrum of Organization from Atrial Fibrillation to Flutter. Abstract

, 2021
Prasanth Ganesan, Miguel Rodrigo, Brototo Deb, Ruibin Feng, Neal K. Bhatia, Albert J. Rogers, Paul Clopton, Wouter‐Jan Rappel, Sanjiv M. Narayan   +8 more
openalex   +2 more sources

Direct hepatic vein puncture and transseptal access for atrial flutter and fibrillation ablation in a patient with prior ligation of the inferior vena cava [PDF]

, 2020
Prakash Suryanarayana, Michael Ayers, Scott O. Trerotola, Saman Nazarian   +3 more
openalex   +1 more source