Results 121 to 130 of about 2,518,547 (340)
Post-processed data and graphical tools for a CONUS-wide eddy flux evapotranspiration dataset
, 2023 John Volk +25 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Magnetic flux emergence in fast rotating stars
, 2007 Fast rotating cool stars are characterised by high magnetic activity levels and frequently show dark spots up to polar latitudes. Their distinctive surface distributions of magnetic flux are investigated in the context of the solar-stellar connection by ...
Holzwarth, V.
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
FluxSimulator: An R Package to Simulate Isotopomer Distributions in Metabolic Networks
Journal of Statistical Software, 2007 The representation of biochemical knowledge in terms of fluxes (transformation rates) in a metabolic network is often a crucial step in the development of new drugs and efficient bioreactors.
Thomas W. Binsl +4 more
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Role of coronal mass ejections in the heliospheric Hale cycle [PDF]
, 2007 [1] The 11-year solar cycle variation in the heliospheric magnetic field strength can be explained by the temporary buildup of closed flux released by coronal mass ejections (CMEs).
Crooker, N. U. +4 more
core +1 more source