Results 101 to 110 of about 2,311,044 (291)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Effect of Process Parameters on Thermo-mechanical Behavior of Direct Extrusion of Aluminum Alloy

Iranian Journal of Materials Science and Engineering, 2021
Finite element analysis has been carried out to investigate the effect of various parameters on axisymmetric hot extrusion process using aluminum alloy.
Yogesh Dewang, Vipin Sharma
doaj  

A UV flux drop preceding the X-ray hard-to-soft state transition during the 2010 outburst of GX 339-4

, 2012
The black hole X-ray transient GX 339$-$4 was observed with the {\it Swift} satellite across the hard-to-soft state transition during its 2010 outburst.
Bessell, Buxton, Buxton, Cadolle Bel, Cardelli, Corbel, Corbel, Corbel, Corbel, Coriat, Dinçer, Esin, Fender, Fender, Fender, Gallo, Gandhi, Gierliński, Homan, Lewis, Maitra, Markoff, McClintock, Mineo, Motch, Motta, Pagani, Russell, Russell, Russell, Rykoff, Shahbaz, Shakura, Tang, Tomsick, van Paradijs, Wenfei Yu, Wu, Yamaoka, Yu, Yu, Yuan, Zdziarski, Zdziarski, Zhen Yan   +44 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Trend and seasonal variation of atmospheric mercury concentrations at the Cape Point GAW observatory, South Africa

E3S Web of Conferences, 2013
Gaseous elemental mercury (GEM) has been measured at the WMO Global Atmospheric Watch station at Cape Point, South Africa since September 1995. Two techniques were used: a low resolution manual technique till the end of 2004 and a high resolution ...
Brunke E.-G., Ebinghaus R., Kock H. H., Weigelt A., Labuschagne C., Slemr F.   +5 more
doaj   +1 more source

On flare-CME characteristics from Sun to Earth combining remote-sensing image data with in-situ measurements supported by modeling

, 2017
We analyze the well observed flare-CME event from October 1, 2011 (SOL2011-10-01T09:18) covering the complete chain of action - from Sun to Earth - for a better understanding of the dynamic evolution of the CME and its embedded magnetic field.
Dissauer, K., Hinterreiter, J., Rodriguez, L., Temmer, M., Thalmann, J. K., Tschernitz, J., Veronig, A. M.   +6 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Desenvolvimento de massas de revestimento cerâmico com argila caulinítica e nefelina sienito Development of ceramic tile bodies with kaolinitic clay and nepheline-syenite

Cerâmica, 2008
Este trabalho tem por objetivo adicionar tanto o fundente nefelina sienito, disponível no Estado do Rio de Janeiro, quanto o talco, fornecido por uma mineradora, em uma argila caulinítica para a obtenção de revestimento cerâmico gresificado.
C. M. F. Vieira, J. B. Soares, S. N. Monteiro   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source