Results 81 to 90 of about 2,311,044 (291)

Nongeometric Flux Compactifications

open access: yes, 2005
We investigate a simple class of type II string compactifications which incorporate nongeometric "fluxes" in addition to "geometric flux" and the usual H-field and R-R fluxes. These compactifications are nongeometric analogues of the twisted torus.
A. Dabholkar   +45 more
core   +4 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Application of Stable Isotope-Assisted Metabolomics for Cell Metabolism Studies

open access: yesMetabolites, 2014
The applications of stable isotopes in metabolomics have facilitated the study of cell metabolisms. Stable isotope-assisted metabolomics requires: (1) properly designed tracer experiments; (2) stringent sampling and quenching protocols to minimize ...
Le You, Baichen Zhang, Yinjie J. Tang
doaj   +1 more source

Homologous Flux Ropes Observed by SDO/AIA

open access: yes, 2013
We firstly present the Solar Dynamics Observatory observations of four homologous flux ropes in active region (AR) 11745 on 2013 May 20-22. The four flux ropes are all above the neutral line of the AR, with endpoints anchoring at the same region, and ...
Li, Ting, Zhang, Jun
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Digestate Application Methods and Rates with Regard to Greenhouse Gas Emissions and Crop Conditions

open access: yesAgronomy
Digestate is commonly used as a liquid organic fertilizer, as it contains nutrients that are important for plant growth and thus help reduce usage of mineral fertilizers.
Jaroslav Korba   +5 more
doaj   +1 more source

Effective Therapeutic Delivery and Bioavailability Enhancement of Pioglitazone Using Drug in Adhesive Transdermal Patch

open access: yesPharmaceutics, 2019
The administration of pioglitazone as an oral therapy is restricted due to various challenges. The aim of the current investigation was to evaluate the suitability of pioglitazone in adhesive transdermal patch as an alternative delivery system, in order ...
Anroop B. Nair   +10 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Flux réels versus flux immatériels

open access: yesCalenda, 2016
Cette journée d'étude vise à interroger la question de la construction et la production des territoires à travers les dynamiques engendrées par les flux, tant matériels qu'immatériels. En croisant les échelles, les approches et les disciplines, il s'agira de prendre en considération la multiplicité des formes spatiales des territoires et le lien étroit
openaire   +3 more sources

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