Results 11 to 20 of about 1,555,219 (293)
Flux-P: Automating Metabolic Flux Analysis [PDF]
Metabolites, 2012 Quantitative knowledge of intracellular fluxes in metabolic networks is invaluable for inferring metabolic system behavior and the design principles of biological systems.
Birgitta E. Ebert +3 more
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Computationally efficient flux variability analysis [PDF]
BMC Bioinformatics, 2010 Background Flux variability analysis is often used to determine robustness of metabolic models in various simulation conditions. However, its use has been somehow limited by the long computation time compared to other constraint-based modeling methods ...
Thiele Ines, Gudmundsson Steinn
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FLUX: A pipeline for MEG analysis
NeuroImage, 2022 Magnetoencephalography (MEG) allows for quantifying modulations of human neuronal activity on a millisecond time scale while also making it possible to estimate the location of the underlying neuronal sources.
Oscar Ferrante +6 more
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Model validation and selection in metabolic flux analysis and flux balance analysis. [PDF]
Biotechnol Prog, 2023 Abstract 13C‐Metabolic Flux Analysis (13C‐MFA) and Flux Balance Analysis (FBA) are widely used to investigate the operation of biochemical networks in both biological and biotechnological research. Both methods use metabolic reaction network models of metabolism operating at steady state so that reaction rates ...
Kaste JAM, Shachar-Hill Y.
europepmc +5 more sources
Generic flux coupling analysis [PDF]
Mathematical Biosciences, 2015 Flux coupling analysis (FCA) has become a useful tool for aiding metabolic reconstructions and guiding genetic manipulations. Originally, it was introduced for constraint-based models of metabolic networks that are based on the steady-state assumption.
Reimers, Arne C. +2 more
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Bayesian metabolic flux analysis reveals intracellular flux couplings [PDF]
Bioinformatics, 2019 Abstract Motivation Metabolic flux balance analysis (FBA) is a standard tool in analyzing metabolic reaction rates compatible with measurements, steady-state and the metabolic reaction network stoichiometry.
Osmala, Maria +7 more
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Principal metabolic flux mode analysis [PDF]
Bioinformatics, 2017 Abstract Motivation In the analysis of metabolism, two distinct and complementary approaches are frequently used: Principal component analysis (PCA) and stoichiometric flux analysis. PCA is able to capture the main modes of variability in a set of experiments and does not make many prior ...
Bhadra, Sahely +4 more
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Frontiers in Bioengineering and Biotechnology, 2020 For many years now, Bacillus megaterium serves as a microbial workhorse for the high-level production of recombinant proteins in the g/L-scale. However, efficient and stable production processes require the knowledge of the molecular adaptation ...
Thibault Godard +11 more
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Analytical Considerations of Stable Isotope Labelling in Lipidomics
Biomolecules, 2018 Over the last two decades, lipids have come to be understood as far more than merely components of cellular membranes and forms of energy storage, and are now also being implicated to play important roles in a variety of diseases, with lipid biomarker ...
Alexander Triebl, Markus R. Wenk
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Quantitative flux analysis in mammals. [PDF]
Nat Metab, 2021 Altered metabolic activity contributes to the pathogenesis of a number of diseases, including diabetes, heart failure, cancer, fibrosis and neurodegeneration. These diseases, and organismal metabolism more generally, are only partially recapitulated by cell culture models. Accordingly, it is important to measure metabolism in vivo.
Bartman CR, TeSlaa T, Rabinowitz JD.
europepmc +3 more sources