Results 1 to 10 of about 607 (126)

Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation† [PDF]

Angewandte Chemie - International Edition, 2020
AbstractThe fly agaric, Amanita muscaria, is widely known for its content of the psychoactive metabolites ibotenic acid and muscimol. However, their biosynthetic pathway and the respective enzymes are entirely unknown. 50 years ago, the biosynthesis was hypothesized to start with 3‐hydroxyglutamate.
Sebastian Obermaier, Michael Müller
exaly   +7 more sources

HARMFULNESS AND POTENTIAL HEALTH BENEFITS OF THE FLY AGARIC (AMANITA MUSCARIA): A LITERATURE REVIEW

Health Problems of Civilization
The fly agaric (Amanita muscaria) is widely considered a poisonous species with psychedelic effects. Patients report to hospital after consuming it with symptoms such as confusion, dizziness, agitation and ataxia.
Marcin Weiner
exaly   +4 more sources

A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation. [PDF]

Angew Chem Int Ed Engl
The fatal mushroom toxin l‐(+)‐muscarine is one of the most prominent natural products. We elucidated its biosynthetic origin in the sweating mushroom Collybia rivulosa based on incorporation of stable isotope‐labeled compounds and extensive mass spectrometric analyses.
Dörner S, Rogge K, Trottmann F, Hertweck C, Hoffmeister D.   +4 more
europepmc   +3 more sources

Acute <i>Amanita muscaria</i> Toxicity: A Literature Review and Two Case Reports in Elderly Spouses Following Home Preparation. [PDF]

Toxins (Basel)
Amanita muscaria (L.) Lam., commonly known as fly agaric, remains an uncommon yet clinically important cause of acute mushroom intoxication. Although typically associated with mild to moderate neuropsychiatric disturbances, the mushroom’s toxic profile ...
Stoeva-Grigorova S, Yarabanova I, Radeva-Ilieva M, Ivanova D, Zlateva S, Marinov P.   +5 more
europepmc   +2 more sources

Wherefore the Magic? The Evolutionary Role of Psilocybin in Nature. [PDF]

Ecol Evol
This study explores the evolutionary role of psilocybin, the psychedelic compound found in Psilocybe mushrooms. We provide the first experimental tests of defence and community‐level evidence for invertebrate responses to psilocybin‐producing fungi, revealing significant negative effects on invertebrate locomotion, development, and survival.
Matthews Nicholass KJ, Flis I, Hanley ME, Knight ME, Lane SM, Littlejohn G, Thom MDF, Billington RA, Boden R, Cummins R, Green BJ, Griffin C, Jones S, Salmon D, Sleep I, Smirnoff N, Ellis JS.   +16 more
europepmc   +2 more sources

Equipped for success: genomes and metabolomes of the European Amanita muscaria are conserved in its novel South African range. [PDF]

New Phytol
Summary Plants and soils have been moved around the world for centuries, but invasive mushrooms receive scant attention. The Amanita muscaria species complex was introduced to South Africa in the context of forestry, but its origins, ecology and recent evolution are unstudied. We sequenced the genomes of 24 Northern and Southern Hemisphere A. muscaria,
Nickles GR, Stokes CK, Narh DL, Lynn KMT, Fuqua SR, Bryan C, Allen BM, Bivins CP, Woo Bok J, Brewer JS, Buthelezi ST, Clark JPRM, Coon KL, Corby LR, Coetzee MPA, Dewing C, Duong TA, Harris MA, Keller NP, Kopotsa K, Lane FA, Nichols HL, Nieuwoudt A, Nuñez MA, Medina Munoz ME, Park SC, Pham NQ, Ryan KT, Solís M, Vilgalys R, Wallace JM, Wang YW, Wingfield BD, Wingfield MJ, Worley TK, Zallek TA, Zamanian M, Hoeksema JD, Drott MT, Pringle A.   +39 more
europepmc   +2 more sources

Fatal poisoning of Old Polish ducks with Amanita muscaria. [PDF]

BMC Vet Res
Background Amanita muscaria (fly agaric) is a poisonous mushroom containing ibotenic acid (IBA) and muscimol (MUS), two neuroactive alkaloids capable of causing severe or fatal intoxication.
Stępień-Pyśniak D, Tutaj K, Niczyporuk JS, Sell B, Marek A, Piekarska K, Ognik K.   +6 more
europepmc   +2 more sources

Amanita muscaria in the evolving novel psychoactive substances landscape - toxicological risks and clinical implications: a narrative review. [PDF]

Front Pharmacol
The rapid evolution of the novel psychoactive substances market has blurred the boundaries between synthetic “designer drugs” and other emerging psychoactive products distributed outside traditional regulatory frameworks.
Ordak M.
europepmc   +2 more sources

Mycotoxins in Basidiomycete Mycelium and Fruiting Bodies: Implications for Eu Novel Food Assessment and Selected International Regulatory Frameworks. [PDF]

Compr Rev Food Sci Food Saf
ABSTRACT Advances in technology have enabled the efficient and sustainable production of basidiomycete vegetative mycelium, particularly from Pleurotus species, as a novel food source. However, mycelium has yet to receive regulatory approval in many global markets, requiring a better understanding of factors affecting its safety.
Berglund NEW, Lankinen PV, Mikkonen KS.
europepmc   +2 more sources

Self-administered complementary and alternative methods of treating mental disorders among students in Wrocław: a cross-sectional study. [PDF]

Front Public Health
IntroductionMental health disorders such as depression are a rising issue among university students. Some of them use complementary and alternative medicine (CAM) as self-administered therapy instead of or together with professional care.
Sobieraj J, Sleziak J, Szyszka M, Błażejewska M, Łukańko K, Soczomska P, Bodziony K, Piotrowski P.   +7 more
europepmc   +2 more sources