Amanita muscaria in the evolving novel psychoactive substances landscape - toxicological risks and clinical implications: a narrative review [PDF]
Frontiers in PharmacologyThe rapid evolution of the novel psychoactive substances market has blurred the boundaries between synthetic “designer drugs” and other emerging psychoactive products distributed outside traditional regulatory frameworks.
Michal Ordak
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Ibotenic Acid and Muscimol in Amanita muscaria: Chemistry, Sources of Variability, Analytical Determination, and Toxicological Significance [PDF]
MoleculesAmanita muscaria contains two structurally related neuroactive isoxazole metabolites, ibotenic acid (IA) and muscimol (MUS), which differ markedly in pharmacological activity.
Andrzej Günther +2 more
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Safety and Efficacy of Natural and Conventional Psychiatric Treatments: A Comparative Review of Mushroom-Derived Compounds and Medicinal Plants in the Management of Mental Disorders [PDF]
MoleculesStandard pharmacotherapy for mental disorders, including depression and anxiety, is supported by extensive clinical validation and international treatment guidelines. However, it is frequently associated with limitations such as adverse side effects, low
Katarzyna Gawłowska +8 more
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Development of a PCR Assay Targeting the iboH Gene to Assess the Distribution of Ibotenic Acid/Muscimol Biosynthesis Potential in the Genus Amanita [PDF]
Journal of FungiIbotenic acid and muscimol, synthesized by the ibotenic acid biosynthetic gene cluster (ibo BGC) in Amanita species, are two of the primary neurotoxins responsible for mushroom poisoning incidents worldwide.
Zheng-Mi He, Jia-Xi Li
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Contribution of the anterior lateral motor cortex to predictive postural control in rats [PDF]
Scientific ReportsPredictive postural control is a motor function that enables animals to manage expected mechanical disturbances. The rodent anterior lateral motor cortex (ALM) may contribute to this function through interactions with the cerebellum; however, the ...
Akira Konosu +4 more
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In vitro effects of synthetic muscimol and an extract from Amanita muscaria on human recombinant MAOB enzyme [PDF]
Pharmacia, 2021 The effects of synthetic muscimol and an extract from Amanita muscaria, containing this compound on the activity of human recombinant MAOB enzyme (hMAOB) were studied. Muscimol had statistically significant inducing effect on hMAOB at concentrations 0.25–
Maria Voynova +3 more
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Muscimol inhibits plasma membrane rupture and ninjurin-1(NINJ1) oligomerization during pyroptosis
Communications Biology, 2023 Pyroptosis is a cell death process that causes inflammation and contributes to numerous diseases. Pyroptosis is mediated by caspase-1 family proteases that cleave the pore-forming protein gasdermin D, causing plasma membrane rupture and release of ...
Andreas B. den Hartigh +4 more
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A Method to Quantify Drosophila Behavioral Activities Induced by GABAA Agonist Muscimol
Bio-Protocol, 2021 Muscimol is a psychoactive isoxazole derived from the mushroom Amanita muscaria. As a potent GABAA receptor agonist, muscimol suppresses the activity of the central nervous system, reduces anxiety and induces sleep.
M Karim
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The Deceptive Mushroom: Accidental Amanita muscaria Poisoning
European Journal of Case Reports in Internal Medicine, 2021 Amanita muscaria is considered to be one of the most remarkable and beautiful mushrooms. It has a red or orange cap covered with small white plaques and its distinctive appearance makes accidental and severe intoxication very rare.
Francesca Irene Rampolli +3 more
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Frontiers in Neural Circuits, 2021 It is well known that communication between the medial prefrontal cortex (mPFC) and the ventral hippocampus (vHPC) is critical for various cognitive and behavioral functions.
Daniela Cernotova +2 more
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