Results 1 to 10 of about 13,955 (172)

Bicuculline from Forsythia suspensa attenuates liver fibrosis via TLR4/MD2 inhibition and suppression of MyD88/NF-κB signaling [PDF]

Computational and Structural Biotechnology Journal
Liver fibrosis, a cardinal feature of chronic liver injury, involves hepatic stellate cells (HSCs) activation and excessive extracellular matrix (ECM) deposition. Upon liver fibrosis, TLR4 is highly expressed on HSCs and Kupffer cells.
Xiaozheng Zhang, Guicai Wu, Sili Peng, Haoran Xu, Kai Li, Tingjuan Huang, Zhizhen Liu   +6 more
doaj   +2 more sources

GABA receptor antagonism elicits feeding in the septohypothalamic nucleus [PDF]

Frontiers in Behavioral Neuroscience
IntroductionCurrent rates of obesity and eating disorders have been steadily increasing, highlighting the importance of understanding the neural circuits of eating.
Ivett Gabriella, Vandana Nambiar, Chlinton Kuang, Abinanda Mukundan, Jonathan Dang, Aneerudh Venkatraghavan, B. Glenn Stanley, B. Glenn Stanley   +7 more
doaj   +2 more sources

Bicuculline reversal of aminoglycoside O-nucleotidyltransferase EanT-1–mediated kanamycin resistance [PDF]

BMC Microbiology
Background Kanamycin, an aminoglycoside, is an effective broad-spectrum antimicrobial agent against bacterial infections. However, the clinical efficacy of aminoglycosides has been overshadowed by the emergence of resistance mechanisms involving enzyme ...
Jiahui Wang, Minghui Yu, Mingzhen Zhang, Zhihui Meng, Peitong Yang, Xingyu Cui, Ziqian Yu, Yongan Wang, Gongli Zong   +8 more
doaj   +2 more sources

Network pharmacology integrated with molecular docking and experimental validation elucidates the therapeutic potential of Forsythiae Fructus extract against hepatitis B virus-related hepatocellular carcinoma [PDF]

Frontiers in Oncology
BackgroundForsythiae Fructus (FF), a widely used traditional Chinese medicine, possesses anti-inflammatory, antiviral, and anticancer properties. However, the precise anticancer mechanisms of FF against hepatitis B virus (HBV)-related hepatocellular ...
Fuqing Chen, Yifan Cai, Changzhou Chen, Jianyin Zhou   +3 more
doaj   +2 more sources

Early postnatal exposure to bicuculline modulates E/I balance and induces ASD-like behavioral phenotypes in mice [PDF]

Animal Cells and Systems
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social interaction deficits and repetitive behaviors. While precise causes of ASD remain elusive, growing evidence highlights that an imbalance in excitatory and inhibitory
Dongpil Shin, Eunbi Cho, Kwanghoon Park, ChiHye Chung, Dong Hyun Kim, Se Jin Jeon, Chan Young Shin   +6 more
doaj   +2 more sources

Impulsive and compulsive behaviors can be induced by opposite GABAergic dysfunctions inside the primate ventral pallidum

Frontiers in Systems Neuroscience, 2022
Introduction: The ventral pallidum (VP) is central in the limbic Basal Ganglia circuit, controlling both appetitive (approach) and aversive (avoidance) motivated behaviors.
Yosuke Saga, Laurent Galineau, Léon Tremblay, Léon Tremblay   +3 more
doaj   +1 more source

Modularity and neuronal heterogeneity: Two properties that influence in vitro neuropharmacological experiments

Frontiers in Cellular Neuroscience, 2023
IntroductionThe goal of this work is to prove the relevance of the experimental model (in vitro neuronal networks in this study) when drug-delivery testing is performed.MethodsWe used dissociated cortical and hippocampal neurons coupled to Micro ...
Martina Brofiga, Martina Brofiga, Fabio Poggio, Francesca Callegari, Mariateresa Tedesco, Paolo Massobrio, Paolo Massobrio, Paolo Massobrio   +7 more
doaj   +1 more source

Epileptiform activity influences theta-burst induced LTP in the adult hippocampus: a role for synaptic lipid raft disruption in early metaplasticity?

Frontiers in Cellular Neuroscience, 2023
Non-epileptic seizures are identified as a common epileptogenic trigger. Early metaplasticity following seizures may contribute to epileptogenesis by abnormally altering synaptic strength and homeostatic plasticity.
José D. Carvalho-Rosa, José D. Carvalho-Rosa, Nádia C. Rodrigues, Nádia C. Rodrigues, Armando Silva-Cruz, Sandra H. Vaz, Sandra H. Vaz, Diana Cunha-Reis   +7 more
doaj   +1 more source

Anticonvulsant Effects of Fractions Isolated from Dinoponera quadriceps (Kempt) Ant Venom (Formicidae: Ponerinae)

Toxins, 2016
Natural products, sources of new pharmacological substances, have large chemical diversity and architectural complexity. In this context, some toxins obtained from invertebrate venoms have anticonvulsant effects.
Diana Aline Morais Ferreira Nôga, Luiz Eduardo Mateus Brandão, Fernanda Carvalho Cagni, Delano Silva, Dina Lilia Oliveira de Azevedo, Arrilton Araújo, Wagner Ferreira dos Santos, Antonio Miranda, Regina Helena da Silva, Alessandra Mussi Ribeiro   +9 more
doaj   +1 more source

α-Pinene influence on pulpal pain-induced learning and memory impairment in rats via modulation of the GABAA receptor

Advanced Biomedical Research, 2022
Background: This study investigated the effect of central administration of α-pinene and the interaction of α-pinene with GABAA receptor on pulpal nociception-induced changes in learning and memory performances in rats.
Forouzan Rafie, Razieh Kooshki, Mehdi Abbasnejad, Iran Rahbar, Maryam Raoof, Amir Hossein Nekouei   +5 more
doaj   +1 more source