Results 21 to 30 of about 13,955 (172)

The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats

Frontiers in Aging Neuroscience, 2015
In women, high levels of natural progesterone have been associated with detrimental cognitive effects via the maternal amnesia phenomenon as well as in controlled experiments.
B. Blair Braden, B. Blair Braden, B. Blair Braden, Melissa L. Kingston, Elizabeth eWhitton, Courtney N. Lavery, Candy W.S. Tsang, Heather Allyson Bimonte-Nelson, Heather Allyson Bimonte-Nelson   +8 more
doaj   +1 more source

The Interaction Between the Ventrolateral Preoptic Nucleus and the Tuberomammillary Nucleus in Regulating the Sleep-Wakefulness Cycle

Frontiers in Neuroscience, 2020
The ventrolateral preoptic nucleus (VLPO) in the anterior hypothalamus and the tuberomammillary nucleus (TMN) in the posterior hypothalamus are critical regions which involve the regulation of sleep-wakefulness flip-flop in the central nervous system ...
Juan Cheng, Fang Wu, Fang Wu, Mingrui Zhang, Ding Ding, Ding Ding, Sumei Fan, Guihai Chen, Jin Zhang, Jin Zhang, Liecheng Wang   +10 more
doaj   +1 more source

Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors

Frontiers in Pharmacology, 2019
Patients with liver cirrhosis may develop minimal hepatic encephalopathy (MHE) with mild cognitive impairment. Hyperammonemia is a main contributor to cognitive impairment in MHE, which is mediated by neuroinflammation.
Michele Malaguarnera, Marta Llansola, Tiziano Balzano, Belén Gómez-Giménez, Carles Antúnez-Muñoz, Núria Martínez-Alarcón, Rahebeh Mahdinia, Rahebeh Mahdinia, Vicente Felipo   +8 more
doaj   +1 more source

Exercise training increases GAD65 expression, restores the depressed GABAA receptor function within the PVN and reduces sympathetic modulation in hypertension

Physiological Reports, 2019
GABAergic inhibitory input within the paraventricular hypothalamic nucleus (PVN) plays a key role in restraining sympathetic outflow. Although experimental evidence has shown depressed GABAA receptor function plus sympathoexcitation in hypertension and ...
Nilson C. Ferreira‐Junior, Adriana Ruggeri, Sebastião D. Silva Jr, Thais T. Zampieri, Alexandre Ceroni, Lisete C. Michelini   +5 more
doaj   +1 more source

Extracellular Hypothalamic γ-Aminobutyric Acid (GABA) and L-Glutamic Acid Concentrations in Response to Bicuculline in a Genetic Absence Epilepsy Rat Model

Journal of Pharmacological Sciences, 2008
The posterior part of the hypothalamus plays a vital role in the homeostatic processes of the internal environment, including blood pressure and heart rate regulation, by means of γ-aminobutyric acid (GABA)ergic and glutamatergic neurotransmission.
Hasan R. Yananli, Berna Terzioglu, M. Zafer Goren, Rezzan G. Aker, Cenk Aypak, Filiz Y. Onat   +5 more
doaj   +1 more source

Configuration of Bicuculline, a GABA Antagonist | [PDF]

Nature New Biology, 1973
WE are grateful to Gilardi1 for drawing attention to our use2 of the incorrect configuration of bicuculline. We have in fact, in more recent publications3, 4, used the correct configuration as determined by optical rotatory dispersion and circular dichroism measurements5.
G A, Johnston, D R, Curtis
openaire   +2 more sources

Central Actions of 3α,5α-THP Involving NMDA and GABAA Receptors Regulate Affective and Sexual Behavior of Female Rats

Frontiers in Behavioral Neuroscience, 2020
The neurosteroid, 5α-pregnan-3α-ol-20-one (known as “allopregnanolone” or 3α,5α-THP), is produced in the midbrain ventral tegmental area (VTA), independent of peripheral sources of progestogens, where it has potential actions at N-methyl-D-aspartate ...
Cheryl A. Frye, Cheryl A. Frye, Cheryl A. Frye, Cheryl A. Frye, Alaa Qrareya, Danielle C. Llaneza, Jason J. Paris, Jason J. Paris   +7 more
doaj   +1 more source

Propagation of epileptiform events across the corpus callosum in a cingulate cortical slice preparation. [PDF]

PLoS ONE, 2012
We report on a novel mouse in vitro brain slice preparation that contains intact callosal axons connecting anterior cingulate cortices (ACC). Callosal connections are demonstrated by the ability to regularly record epileptiform events between hemispheres
Jeffrey Walker, Gregory Storch, Bonnie Quach-Wong, Julian Sonnenfeld, Gloster Aaron   +4 more
doaj   +1 more source

Effect of intracerebroventricular injection of GABA receptors antagonists on morphine-induced changes in GABA and GLU transmission within the mPFC: an in vivo microdialysis study [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Many studies have focused on ventral tegmental area than of other mesocorticolimbic areas, and implicated a key role for the medial prefrontal cortex (mPFC) in the development of addictive behaviors.
Effat Ramshini, Hojjat allah Alaei, Parham Reisi, naser Naghdi, Hossein Afrozi, Samaneh Alaei, Maryam Alehashem, Shahrzad Eftekharvaghefi   +7 more
doaj   +1 more source

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma [PDF]

Advanced science
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Hong E, Lin C, Long W, Kim I, Xiong M, Wu Z, Rao S, Wang Q.   +7 more
europepmc   +2 more sources