Results 11 to 20 of about 13,955 (172)
Spinal Mechanisms of Testosterone Involved in Itch Regulation. [PDF]
CNS Neurosci TherTestosterone serves as an endogenous anti‐pruritic hormone underlying sex‐dependent itch differences. In the spinal dorsal horn, testosterone binds androgen receptors on GABAergic interneurons to enhance GABA release, suppressing GRPR+ − pruriceptive neurons through GABAA receptors and alleviating acute/chronic itch alongside itch‐comorbid anxiety ...
Chen L +5 more
europepmc +2 more sources
1,2-propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia. [PDF]
Animal Model Exp MedThis study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Li X, Chen Y, Xiao X, Xu G.
europepmc +2 more sources
Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures. [PDF]
Neuropsychopharmacol RepThis study demonstrated that sleep deprivation induces transcriptomic changes in mice and rats similar to those observed in various models of neuronal hyperexcitation. These findings suggest a potential link between sleep deprivation and neuropsychiatric disorders.
Chatzigiannis MM +2 more
europepmc +2 more sources
PLoS ONE, 2020 Auditory steady-state responses (ASSRs) are states in which the electrical activity of the brain reacts steadily to repeated auditory stimuli. They are known to be useful for testing the functional integrity of neural circuits in the cortex, as well as ...
Mayako Yamazaki +4 more
doaj +1 more source
GABAergic Control of Nigrostriatal and Mesolimbic Dopamine in the Rat Brain
Frontiers in Behavioral Neuroscience, 2018 Purpose: The present study assessed the effects of the GABAA receptor (R) agonist muscimol (MUS), and the GABAAR antagonist bicuculline (BIC) on neocortical and subcortical radioligand binding to dopamine D2/3Rs in relation to motor and exploratory ...
Susanne Nikolaus +10 more
doaj +1 more source
Ketogenic diet sensitizes glucose control of hippocampal excitability1
Journal of Lipid Research, 2014 A high-fat low-carbohydrate ketogenic diet (KD) is an effective treatment for refractory epilepsy, yet myriad metabolic effects in vivo have not been reconciled clearly with neuronal effects.
Masahito Kawamura, Jr. +4 more
doaj +1 more source
Effect of intrathecal glycine and related amino acids on the allodynia and hyperalgesic action of strychnine or bicuculline in mice [PDF]
Korean Journal of Anesthesiology, 2010 BackgroundThe intrathecal (IT) administration of glycine or GABAA receptor antagonist result in a touch evoked allodynia through disinhibition in the spinal cord.
Eui Sung Lim, Il Ok Lee
doaj +1 more source
High Frequency Oscillations in Rat Hippocampal Slices: Origin, Frequency Characteristics, and Spread
Frontiers in Neurology, 2020 Field potential oscillations reflect repetitive firing and synaptic activity by ensembles of neurons in certain areas of the brain. They can be distinguished as slow (e.g., alpha, delta, and theta), fast (e.g., beta and gamma), and high frequency ...
Isaac Naggar +3 more
doaj +1 more source
Activation of brain metabolism and fos during limbic seizures: The role of Locus Coeruleus
Neurobiology of Disease, 2008 The noradrenergic nucleus Locus Coeruleus (LC) densely innervates limbic structures. In rats, the damage to LC by the neurotoxin DSP-4, converts episodic limbic seizures induced by bicuculline infusion in the anterior piriform cortex (APC) into self ...
Filippo S. Giorgi +9 more
doaj +1 more source
Acta Veterinaria, 2018 Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist.
Katarina Savić Vujović +7 more
doaj +1 more source