Development of a PCR Assay Targeting the iboH Gene to Assess the Distribution of Ibotenic Acid/Muscimol Biosynthesis Potential in the Genus Amanita [PDF]
Journal of FungiIbotenic acid and muscimol, synthesized by the ibotenic acid biosynthetic gene cluster (ibo BGC) in Amanita species, are two of the primary neurotoxins responsible for mushroom poisoning incidents worldwide.
Zheng-Mi He, Jia-Xi Li
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Preliminary study on the time-correlation changes in brain neurotransmitters of mice exposed to mushroom toxin ibotenic acid [PDF]
Frontiers in NeuroscienceBackgroundMushroom poisoning represents a significant food safety issue globally, particularly neurotoxic mushroom poisoning, which raises considerable concern due to its potential to induce central nervous system symptoms. Ibotenic acid is identified as
Ruanxian Dai +10 more
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Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats [PDF]
Saudi Pharmaceutical Journal, 2022 Inflammation-mediated alterations in glutamate neurotransmission constitute the most important pathway in the pathophysiology of various brain disorders. The excessive signalling of glutamate results in excitotoxicity, neuronal degeneration, and neuronal
Sibi P Ittiyavirah +7 more
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The distribution and evolution of muscarine and the ibotenic acid biosynthetic gene cluster within the genus Amanita section Amanita revealed by phylogenomics [PDF]
IMA FungusNumerous severe cases of neurotoxic mushroom poisoning worldwide are caused by ibotenic acid and muscimol produced by specific species belonging to section Amanita of the genus Amanita.
Yu-Ting Su +7 more
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Poisoning from Ingestion of Fungus-Infected Cicada Nymphs: Characteristics and Clinical Outcomes of Patients in Thailand [PDF]
Toxins, 2023 The current data regarding poisoning associated with ingestion of fungus-infected cicada nymphs are limited. We performed a retrospective cohort study of patients who ingested fungus-infected cicada nymphs and were referred to the Ramathibodi Poison ...
Satariya Trakulsrichai +6 more
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Ibotenic Acid and Muscimol in Amanita muscaria: Chemistry, Sources of Variability, Analytical Determination, and Toxicological Significance [PDF]
MoleculesAmanita muscaria contains two structurally related neuroactive isoxazole metabolites, ibotenic acid (IA) and muscimol (MUS), which differ markedly in pharmacological activity.
Andrzej Günther +2 more
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Inactivation of Dorsolateral Prefrontal Cortex During Auditory Working Memory [PDF]
Journal of Integrative NeuroscienceBackground: The dorsolateral prefrontal cortex (DLPFC) is a critical node in the working memory (WM) neural circuit, established through neurophysiology, neuropsychology, and neuroimaging studies in humans and nonhuman primates.
Bethany Plakke +3 more
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Amanita muscaria in the evolving novel psychoactive substances landscape - toxicological risks and clinical implications: a narrative review [PDF]
Frontiers in PharmacologyThe rapid evolution of the novel psychoactive substances market has blurred the boundaries between synthetic “designer drugs” and other emerging psychoactive products distributed outside traditional regulatory frameworks.
Michal Ordak
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Safety and Efficacy of Natural and Conventional Psychiatric Treatments: A Comparative Review of Mushroom-Derived Compounds and Medicinal Plants in the Management of Mental Disorders [PDF]
MoleculesStandard pharmacotherapy for mental disorders, including depression and anxiety, is supported by extensive clinical validation and international treatment guidelines. However, it is frequently associated with limitations such as adverse side effects, low
Katarzyna Gawłowska +8 more
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INTRAHIPPOCAMPAL ADMINISTRATION OF IBOTENIC ACID INDUCED CHOLINERGIC DYSFUNCTION via NR2A/NR2B EXPRESSION: IMPLICATIONS OF RESVERATROL AGAINST ALZHEIMER DISEASE PATHOPHYSIOLOGY [PDF]
Frontiers in Molecular Neuroscience, 2016 Although several drugs revealed moderate amelioration of symptoms, none of them have sufficient potency to prevent or reverse the progression towards Alzheimer’s disease (AD) pathology.
Chennakesavan eKarthick +3 more
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