Results 1 to 10 of about 2,758 (169)

Evolution of the Toxins Muscarine and Psilocybin in a Family of Mushroom-Forming Fungi [PDF]

PLoS ONE, 2013
Mushroom-forming fungi produce a wide array of toxic alkaloids. However, evolutionary analyses aimed at exploring the evolution of muscarine, a toxin that stimulates the parasympathetic nervous system, and psilocybin, a hallucinogen, have never been ...
Pawel Kosentka, Shawn R. Campagna, Martin Ryberg   +2 more
exaly   +2 more sources

The distribution and evolution of muscarine and the ibotenic acid biosynthetic gene cluster within the genus <i>Amanita</i> section <i>Amanita</i> revealed by phylogenomics. [PDF]

IMA Fungus
Numerous severe cases of neurotoxic mushroom poisoning worldwide are caused by ibotenic acid and muscimol produced by specific species belonging to section Amanita of the genus Amanita.
Su YT, He ZM, Yang YZ, Xu F, Lai MM, Yang ZL, Zhang P, Chen ZH.   +7 more
europepmc   +4 more sources

Phylogenetic analysis, morphological studies, element profiling, and muscarine detection reveal a new toxic Inosperma (Inocybaceae, Agaricales) species from tropical China. [PDF]

Front Microbiol, 2023
Tropical Asian collections of Inosperma are usually poisonous mushrooms that have caused many poisoning incidents. However, the species diversity and the toxic mechanisms of these Inosperma species are still unclear.
Zhou YL, Deng LS, Yang SD, Liu CF, Fan YG, Yu WJ.   +5 more
europepmc   +2 more sources

Mixed toxin profiles in two new and one known species of Inocybe (Inocybaceae) from northern China [PDF]

MycoKeys
Mushroom poisoning has become a serious food safety issue in China. Poisoning incidents caused by species of Inocybaceae have been continuously reported from tropical to temperate regions of China in recent years.
Liang J, Chen X, Liu T, Zhang Y, Sun C, Li Z, Zhong J, Li H, Fan Y, Xu F.   +9 more
europepmc   +4 more sources

Synergistic mechanisms of medullary cholinergic-serotonergic pathway interactions in regulating neuronal excitability and locomotor activities. [PDF]

Commun Biol
Medullary serotonergic (5-HT) neurons play a pivotal role in locomotor initiation. While these neurons receive cholinergic innervation, the functional consequences and underlying mechanisms remain poorly understood. Using ePet-EYFP transgenic mice (P3–P6)
Cheng Y, Dai Y, Ge R, Zhang Q.
europepmc   +2 more sources

Effects of ketamine and propofol on muscarinic plateau potentials in rat neocortical pyramidal cells. [PDF]

PLoS One
Propofol and ketamine are widely used general anaesthetics, but have different effects on consciousness: propofol gives a deeply unconscious state, with little or no dream reports, whereas vivid dreams are often reported after ketamine anaesthesia ...
Fleiner AS, Kolnier D, Hagger-Vaughan N, Ræder J, Storm JF.   +4 more
europepmc   +2 more sources

Mushroom poisoning: An updated review. [PDF]

Turk J Emerg Med
Mushrooms have been consumed frequently worldwide since ancient times. In addition to edible and harmless species, there are also poisonous species that cause a wide range of clinical syndromes, from simple gastrointestinal (GI) irritation to death ...
Tuğcan MO, Akpınar AA.
europepmc   +2 more sources

From dopamine to muscarine: xanomeline-trospium (KarXT) as a novel direction in the psychopharmacotherapy of schizophrenia. [PDF]

Front Pharmacol
Schizophrenia is a severe chronic mental disease with considerable prevalence and social load. Its treatment relies on both typical and atypical antipsychotics, whose primary mechanism of action involves dopamine D2 receptor blockade, with atypical ...
Żełabowski K, Pichowicz W, Dembowska J, Szwajkowski M, Mykhailova D, Wurm G, Biedka K, Błaszczyk K, Piotrowski P.   +8 more
europepmc   +2 more sources

Additions to the <i>Inocybe</i> sect. <i>Leptocybe</i> (Agaricales) in China: new species from tropical rainforests, new geographical distributions, and toxin detection. [PDF]

Front Microbiol
Inocybe is a cosmopolitan genus of ectomycorrhizal fungi within the family Inocybaceae. Members of this genus are recognized as a group of toxic mushrooms linked to poisoning incidents worldwide.
Gao JL, Wu XP, Zhou YL, Yu WJ, Fan YG.
europepmc   +2 more sources

Toxin Profiling of <i>Amanita citrina</i> and <i>A. sinocitrina</i>: First Report of Buiotenine Detection. [PDF]

Toxins (Basel)
Amanita species are widely distributed worldwide. Many of these species are poisonous and can cause health problems, resulting in morbidity and mortality.
Zhang YZ, Yao Y, Zhang KP, Liang JQ, Zhong JJ, Li ZF, Li HJ, Xu F.   +7 more
europepmc   +2 more sources