Results 31 to 40 of about 2,758 (169)

Caveolin-1: Functional Insights into Its Role in Muscarine- and Serotonin-Induced Smooth Muscle Constriction in Murine Airways

Frontiers in Physiology, 2017
An increased bronchoconstrictor response is a hallmark in the progression of obstructive airway diseases. Acetylcholine and 5-hydroxytryptamine (5-HT, serotonin) are the major bronchoconstrictors.
Maryam Keshavarz, Heike Schwarz, Petra Hartmann, Silke Wiegand, Melanie Skill, Mike Althaus, Wolfgang Kummer, Wolfgang Kummer, Gabriela Krasteva-Christ, Gabriela Krasteva-Christ   +9 more
doaj   +1 more source

Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways

Respiratory Research, 2023
Introduction The standard therapy for bronchial asthma consists of combinations of acute (short-acting ß2-sympathomimetics) and, depending on the severity of disease, additional long-term treatment (including inhaled glucocorticoids, long-acting ß2 ...
Paulina Hempel, Virag Klein, Anna Michely, Svenja Böll, Annette D. Rieg, Jan Spillner, Till Braunschweig, Saskia von Stillfried, Norbert Wagner, Christian Martin, Klaus Tenbrock, Eva Verjans   +11 more
doaj   +1 more source

In Search of Synergistic Insect Repellents: Modeling of Muscarinic GPCR Interactions with Classical and Bitopic Photoactive Ligands

Molecules, 2022
Insect vector-borne diseases pose serious health problems, so there is a high demand for efficient molecules that could reduce transmission. Using molecular docking and molecular dynamics (MD) simulation, we studied a series of compounds acting on human ...
Beata Niklas, Bruno Lapied, Wieslaw Nowak   +2 more
doaj   +1 more source

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse

Respiratory Research, 2006
Background It has been proposed that serotonin (5-HT)-mediated constriction of the murine trachea is largely dependent on acetylcholine (ACh) released from the epithelium.
Koepsell Hermann, Wess Jürgen, Schinkel Alfred H, Wessler Ignatz, Akinci Sibel, Wiegand Silke, Kummer Wolfgang, Haberberger Rainer V, Lips Katrin S   +8 more
doaj   +1 more source

Investigation and toxin identification of a poisoning incident caused by Gymnopilus dilepis in Yunnan Province

Zhongguo shipin weisheng zazhi
ObjectiveTo provide reference for the disposition and clinical treatment of poisoning incidents， rapid toxin screening and the clinical symptoms and treatment of a case of Gymnopilus dilepis poisoning were conducted and discussed.MethodsUltra-high ...
CHEN Rumei, HUANG Xiaoqin, RUAN Yanming, SUN Mingyue, CHEN Min, LIN Ji   +5 more
doaj   +1 more source

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj   +1 more source

Simultaneous Determination of Multi-Class Mushroom Toxins in Mushroom and Biological Liquid Samples Using LC-MS/MS

Separations
A comprehensive analytical method based on liquid chromatography–tandem mass spectrometry (LC-MS/MS) was developed for the simultaneous detection of 12 mushroom toxins (ibotenic acid, muscimol, muscarine, β-amanitin, α-amanitin, desoxoviroidin, γ ...
Junjia Lu, Jing Zhang, Haijiao Li, Chengye Sun   +3 more
doaj   +1 more source

Host‐Guest Chemistry of Truncated Tetrahedral Imine Cages with Ammonium Ions

ChemistryOpen, 2020
Three shape‐persistent [4+4] imine cages with truncated tetrahedral geometry with different window sizes were studied as hosts for the encapsulation of tetra‐n‐alkylammonium salts of various bulkiness.
Jochen C. Lauer, Ziwei Pang, Paul Janßen, Dr. Frank Rominger, Tobias Kirschbaum, Prof. Dr. Marcus Elstner, Prof. Dr. Michael Mastalerz   +6 more
doaj   +1 more source

OSWALD SCHMIEDEBERG –THE “FATHER” OF EXPERIMENTAL PHARMACOLOGY [PDF]

Research Results in Pharmacology, 2017
Biography. Oswald Schmiedeberg (1838-1921) was a son of a bailiff and a maid of honour, the eldest of the six children in the family. He was born and educated in the Russian Empire. Scientific activity. All his life he was completely devoted to science,
Mikhail Pokrovskii, Tatyana Avtina, Elena Zakharova, Yulia Belousova   +3 more
doaj   +3 more sources

Acetylcholine regulation of GnRH neuronal activity: A circuit in the medial septum

Frontiers in Endocrinology, 2023
In vertebrates, gonadotropin-releasing hormone (GnRH)-secreting neurons control fertility by regulating gonadotrophs in the anterior pituitary. While it is known that acetylcholine (ACh) influences GnRH secretion, whether the effect is direct or indirect,
David M. Shostak, Stephanie Constantin, Jill Flannery, Susan Wray   +3 more
doaj   +1 more source