Results 51 to 60 of about 2,758 (169)

Dissimilar Reactions and Enzymes for Psilocybin Biosynthesis in Inocybe and Psilocybe Mushrooms

open access: yesAngewandte Chemie International Edition, Volume 64, Issue 46, November 10, 2025.
Mushrooms have learned twice independently how to make the iconic magic mushroom natural product psilocybin. This article introduces the enzymes of the second pathway, found in a fiber cap mushroom. Curiously, the two pathways do not share any reaction, nor do the enzymes show a close relationship, but both pathways proceed via 4‐hydroxytryptamine as a
Tim Schäfer   +3 more
wiley   +1 more source

Nicotinic Acetylcholine Receptor Pathways in Cancer: From Psychiatric Clues to Therapeutic Opportunities

open access: yesCancer Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background The prevalence of cancer poses significant challenges to treatment, largely because of drug resistance along with other side effects. Current studies have been investigating the growth factors more than other biologic tumor features, such as neurobiologic features.
Mohammad Hossein Azadi   +3 more
wiley   +1 more source

Muscarinic receptor oligomerization [PDF]

open access: yesNeuropharmacology, 2018
G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins. However, in recent years, a growing number of studies has supported the hypothesis that these receptors can interact to form dimers and higher order oligomers
Marsango, Sara   +3 more
openaire   +2 more sources

Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer

open access: yesSensors, 2009
Harnessing the potential of cells as complex biosensors promises the potential to create sensitive and selective detectors for discrimination of biodefense agents.
John Wikswo   +6 more
doaj   +1 more source

Neurochemical architecture of the central complex related to its function in the control of grasshopper acoustic communication. [PDF]

open access: yesPLoS ONE, 2011
The central complex selects and coordinates the species- and situation-specific song production in acoustically communicating grasshoppers. Control of sound production is mediated by several neurotransmitters and modulators, their receptors and ...
Michael Kunst   +3 more
doaj   +1 more source

A Critical Overview of Common Foodborne Toxicants and Methods for Their Reliable Detection

open access: yesFood Frontiers, Volume 6, Issue 4, Page 1658-1700, July 2025.
ABSTRACT Food is an essential commodity for human health. However, toxicants such as mycotoxins, heavy metals, acrylamide, and pesticides can be present in food either naturally or through processing, packaging, or some anthropogenic activities. A thorough review of carefully selected studies revealed that climate change and pandemics have led to an ...
Betty Bowe Acquah   +1 more
wiley   +1 more source

Serotonin increases cilia-driven particle transport via an acetylcholine-independent pathway in the mouse trachea. [PDF]

open access: yesPLoS ONE, 2009
BACKGROUND: Mucociliary clearance in the airways is driven by the coordinated beating of ciliated cells. Classical neuromediators such as noradrenalin and acetylcholine increase ciliary beat frequency and thus cilia-driven transport.
Peter König   +3 more
doaj   +1 more source

Synthesis of [3H]muscimol

open access: yesJournal of Labelled Compounds and Radiopharmaceuticals, Volume 68, Issue 9-10, July-August 2025.
A novel synthetic approach for the preparation of [3H]muscimol (48.3 Ci/mmol, 1.8 TBq/mmol) based on the reduction of a suitably protected amide precursor using in situ generated tritioborane (BT3·THF) is reported. The method avoids the use of bulk tritiated water employed in established synthetic protocols and enables safe, reliable, and efficient ...
Michal Kriegelstein, Aleš Marek
wiley   +1 more source

Aqueous semisynthesis of C-glycoside glycamines from agarose

open access: yesBeilstein Journal of Organic Chemistry, 2017
Agarose was herein employed as starting material to produce primary, secondary and tertiary C-glycoside glycamines, including mono- and disaccharide structures.
Juliana C. Cunico Dallagnol   +5 more
doaj   +1 more source

Evaluation of 0.1% and 1% atropine eyedrops in cats: A comparative study of tolerance, stability, and efficacy

open access: yesVeterinary Ophthalmology, Volume 28, Issue 4, Page 714-721, July 2025.
Abstract Objective Investigate the tolerance, stability, and efficacy of topical 0.1% and 1% atropine in cats. Procedures Six cats underwent two trials separated by a 2‐week washout period. One drop of artificial tears was placed in one randomly selected eye (control), and one drop of either 0.1% atropine (Trial I) or 1% atropine (Trial II) was placed ...
Karin W. Handel   +4 more
wiley   +1 more source

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