Results 61 to 70 of about 2,758 (169)

Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins With Light

Neurogastroenterology &Motility, Volume 37, Issue 6, June 2025.
Optogenetic stimulation enables direct and selective stimulation of smooth muscle cells and thus provides a new opportunity to restore gastric contractility in cases of gastroparesis. Herein, we demonstrate that hOPN5 is a new and effective tool acting via Gq signaling and is thus complementary to light‐induced membrane depolarization with ...
David Zipf, Markus Vogt, Udhayabhaskar Sathyanarayanan, Ahmed Wagdi, Johannes Riebeling, Robert Patejdl, Tobias Bruegmann   +6 more
wiley   +1 more source

Spatial repellency and molecular docking studies on thymol, oleic acid and naphthalene against the urban malaria vector, Anopheles stephensi (Diptera: Culicidae)

Journal of Basic and Applied Zoology
Background Anopheles stephensi (Diptera: Culicidae) is a primary urban malaria vector in India and neighbouring countries. Spatial repellents are a novel tool for personal protection against bites and curbing malaria transmission.
Neetu Kachhwaha, Rakesh Kumar Samantaray, Nagendra Singh Chauhan, Sanyam Nimoria, Sushmita Swain, Devi Shankar Suman   +5 more
doaj   +1 more source

Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases

Orthopaedic Surgery, Volume 17, Issue 6, Page 1561-1576, June 2025.
Due to the close connection between the autonomic nervous system and skeletal system, large amounts of evidence have shown that neuromodulation plays a crucial role in regulating bone metabolism. Clinically, neuromodulation has exhibited promising therapeutic effects in treating joint disorders by significantly reducing inflammation and clinical scores.
Ruihao Xia, Hongjun Peng, Xishan Zhu, Wangdui Suolang, Steve T. L. Pambayi, Xiao Yang, Yi Zeng, Bin Shen   +7 more
wiley   +1 more source

Pre-synaptic Muscarinic Excitation Enhances the Discrimination of Looming Stimuli in a Collision-Detection Neuron

Cell Reports, 2018
Summary: Visual neurons that track objects on a collision course are often finely tuned to their target stimuli because this is critical for survival. The presynaptic neural networks converging on these neurons and their role in tuning them remain poorly
Ying Zhu, Richard B. Dewell, Hongxia Wang, Fabrizio Gabbiani   +3 more
doaj   +1 more source

Influence of Acupuncture at Zusanli point on Function of 5-HT and M Recepter in Rat's Brain and Spleen

针刺研究, 1994
5-HT and muscarine (M) recepters total binding capacities (Rt) in different brain areas and spleen were determined using recepter radioligand binding assay (RLBA) after needling zusanli of rats.
莫启忠, 宫斌, 方军, 李建萍, 黄巨涛, 陈坤华, 匡兴伟, 王菊美   +7 more
doaj   +2 more sources

Biodiversity2Drugs—Renaissance of exploring nature‐derived peptides for GPCR ligand discovery

British Journal of Pharmacology, Volume 182, Issue 16, Page 3691-3694, August 2025.
Christian W. Gruber, Isabel Beets, Pierre‐Luc Boudreault, Vanderlan da S. Bolzani, Jens Carlsson, Pedro A. Fernandes, Michael Freissmuth, Nicolas Gilles, Ulf Göransson, Alexander S. Hauser, Christian Heinis, Jeroen Kool, William D. Lubell, Maria Vittoria Modica, Jana Selent, Jan Tytgat, Eivind A. B. Undheim, The Biodiversity2Drugs Consortium, Christian W. Gruber, Michael Freissmuth, Nicolas Gilles, Marion Chaigneau, Xavier Iturrioz, Pascal Kessler, Philippe Robin, Isabel Beets, Eivind A. B. Undheim, Jeroen Kool, Rob Leurs, Henry Vischer, Jan Tytgat, Steve Peigneur, Kathleen Carleer, Vanderlan da S. Bolzani, Ana Leticia Piros, William Lubell, Pierre‐Luc Boudreault, Alexander S. Hauser, Luuk R. Hoegen Dijkhof, Teemu K. E. Rönkkö, Maria Vittoria Modica, Serena Leone, Giovanna Ponte, Pedro Fernandes, Maria Joao Ramos, Jana Selent, Elizaveta Korchevaya, Tomasz Stepniewski, Jens Carlsson, Israel Cabeza de Vaca, Ulf Göransson, Sunithi Gunasekera, Erik Jacobsson, Christian Heinis, Tao Che, Maurice R. Elphick, Peter J. McCormick, Samuel Robinson, Helena Safavi‐Hemami, Roderich D. Süssmuth, Axel Touchard, Wilfred A. van der Donk, Denise Wootten, Julius Hermes, Johannes Schneider, Ana Leticia Pires, Marin Matic, António J. M. Ribeiro, João Sousa, Joana Ribeiro da Silva, Lauri Urvas, Arun Shukla   +71 more
wiley   +1 more source

The Pharmacological Effects of Daikenchuto, a Traditional Herbal Medicine, on Delayed Gastrointestinal Transit in Rat Postoperative Ileus

Journal of Pharmacological Sciences, 2007
The effect of Daikenchuto, a traditional herbal medicine, on gastrointestinal hypoperistalsis in postoperative ileus (POI) was investigated. POI was induced by laparotomy with manipulation of the gastrointestine under anesthesia, and gastrointestinal ...
Yohei Tokita, Mitsutoshi Yuzurihara, Masaru Sakaguchi, Kazuko Satoh, Yoshio Kase   +4 more
doaj   +1 more source

THE STORY OF MUSCARINE [PDF]

Journal of Pharmacy and Pharmacology, 1958
K, BOWDEN, G A, MOGEY
openaire   +2 more sources

Cholinesterase activity determines the action potential-dependent increase in glycine receptor-mediated inhibitory synaptic transmission in the substantia gelatinosa of the spinal trigeminal nucleus of the rat

Journal of Pharmacological Sciences
Acetylcholine-mediated modulation of pain-associated behaviors has been progressively well described. The mechanisms of cholinergic antinociception have been reported to involve the activation of nAChRs or mAChRs modulating GABAergic and/or glycinergic ...
Masahito Kawamura, Jr., Eiji Masaki, Fusao Kato   +2 more
doaj   +1 more source

Nicotine-evoked cytosolic Ca2+ increase and cell depolarization in capillary endothelial cells of the bovine adrenal medulla

Biological Research, 2009
Endothelial cells are directly involved in many functions of the cardiovascular system by regulating blood flow and blood pressure through Ca2+ dependent exocitosis of vasoactive compounds.
RAÚL VINET, MAGDALENA CORTÉS, MARIO LUXORO, MARCO A DELPIANO   +3 more
doaj