Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation† [PDF]
Angewandte Chemie - International Edition, 2020 The fly agaric, Amanita muscaria, is widely known for its content of the psychoactive metabolites ibotenic acid and muscimol. However, their biosynthetic pathway and the respective enzymes are entirely unknown.
Sebastian Obermaier, Michael Müller
exaly +8 more sources
Acute Amanita muscaria Toxicity: A Literature Review and Two Case Reports in Elderly Spouses Following Home Preparation [PDF]
ToxinsAmanita muscaria (L.) Lam., commonly known as fly agaric, remains an uncommon yet clinically important cause of acute mushroom intoxication. Although typically associated with mild to moderate neuropsychiatric disturbances, the mushroom’s toxic profile ...
Stanila Stoeva-Grigorova +5 more
doaj +2 more sources
Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats. [PDF]
PLoS ONE, 2013 AIMS: To investigate the therapeutic effects and acting mechanism of a combination of Chinese herb active components, i.e., a combination of baicalin, jasminoidin and cholic acid (CBJC) on Alzheimer's disease (AD).
Junying Zhang +6 more
doaj +2 more sources
Effects of Methanol Extract of Uncariae Ramulus et Uncus on Ibotenic Acid-Induced Amnesia in the Rat
Journal of Pharmacological Sciences, 2004 In the present study, we investigated the effects of Uncariae Ramulus et Uncus (UR) on learning and memory in the Morris water maze task and the central cholinergic system of rats with excitotoxic medial septum (MS) lesion.
Ji Hyun Kim +7 more
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Emerging Risks of Amanita Muscaria: Case Reports on Increasing Consumption and Health Risks [PDF]
Acta Medica LituanicaIntroduction: The increasing popularity of Amanita muscaria, driven by its hallucinogenic properties, has raised significant public health concerns, particularly as it remains largely unregulated across most European Union countries.
Emilija Savickaitė +1 more
doaj +2 more sources
Fatal poisoning of Old Polish ducks with Amanita muscaria [PDF]
BMC Veterinary ResearchBackground Amanita muscaria (fly agaric) is a poisonous mushroom containing ibotenic acid (IBA) and muscimol (MUS), two neuroactive alkaloids capable of causing severe or fatal intoxication.
Dagmara Stępień-Pyśniak +6 more
doaj +2 more sources
Composition of ibotenic acid-induced calcifications in rat substantia nigra.
Brain Research, 1998 Agonists of the excitatory neurotransmitter glutamate have neurotoxic properties and are, therefore, frequently used to place locally circumscript brain lesions.
Herrmann G, Stünitz H, Nitsch C
core +4 more sources
Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors
European Journal of Pharmacology, 1998 We have studied the effects of the enantiomers of 2-amino-3-(3-hydroxyisoxazol-5-yl)propionic acid (homoibotenic acid, HIBO) and analogues substituted with a methyl, bromo or butyl group in the four position of the ring at cloned metabotropic glutamate ...
Bräuner-Osborne, Hans +2 more
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Morphology, multilocus phylogeny, and toxin analysis reveal two new species of Amanita section Amanita (Amanitaceae) from China [PDF]
MycoKeysGlobally, many species of Amanita sect. Amanita (Amanitaceae, Agaricales) cause poisoning after consumption. Amanita flavomelleiceps sp. nov. and Amanita parvisychnopyramis sp. nov., two new species of A.
Yu-Ting Su +5 more
doaj +4 more sources
Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain [PDF]
, 2013 Brain damage caused by an acute injury depends on the initial severity of the injury and the time elapsed after the injury. To determine whether these two variables activate common mechanisms, we compared the response of the rat medial septum to insult ...
Andrés, N. +6 more
core +7 more sources