Results 21 to 30 of about 8,003 (176)

A Human Microglial Cell Line Expresses γ-Aminobutyric Acid (GABA) Receptors and Responds to GABA and Muscimol by Increasing Production of IL-8

Neuroglia, 2023
Gamma-aminobutyric acid (GABA) is an essential neurotransmitter and an important regulator of neuroinflammation and disease. Microglia are important immune cells in the brain that express GABA receptors (GABAR) and respond to both GABA and GABAR agonists,
Ashley Wagner, Zhimin Yan, Marianna Kulka   +2 more
doaj   +1 more source

The role of substantia nigra pars reticulata in modulating clonic seizures is determined by testosterone levels during the immediate postnatal period

Neurobiology of Disease, 2007
GABAergic activation of substantia nigra pars reticulata (SNR) at postnatal day (PN) 15 has sex-specific features on seizure control in vivo and electrophysiological responses in vitro.
Filippo S. Giorgi, Jana Velíšková, Ondřej Chudomel, Andreas Kyrozis, Solomon L. Moshé   +4 more
doaj   +1 more source

GABA Receptor Agonists Protect From Excitotoxic Damage Induced by AMPA in Oligodendrocytes

Frontiers in Pharmacology, 2022
Oligodendrocytes are the myelin forming cells of the central nervous system, and their vulnerability to excitotoxicity induced by glutamate contributes to the pathogenesis of neurological disorders including brain ischemia and neurodegenerative diseases,
Laura Bayón-Cordero, Laura Bayón-Cordero, Laura Bayón-Cordero, Blanca Isabel Ochoa-Bueno, Blanca Isabel Ochoa-Bueno, Blanca Isabel Ochoa-Bueno, Asier Ruiz, Asier Ruiz, Asier Ruiz, Marina Ozalla, Carlos Matute, Carlos Matute, Carlos Matute, María Victoria Sánchez-Gómez, María Victoria Sánchez-Gómez, María Victoria Sánchez-Gómez   +15 more
doaj   +1 more source

A Study on the Effect of Intracuneiformis Nucleus Microinjection of GABAA Receptor Agonist and Antagonist on Antinociceptive Effects of Morphine by Formalin Test in Rat [PDF]

Journal of Kerman University of Medical Sciences, 2005
In the present study, the effects of intracuneiformis nucleus microinjection of gamma-aminobutyric acidA (GABAA) receptor agonist and antagonist on antinociception inducced by morphine were investigated with formalin test in rat. Intracuneiformis nucleus
M Rezvanipour, T Safari, M Abasnejad
doaj  

In vitro and in vivo effects of Amanita muscaria tincture on the a. basilaris contractility and on a rotenone-induced model of Parkinson’s disease [PDF]

Pharmacia
Amanita muscaria is a well-known mushroom containing the GABAA receptor agonist muscimol, a compound of growing interest due to its potential neuroprotective properties. The present study investigated the in vivo neuroprotective effects of an A. muscaria
Magdalena Kondeva-Burdina, Georgi Popov, Aleksandar Shkondrov, Boris Kadinov, Vasil Manov, Ilina Krasteva   +5 more
doaj   +3 more sources

Simultaneous intrathecal injection of muscimol and endomorphin‐1 alleviates neuropathic pain in rat model of spinal cord injury

Brain and Behavior, 2020
Introduction Due to side effects of medications used for chronic pain, combination therapy seems to be an appropriate solution for alleviation of chronic pain and reducing the side effects.
Marjan Hosseini, Zohreh Karami, Mahmood Yousefifard, Atousa Janzadeh, Elham Zamani, Farinaz Nasirinezhad   +5 more
doaj   +1 more source

Object Recognition Memory: Distinct Yet Complementary Roles of the Mouse CA1 and Perirhinal Cortex

Frontiers in Molecular Neuroscience, 2020
While the essential contribution of the hippocampus to spatial memory is well established, object recognition memory has been traditionally attributed to the perirhinal cortex (PRh).
David A. Cinalli Jr., David A. Cinalli Jr., Sarah J. Cohen, Sarah J. Cohen, Kathleen Guthrie, Kathleen Guthrie, Robert W. Stackman Jr., Robert W. Stackman Jr., Robert W. Stackman Jr., Robert W. Stackman Jr.   +9 more
doaj   +1 more source

Impulsive and compulsive behaviors can be induced by opposite GABAergic dysfunctions inside the primate ventral pallidum

Frontiers in Systems Neuroscience, 2022
Introduction: The ventral pallidum (VP) is central in the limbic Basal Ganglia circuit, controlling both appetitive (approach) and aversive (avoidance) motivated behaviors.
Yosuke Saga, Laurent Galineau, Léon Tremblay, Léon Tremblay   +3 more
doaj   +1 more source

Pre-Training Reversible Inactivation of the Basal Amygdala (BA) Disrupts Contextual, but Not Auditory, Fear Conditioning, in Rats. [PDF]

PLoS ONE, 2015
The basolateral amygdala complex (BLA), including the lateral (LA), basal (BA) and accessory basal (AB) nuclei, is involved in acquisition of contextual and auditory fear conditioning.
Elisa Mari Akagi Jordão, Barbara Kazue Amaral Onishi, Gilberto Fernando Xavier   +2 more
doaj   +1 more source

Synthesis of [³H]muscimol

Journal of Labelled Compounds and Radiopharmaceuticals
ABSTRACTMuscimol, a potent GABAA receptor agonist and psychoactive alkaloid found in Amanita mushrooms, is widely used as a tool compound in neurochemical research. Despite its importance, synthetic access to [3H]muscimol of high specific activity has remained limited due to the challenges associated with conventional labeling strategies.
Michal Kriegelstein, Aleš Marek
openaire   +4 more sources