Results 191 to 200 of about 10,541 (227)

The importance of FMDV localisation in lymphoid tissue

Veterinary Immunology and Immunopathology, 2012
Foot-and-mouth disease virus, a highly contagious pathogen that can cause lameness, low weight and decreased milk production, is a scourge of agricultural livestock around the world. Although the acute phase of infection is rarely fatal, infection may persist in animals that have apparently recovered, creating a viral reservoir that some fear could ...
N D, Juleff, F F, Maree, R, Waters, R G, Bengis, B, Charleston   +4 more
openaire   +2 more sources

KIF5B-mediated internalization of FMDV promotes virus infection

Virologica Sinica
Foot-and-mouth disease (FMD) is a highly contagious and economically important disease, which is caused by the FMD virus (FMDV). Although the cell receptor for FMDV has been identified, the specific mechanism of FMDV internalization after infection remains unknown.
Haixue Zheng, Weijun Cao
exaly   +3 more sources

Recombinant pseudorabies virus expressing P12A and 3C of FMDV can partially protect piglets against FMDV challenge

Research in Veterinary Science, 2011
One of the crucial factors for evaluation of an effective genetically engineered vaccine is whether susceptible animals are protected from virus challenge after vaccination. In this study, a recombinant pseudorabies virus (PRV-P12A3C) that expressed capsid precursor polypeptide P12A and nonstructural protein 3C of foot-and-mouth disease virus (FMDV ...
Keshan, Zhang, Jiong, Huang, Qingang, Wang, Yannan, He, Zhuofei, Xu, Min, Xiang, Bin, Wu, Huanchun, Chen   +7 more
openaire   +2 more sources

Immune responses and protection against foot-and-mouth disease virus (FMDV) challenge in swine vaccinated with adenovirus-FMDV constructs

Vaccine, 2001
A replication-defective adenovirus 5 encoding foot-and-mouth disease virus (FMDV) capsid and 3C proteinase coding regions (Ad5-FMDV3CWT) was used to vaccinate swine. A single inoculation utilizing 1 x 10(8) plaque forming units (pfu) or an inoculation of 1 x 10(8) followed by a boost of 5 x 10(8) pfu Ad5-FMDV3CWT were tested, along with an inoculation ...
G A, Mayr, V, O'Donnell, J, Chinsangaram, P W, Mason, M J, Grubman   +4 more
openaire   +2 more sources

Detection of FMDV RNA amplified by the polymerase chain reaction (PCR)

Journal of Virological Methods, 1992
Molecular detection of foot-and-mouth disease virus (FMDV) using the polymerase chain reaction (PCR) is a rapid and accurate method. In this study we present PCR for the detection of FMDV RNA in infected BHK cells. Using PCR and two primers selected from the RNA polymerase gene, a conserved sequence in all types and subtypes of FMDV, we were able to ...
Yechiel Becker, Hagai Yadin
exaly   +3 more sources

Translation and Replication of FMDV RNA

2005
Foot-and-mouth disease virus (FMDV) RNA is infectious. After delivery of the RNA (about 8.3 kb) into the cytoplasm of a cell, the RNA must initially be translated to produce the viral proteins required for RNA replication and for the packaging of the RNA into new virions. Subsequently there has to be a switch in the function of the RNA; translation has
openaire   +2 more sources

Transcriptomic analysis of porcine PBMCs in response to FMDV infection

Acta Tropica, 2017
Foot-and-mouth disease (FMD) is a significant zoonotic infectious disease. It has an important economic impact throughout the world. As well, it is a considerable threat to food security. At present, the molecular mechanism of FMDV infection is not clear to a large extent. Innate immune response is the first line of defense against infectious diseases.
Fu-Rong, Zhao, Yin-Li, Xie, Ze-Zhong, Liu, Jun-Jun, Shao, Shi-Fang, Li, Yong-Guang, Zhang, Hui-Yun, Chang   +6 more
openaire   +2 more sources

Vaccines prepared from chimeras of foot-and-mouth disease virus (FMDV) induce neutralizing antibodies and protective immunity to multiple serotypes of FMDV

Journal of Virology, 1994
The G-H loop of VP1 (residues 132 to 159) of foot-and-mouth disease virus (FMDV) is a prominent feature on the virion surface and has an important role in vaccine efficacy, generation of antigenic variants, and cell binding. Using an infectious cDNA of FMDV, we have constructed serotype A viruses in which the G-H loop has been substituted with the ...
E, Rieder, B, Baxt, J, Lubroth, P W, Mason   +3 more
openaire   +2 more sources

Biochemical characterization of FMDV A10 and A22 subtypes by PAGE and IEF

Comparative Immunology, Microbiology and Infectious Diseases, 1997
Both polyacrylamide gel electrophoresis (PAGE) and iso-electric focusing (IEF) have been standardized using the sucrose density gradient purified 146S particles of FMD virus subtypes A10 and A22. Differences in the molecular weights of structural proteins (VP1, VP2 and VP3 of two subtypes (A10 and A22) of FMDV have been revealed in PAGE but no ...
S, Nandi, V V, Suryanarayana, N, Banumathi, A K, Sen   +3 more
openaire   +2 more sources

Some aspects of FMDV-production in growing cells and a closed system for concentration of FMDV by polyethylene glycol.

Developments in biological standardization, 1979
Different commercially available peptone preparations, all derived by enzymatic digestion of meat, were tested for their ability to replace the individual amino acids and polyethylene glycol (PEG)-treated serum in BHK suspended cell culture growth medium.
openaire   +1 more source