Increased FNDC5 is associated with insulin resistance in high fat-fed mice
Physiological Reports, 2017 FNDC5/irisin, has recently been identified as a novel protein that stimulates the "browning" of white adipose by inducing thermogenesis via increased uncoupling protein 1 (UCP1). We tested the hypothesis that high fat diet-induced prediabetic mice would exhibit increased FNDC5 and this effect would be attenuated by chronic exercise.
Caleb W. Grote +5 more
openaire +3 more sources
Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway [PDF]
Cell Metabolism, 2013 Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Here we show that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and ...
Michael E. Greenberg +8 more
openaire +3 more sources
The stormy relationship between fats and the development of type 2 diabetes mellitus: Updated. Part 2 [PDF]
, 2017 En esta parte de la revisión se describe la relación funcional entre el metabolismo de los lípidos y los hidratos de carbono y su interdependencia, desde el ciclo glucosa-ácido grasos y la hipótesis portal de la insulinorresistencia a los nuevos ...
Costa Gil, José Esteban +1 more
core +2 more sources
Physiological Reports, Volume 13, Issue 12, June 2025.Abstract Age‐ and disease‐related metabolic responses to prolonged passive heat exposure are poorly understood. We evaluated serum irisin and betatrophin responses to 9 h of passive heat exposure (40°C, 9% relative humidity) in 19 young adults (19–31 years) and 37 older adults (61–78 years), including those with hypertension (HTN) and type 2 diabetes ...
Joel M. Garrett +7 more
wiley +1 more source
La expresión génica de FNDC5 en distintos tejidos, y los niveles circulantes de irisina, están modificados por la dieta y las condiciones hormonales [PDF]
, 2016 ResumenXunta de Galicia; EM2013/011Instituto de Salud Carlos III; PI13 ...
Cordido, Fernando +4 more
core
The universal role of adaptive transcription in health and disease
The FEBS Journal, Volume 292, Issue 10, Page 2479-2505, May 2025.Adaptive transcription via molecules such as CREB, MEF2, SRF, AP1, Nr4a1, and Egr1 constitutes a universal mechanism for directed cell state transitions in health and disease. These molecules are involved in physiological adaptation processes, pathological maladaptations, curative adaptations, and development of resistance to treatment.
Thomas Lissek
wiley +1 more source
The the role of eight weeks of combined high-intensity interval training in modulating intrahepatic FNDC5 protein and irisin levels in male rats with non-alcoholic steatohepatitis [PDF]
Jorjani Biomedicine Journal, 2023 Background: Non-alcoholic steatohepatitis (NASH) is one of the prevalent metabolic diseases, and knowing its treatment methods is very important.
rahil Shahriari +3 more
doaj
Effects of Qingyangshen glycosides on neuroplasticity in a mouse model of social defeat
Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 581-594, April 2025.Summary of the experimental effects of qingyangshen glycosides on neuroplasticity in mice model of social defeat. Abstract Background Qingyangshen (Cynanchum otophyllum C.K. Schneid) is a folk drug for treating depression and other mental disorders induced by social defeat stress.
Jingru Wang +6 more
wiley +1 more source
Clinical Interventions in Aging, 2021 Yijie Liu,1,2,* Chaoyang Guo,1,* Shuting Liu,1 Shuai Zhang,3 Yun Mao,4 Lei Fang1 1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 2Institute of Rehabilitation ...
Liu Y +5 more
doaj
Irisin and Fibronectin Type III Domain-Containing 5 Responses to Exercise in Different Environmental Conditions [PDF]
, 2017 International Journal of Exercise Science 10(5): 666-680, 2017. Fibronectin type III domain-containing 5 (FNDC5) is a skeletal muscle membrane-bound precursor to the myokine irisin.
D. Taylor La Salle +7 more
core +2 more sources