Results 11 to 20 of about 221,217 (305)
Foam Cells Control Mycobacterium tuberculosis Infection [PDF]
Frontiers in Microbiology, 2020 Mycobacterium tuberculosis (Mtb) infects macrophages and macrophage-derived foam cells, a hallmark of granulomata in tuberculous lesions. We analyzed the effects of lipid accumulation in human primary macrophages and quantified strong triglyceride and ...
Pooja Agarwal +7 more
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Stigmasterol attenuates atherosclerosis by inhibiting inflammatory signaling and foam cell formation [PDF]
iMetaOmicsFoam cells derived from macrophages and smooth muscle cells (SMCs) play a pivotal role in the progression of atherosclerosis. While phytosterols (PS) have demonstrated cholesterol‐lowering and anti‐inflammatory properties, their impact on foam cells ...
Baiyi Lu +10 more
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Biomolecules, 2023 Elevated levels of saturated very long-chain fatty acids (VLCFAs) in cell membranes and secreted lipoparticles have been associated with neurotoxicity and, therefore, require tight regulation.
Andrea Villoria-González +11 more
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Foam Cell Macrophages in Tuberculosis [PDF]
Frontiers in Immunology, 2021 Mycobacterium tuberculosis infects primarily macrophages in the lungs. Infected macrophages are surrounded by other immune cells in well organised structures called granulomata. As part of the response to TB, a type of macrophage loaded with lipid droplets arises which we call Foam cell macrophages. They are macrophages filled with lipid laden droplets,
Pooja Agarwal +3 more
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Modified Lipoproteins Induce Arterial Wall Inflammation During Atherogenesis
Frontiers in Cardiovascular Medicine, 2022 Circulating apolipoprotein B-containing lipoproteins, notably the low-density lipoproteins, enter the inner layer of the arterial wall, the intima, where a fraction of them is retained and modified by proteases, lipases, and oxidizing agents and enzymes.
Martina B. Lorey +4 more
doaj +1 more source
Drug screen identifies verteporfin as a regulator of lipid metabolism in macrophage foam cells
Scientific Reports, 2023 Arterial macrophage foam cells are filled with cholesterol ester (CE) stored in cytosolic lipid droplets (LDs). Foam cells are central players in progression of atherosclerosis as regulators of lipid metabolism and inflammation, two major driving forces ...
Nicholas Hoeffner +2 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Introduction: Atherosclerosis is the main cause of many cardiovascular diseases and contributes to morbidity and mortality worldwide. The formation of macrophage-derived foam cells plays a critical role in the early stage of atherosclerosis pathogenesis.
Cheng Zhang +12 more
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Frontiers in Cardiovascular Medicine, 2022 IntroductionAtherosclerotic cardiovascular disease is the leading cause of death worldwide. The Edgeworthia gardneri (Wall.) Meisn is a Tibetan medicine commonly used to prepare herbal tea to alleviate the local people's metabolic diseases.
Le Tang +13 more
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Comparative study of several different modeling methods for clossed- cell metal foam
Journal of Aeronautical Materials, 2020 In order to study the uniaxial compression properties of closed-cell metal foam, three different modeling methods were used in this paper to establish 2D random cell, 3D Kelvin and 3D voronoi metal foam model.
GUO Yazhou +4 more
doaj +1 more source
Foam Cell Specific LXRα Ligand [PDF]
PLoS ONE, 2013 The liver X receptor α (LXRα) is a ligand-dependent nuclear receptor and the major regulator of reverse cholesterol transport in macrophages. This makes it an interesting target for mechanistic study and treatment of atherosclerosis.We optimized a promising stilbenoid structure (STX4) in order to reach nanomolar effective concentrations in LXRα ...
Feldmann, Radmila +8 more
openaire +5 more sources