Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells [PDF]
Advanced ScienceArterial Vascular smooth muscle cells (VSMCs) play a central role in the onset and progression of atherosclerosis. Upon exposure to pathological stimuli, they can take on alternative phenotypes that, among others, have been described as macrophage like ...
Pamela Swiatlowska +9 more
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Drug screen identifies verteporfin as a regulator of lipid metabolism in macrophage foam cells [PDF]
Scientific Reports, 2023 Arterial macrophage foam cells are filled with cholesterol ester (CE) stored in cytosolic lipid droplets (LDs). Foam cells are central players in progression of atherosclerosis as regulators of lipid metabolism and inflammation, two major driving forces ...
Nicholas Hoeffner +2 more
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Foam cells: tracing the diverse cellular origins and their linked signaling pathways [PDF]
Journal of Translational MedicineFoam cells play a crucial role in the formation and progression of atherosclerotic plaque. In addition to classical monocytes and vascular smooth muscle cells (VSMCs), foam cells can also originate from dendritic cells, endothelial cells, and stem cells.
Xinyun Jiao +6 more
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Increased atherosclerosis and expression of inflammarafts in macrophage foam cells in AIBP-deficient mice. [PDF]
Scientific ReportsAtherosclerotic lesions comprise different populations of macrophages, including lipid-laden macrophage foam cells and non-foamy, inflammatory macrophages, which play distinct roles in disease progression.
Shenglin Li +9 more
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Foam Cells Control Mycobacterium tuberculosis Infection [PDF]
Frontiers in Microbiology, 2020 Mycobacterium tuberculosis (Mtb) infects macrophages and macrophage-derived foam cells, a hallmark of granulomata in tuberculous lesions. We analyzed the effects of lipid accumulation in human primary macrophages and quantified strong triglyceride and ...
Pooja Agarwal +7 more
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Foam Cell Macrophages in Tuberculosis [PDF]
Frontiers in Immunology, 2021 Mycobacterium tuberculosis infects primarily macrophages in the lungs. Infected macrophages are surrounded by other immune cells in well organised structures called granulomata.
Pooja Agarwal +3 more
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An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in atherosclerosis [PDF]
Frontiers in Cell and Developmental BiologyExcess cholesterol accumulation induces the accumulation of foam cells, eventually accelerating atherosclerosis progress. Historically, the mechanisms of macrophage-derived foam cells have attracted attention because of their central role in plaque ...
Jingjing Guo, Laijing Du
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CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagy [PDF]
Cell Death and DiseaseVascular smooth muscle cells (VSMCs) are a significant source of foam cells in atherosclerosis, but the mechanism involved in the formation of VSMC-derived foam cells remains poorly understood.
Tiegen Huang +6 more
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Lipid accumulation in foam cells drives C1q-dependent synaptic loss and impairs motor function recovery after spinal cord injury [PDF]
Communications BiologyMacrophages play a critical role in the repair process following spinal cord injury (SCI), yet the complex mechanisms underlying their functionality remain poorly understood.
Ying Peng +11 more
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