Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells [PDF]
Advanced ScienceArterial Vascular smooth muscle cells (VSMCs) play a central role in the onset and progression of atherosclerosis. Upon exposure to pathological stimuli, they can take on alternative phenotypes that, among others, have been described as macrophage like ...
Pamela Swiatlowska +9 more
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Drug screen identifies verteporfin as a regulator of lipid metabolism in macrophage foam cells [PDF]
Scientific Reports, 2023 Arterial macrophage foam cells are filled with cholesterol ester (CE) stored in cytosolic lipid droplets (LDs). Foam cells are central players in progression of atherosclerosis as regulators of lipid metabolism and inflammation, two major driving forces ...
Nicholas Hoeffner +2 more
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Frontiers in Cardiovascular Medicine, 2022 Foam cells play a vital role in the initiation and development of atherosclerosis. This review aims to summarize the novel insights into the origins, consequences, and molecular mechanisms of foam cells in atherosclerotic plaques.
Yuzhou Gui +3 more
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Foam cells: tracing the diverse cellular origins and their linked signaling pathways [PDF]
Journal of Translational MedicineFoam cells play a crucial role in the formation and progression of atherosclerotic plaque. In addition to classical monocytes and vascular smooth muscle cells (VSMCs), foam cells can also originate from dendritic cells, endothelial cells, and stem cells.
Xinyun Jiao +6 more
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Increased atherosclerosis and expression of inflammarafts in macrophage foam cells in AIBP-deficient mice. [PDF]
Scientific ReportsAtherosclerotic lesions comprise different populations of macrophages, including lipid-laden macrophage foam cells and non-foamy, inflammatory macrophages, which play distinct roles in disease progression.
Shenglin Li +9 more
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Foam Cells Control Mycobacterium tuberculosis Infection
Frontiers in Microbiology, 2020 Mycobacterium tuberculosis (Mtb) infects macrophages and macrophage-derived foam cells, a hallmark of granulomata in tuberculous lesions. We analyzed the effects of lipid accumulation in human primary macrophages and quantified strong triglyceride and ...
Pooja Agarwal +7 more
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An update on ox-LDL-inducing vascular smooth muscle cell-derived foam cells in atherosclerosis [PDF]
Frontiers in Cell and Developmental BiologyExcess cholesterol accumulation induces the accumulation of foam cells, eventually accelerating atherosclerosis progress. Historically, the mechanisms of macrophage-derived foam cells have attracted attention because of their central role in plaque ...
Jingjing Guo, Laijing Du
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Lipid accumulation in foam cells drives C1q-dependent synaptic loss and impairs motor function recovery after spinal cord injury [PDF]
Communications BiologyMacrophages play a critical role in the repair process following spinal cord injury (SCI), yet the complex mechanisms underlying their functionality remain poorly understood.
Ying Peng +11 more
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Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis [PDF]
International Journal of Molecular Sciences, 2022 Malgorzata Kľoc +2 more
exaly +2 more sources
BBA Advances, 2021 Objective: Probucol is a cholesterol-lowering agent whose ability to prevent atherosclerosis is currently under study. Herein, we investigate the putative mechanism of probucol by observation of changes in cellular cholesterol efflux and lipid droplet ...
Anouar Hafiane, MSc, PhD +5 more
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