Results 11 to 20 of about 66,391 (209)

Preliminary study on the role of miR-16 in progression of coronary atherosclerosis and possible molecular mechanism [PDF]

Zhenduanxue lilun yu shijian, 2021
Objective: To explore the role of microRNA (miRNA, miR) -16 in the development of coronary atheromatous plaques and to study possible mechanism involved in the process.
ZHA Qing, YU Chenxi, LIU Ya, YANG Ling, YE Jiawen, LIU Yan
doaj   +1 more source

Mechanical characteristics and foam filling enhancement mechanism of polymeric periodic hybrid structures under uniaxial compression

Materials & Design, 2023
In this study, two types of polymeric periodic hybrid (PPH) structures with hexagonal and re-entrant cells were proposed and manufactured by 3D printing using polylactic acid (PLA). PVC foam was adopted as filler material.
Ting Liu, Changhai Chen, Yuansheng Cheng
doaj   +1 more source

Smooth Muscle Cell—Macrophage Interactions Leading to Foam Cell Formation in Atherosclerosis: Location, Location, Location

Frontiers in Physiology, 2022
Cholesterol-overloaded cells or “foam cells” in the artery wall are the biochemical hallmark of atherosclerosis, and are responsible for much of the growth, inflammation and susceptibility to rupture of atherosclerotic lesions.
Pinhao Xiang, Valentin Blanchard, Gordon A. Francis   +2 more
doaj   +1 more source

TREM-1 is a positive regulator of TNF-α and IL-8 production in U937 foam cells

Biomolecules & Biomedicine, 2012
The purpose of our study was to investigate the expression levels of TREM-1 (triggering receptor expressed on myeloid cells-1) in U937 foam cells and determine whether TREM-1 regulates the production of tumor necrosis factor-alpha and interleukin-8 in ...
Yu-Shi Wang, Xiang-Jun Li, Wai-Ou Zhao
doaj   +1 more source

Recombinant Klotho protein enhances cholesterol efflux of THP-1 macrophage-derived foam cells via suppressing Wnt/β-catenin signaling pathway

BMC Cardiovascular Disorders, 2020
Background Atherosclerosis (AS) is the basis of cardiovascular diseases, characterized by chronic inflammatory and lipid metabolism disorders. Although the anti-inflammatory effect of Klotho in AS has been clearly shown, its lipid-lowering effect is ...
Wei Liu, Xiujuan Chen, Min Wu, Lin Li, Jiani Liu, Jing Shi, Tian Hong   +6 more
doaj   +1 more source

Identification and validation of hub genes involved in foam cell formation and atherosclerosis development via bioinformatics [PDF]

PeerJ, 2023
Background Foam cells play crucial roles in all phases of atherosclerosis. However, until now, the specific mechanisms by which these foam cells contribute to atherosclerosis remain unclear.
Da Teng, Hongping Chen, Wenjuan Jia, Qingmiao Ren, Xiaoning Ding, Lihui Zhang, Lei Gong, Hua Wang, Lin Zhong, Jun Yang   +9 more
doaj   +2 more sources

Static Compressive Properties of Polypropylene Fiber Foam Concrete with Concave Hexagonal Unit Cell

Applied Sciences, 2022
For the purpose of studying the influence of fiber on the negative Poisson’s ratio effect of foam concrete, a concave hexagonal unit cell structure of polypropylene fiber foam concrete was proposed.
Zhiqiang Yin, Zhenguo Shao, Chao Qi, Haoyuan Wu, Jianen Wang, Lulu Gao   +5 more
doaj   +1 more source

Oxysterol efflux from macrophage foam cells: the essential role of acceptor phospholipid

Journal of Lipid Research, 1999
Oxidized forms of cholesterol (oxysterols) are present in atherosclerotic lesions and may play an active role in lesion development. For example, 7-ketocholesterol (7KC) inhibits cholesterol efflux from macrophage foam cells induced by apolipoprotein A-I
Ingrid C. Gelissen, Kerry-Ann Rye, Andrew J. Brown, Roger T. Dean, Wendy Jessup   +4 more
doaj   +1 more source

Nϵ-Carboxymethyl-Lysine Deteriorates Vascular Calcification in Diabetic Atherosclerosis Induced by Vascular Smooth Muscle Cell-Derived Foam Cells

Frontiers in Pharmacology, 2020
Nϵ-carboxymethyl-lysine (CML), an advanced glycation end product, is involved in vascular calcification (VC) in diabetic atherosclerosis. This study aimed to investigate the effects of CML on VC in diabetic atherosclerosis induced by vascular smooth ...
Sui-Ning Xu, Xin Zhou, Cun-Jun Zhu, Wei Qin, Jie Zhu, Ke-Lin Zhang, Hui-Jin Li, Lu Xing, Kun Lian, Cheng-Xiang Li, Zhen Sun, Zhong-Qun Wang, An-Ji Zhang, Hui-Ling Cao   +13 more
doaj   +1 more source

Cholesterol loading suppresses the atheroinflammatory gene polarization of human macrophages induced by colony stimulating factors

Scientific Reports, 2021
In atherosclerotic lesions, blood-derived monocytes differentiate into distinct macrophage subpopulations, and further into cholesterol-filled foam cells under a complex milieu of cytokines, which also contains macrophage-colony stimulating factor (M-CSF)
Jani Lappalainen, Nicolas Yeung, Su D. Nguyen, Matti Jauhiainen, Petri T. Kovanen, Miriam Lee-Rueckert   +5 more
doaj   +1 more source